Suchergebnisse

Cardiovascular diseases (CVDs) is a leading cause of death worldwide, and is characterized by a range of conditions that affect the heart and blood vessels. The extract of Vaccinium myrtillus L. fruit has been found to have cardioprotective effect. Human paraoxonases (PON1, PON2, PON3) genes play an important role in protecting against the development of CVDs by acting as antioxidants and anti-inflammatory agents.The present study aimed to investigate the chemical constituents and cardioprotective effects of V. myrtillus L. extract on TNF-α inflammation and oxidative stress in ECV-304 human endothelial cell line and the potential role of human paraoxonases in these effects. The results indicated that V. myrtillus L. extract has cardioprotective effects against inflammation and oxidative stress in ECV-304 cells, and these effects may be mediated through the upregulation of PON1, PON2, and PON3 genes. These findings suggest that V.myrtillus L. may have therapeutic potential for the prevention and treatment of CVDs.

The nuclear structure of neutron-rich nuclei close to the double-magic nucleus 78Ni has been investigated by measuring the lifetime of excited states. In this contribution, it will be presented the lifetime of the Jπ = 7=2 excited state at 981 keV of the 71Cu isotope, measured using the AGATA Demonstrator coupled to the PRISMA spectrometer and the Köln plunger setup. This is the first time this combined setup has been used for a lifetime measurement. ; This work has been partially supported by the grants FPA2008-06419, FPA2008-03774, AIC10-D-000605, AIC-D-2011-0764 and Consolider CSD2007-00042 from the Spanish Government and by INFN Italy. ; Peer Reviewed

WOS: 000350998600002 ; The level structure of the neutron-rich Cu-69, Cu-71, and Cu-73 isotopes has been investigated by means of multinucleon transfer reactions. The experiment was performed at Laboratori Nazionali di Legnaro using the AGATA Demonstrator array coupled to the PRISMA magnetic spectrometer. Lifetimes of excited states in Cu nuclei were measured with the recoil-distance Doppler-shift method. The resulting electromagnetic matrix elements for transitions from excited states in Cu-69,Cu-71,Cu-73 nuclei are used to assess the collective or single-particle character of these states. The results are compared with predictions of large-scale shell-model calculations, giving further insight into the evolution of the proton pf shell as neutrons fill the 1g(9/2) orbital. ; European Union Seventh Framework Program FP7 [262010]; ENSAR; MINECO, Spain [FPA2011-29854-C03, FPA2011-29854-C04, Consolider-Ingenio 2010 CSD2007-00042]; Generalitat Valenciana, Spain [PROMETEOII/2014/019] ; This work has been partially supported by the European Union Seventh Framework Program FP7/2007-2013 under Grant Agreement No. 262010, ENSAR and MINECO, Spain, under Grants No. FPA2011-29854-C03 and No. FPA2011-29854-C04, Generalitat Valenciana, Spain, under Grant No. PROMETEOII/2014/019, and MINECO, Spain, under Grant Consolider-Ingenio 2010 CSD2007-00042.