Synthesis of leucine-based cyclic dipeptides
In: Proceedings of the National Academy of Sciences of Belarus, Chemical Series, Band 56, Heft 3, S. 311-317
ISSN: 2524-2342
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In: Proceedings of the National Academy of Sciences of Belarus, Chemical Series, Band 56, Heft 3, S. 311-317
ISSN: 2524-2342
In: Proceedings of the National Academy of Sciences of Belarus, Chemical Series, Band 59, Heft 3, S. 211-224
ISSN: 2524-2342
Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.
In: Proceedings of the National Academy of Sciences of Belarus, Chemical Series, Band 55, Heft 4, S. 429-435
ISSN: 2524-2342
Tert-butyloxycarbonylprolylleucylglycinamide is obtained both by the interaction of tert-butyloxycarbonylprol ylleucylglycine ethyl ester with a methanolic ammonia solution and by the reaction of glycine amide with a mixed anhydride which was synthesized from tert-butyloxycarbonylprolylleucine and isobutylchloroformate. The removal of the tert-butyloxycarbonyl group by the action of formic acid or a dioxane solution of hydrogen chloride and treatment of the resulting salts with the corresponding base yielded a prolylleucylglycinamide, by the interaction of which with acetic, benzoic or 5-phenylisoxazole-3-carboxylic acids chlorides acyl derivatives of prolylleucylglycinamide are obtained.