Aktuelle molekulare Diagnostik beim malignen Melanom
In: Aktuelle Dermatologie: Organ der Arbeitsgemeinschaft Dermatologische Onkologie ; Organ der Deutschen Gesellschaft für Lichtforschung, Band 43, Heft 1/02, S. 46-59
ISSN: 1438-938X
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In: Aktuelle Dermatologie: Organ der Arbeitsgemeinschaft Dermatologische Onkologie ; Organ der Deutschen Gesellschaft für Lichtforschung, Band 43, Heft 1/02, S. 46-59
ISSN: 1438-938X
In: Natural hazards and earth system sciences: NHESS, Band 7, Heft 2, S. 327-342
ISSN: 1684-9981
Abstract. The preconvective environment on days with ordinary, widespread, and severe thunderstorms in Southwest Germany was investigated. Various thermodynamic and kinetic parameters calculated from radiosoundings at 12:00 UTC were verified against subsequent thunderstorm observations derived from SYNOP station data, radar data, and damage reports of a building insurance company. The skill of the convective parameters and indices to predict thunderstorms was evaluated by means of probability distribution functions, probabilities of thunderstorms according to an index threshold, and skill scores like the Heidke Skill Score (HSS) that are based on categorical verification. For the ordinary decision as to whether a thunderstorm day was expected or not, the best results were obtained with the original Lifted Index (80% prediction probability for LI≤−1.73; HSS=0.57 for LI≤1.76), the Showalter Index, and the modified K-Index. Considering days with isolated compared to widespread thunderstorms, the best performance is reached by the Deep Convective Index. For days with severe thunderstorms that caused damage due to hail, local storms or floods, the best prediction skill is found again for the Lifted Index and the Deep Convective Index, but also for the Potential Instability Index, the Delta-θe Index, and a version of the CAPE, where the lifting profile is determined by averaging over the lowest 100 hPa.
In: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, Band 8, Heft 37
ISSN: 1424-4020
In: Aktuelle Dermatologie: Organ der Arbeitsgemeinschaft Dermatologische Onkologie ; Organ der Deutschen Gesellschaft für Lichtforschung, Band 27, Heft 12, S. 409-413
ISSN: 1438-938X
In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 163, S. 104813
ISSN: 0149-1970
In: Aktuelle Dermatologie: Organ der Arbeitsgemeinschaft Dermatologische Onkologie ; Organ der Deutschen Gesellschaft für Lichtforschung, Band 46, Heft 6, S. 275-277
ISSN: 1438-938X
ZusammenfassungEs wird über den Fall einer 13-jährigen Patientin mit neu aufgetretenen, auf Druck schmerzhaften Hautveränderungen beidseits am Hals und im Gesicht berichtet. Auf Nachfrage traten die Effloreszenzen episodisch im Rahmen von Stresssituationen auf. Im Verlauf kam es zu einer Spontanheilung mit Narbenbildung und mehreren Rezidiven. Nach erfolgter Probebiopsie wurde ein Gardner-Diamond-Syndrom ausgeschlossen und der Verdacht auf selbstinduzierte Hautläsionen geäußert.
In: Natural hazards and earth system sciences: NHESS, Band 10, Heft 4, S. 907-922
ISSN: 1684-9981
Abstract. Frequency and intensity of gust wind speeds associated with severe mid-latitude winter storms are estimated by applying extreme value statistics to data sets from regional climate models (RCM). Maximum wind speeds related to probability are calculated with the classical peaks over threshold method, where a statistical distribution function is fitted to the reduced sample describing the tail of the distribution function. From different sensitivity studies it is found that the Generalized Pareto Distribution in combination with a Maximum-Likelihood estimator provide the most reliable and robust results. For a reference period from 1971 to 2000, the ability of the RCMs to realistically simulate extreme wind speeds is investigated. For this purpose, data from three RCM scenarios, including the REMO-UBA simulations at 10 km resolution and the so-called consortial runs performed with the CCLM at 18 km resolution (two runs), are evaluated with observations and a pre-existing storm hazard map for Germany. It is found that all RCMs tend to underestimate the magnitude of the gusts in a range between 10 and 30% for a 10-year return period. Averaged over the investigation area, the underestimation is higher for CCLM compared to REMO. The spatial distribution of the gusts, on the other hand, is well reproduced, in particular by REMO.
In: Aktuelle Dermatologie: Organ der Arbeitsgemeinschaft Dermatologische Onkologie ; Organ der Deutschen Gesellschaft für Lichtforschung, Band 30, Heft 8/09
ISSN: 1438-938X
Widespread flooding in June 2013 caused damage costs of €6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of €11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all stakeholders.
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Widespread flooding in June 2013 caused damage costs of €6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of €11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all ...
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At the end of October 2012, Hurricane Sandy moved from the Caribbean Sea into the Atlantic Ocean and entered the United States not far from New York. Along its track, Sandy caused more than 200 fatalities and severe losses in Jamaica, Bahamas, Haiti, Cuba, and the US. This paper demonstrates the capability and potential for near-real time analysis of catastrophes. It is shown that the impact of Sandy was driven by the superposition of different extremes (high wind speeds, storm surge, heavy precipitation) and by cascading effects. In particular the interaction between Sandy and an extra-tropical weather system created a huge storm that affected large areas in the US. It is examined how Sandy compares to historic hurricane events, both from a hydro-meteorological and impact perspective. The distribution of losses to different sectors of the economy is calculated with simple input-output models as well as government estimates. Direct economic losses are estimated about 4.2 billion US$ in the Caribbean and between 78 and 97 billion US$ for the US. Indirect economic losses from power outages is estimated in the order of 16.3 billion US$. Modelling sector-specific dependencies, quantifies total business interruption losses between 10.8 and 15.5 billion US$. Thus, seven years after the record impact of Hurricane Katrina in 2005, Hurricane Sandy is the second costliest hurricane in the history of the United States.
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At the end of October 2012, Hurricane Sandy moved from the Caribbean Sea into the Atlantic Ocean and entered the United States not far from New York. Along its track, Sandy caused more than 200 fatalities and severe losses in Jamaica, The Bahamas, Haiti, Cuba, and the US. This paper demonstrates the capability and potential for near-real-time analysis of catastrophes. It is shown that the impact of Sandy was driven by the superposition of different extremes (high wind speeds, storm surge, heavy precipitation) and by cascading effects. In particular the interaction between Sandy and an extra-tropical weather system created a huge storm that affected large areas in the US. It is examined how Sandy compares to historic hurricane events, both from a hydro-meteorological and impact perspective. The distribution of losses to different sectors of the economy is calculated with simple input-output models as well as government estimates. Direct economic losses are estimated about USD 4.2 billion in the Caribbean and between USD 78 and 97 billion in the US. Indirect economic losses from power outages is estimated in the order of USD 16.3 billion. Modelling sector-specific dependencies quantifies total business interruption losses between USD 10.8 and 15.5 billion. Thus, seven years after the record impact of Hurricane Katrina in 2005, Hurricane Sandy is the second costliest hurricane in the history of the United States.
BASE
In: Natural hazards and earth system sciences: NHESS, Band 13, Heft 10, S. 2579-2598
ISSN: 1684-9981
Abstract. At the end of October 2012, Hurricane Sandy moved from the Caribbean Sea into the Atlantic Ocean and entered the United States not far from New York. Along its track, Sandy caused more than 200 fatalities and severe losses in Jamaica, The Bahamas, Haiti, Cuba, and the US. This paper demonstrates the capability and potential for near-real-time analysis of catastrophes. It is shown that the impact of Sandy was driven by the superposition of different extremes (high wind speeds, storm surge, heavy precipitation) and by cascading effects. In particular the interaction between Sandy and an extra-tropical weather system created a huge storm that affected large areas in the US. It is examined how Sandy compares to historic hurricane events, both from a hydro-meteorological and impact perspective. The distribution of losses to different sectors of the economy is calculated with simple input-output models as well as government estimates. Direct economic losses are estimated about USD 4.2 billion in the Caribbean and between USD 78 and 97 billion in the US. Indirect economic losses from power outages is estimated in the order of USD 16.3 billion. Modelling sector-specific dependencies quantifies total business interruption losses between USD 10.8 and 15.5 billion. Thus, seven years after the record impact of Hurricane Katrina in 2005, Hurricane Sandy is the second costliest hurricane in the history of the United States.
At the end of October 2012, Hurricane Sandy moved from the Caribbean Sea into the Atlantic Ocean and entered the United States not far from New York. Along its track, Sandy caused more than 200 fatalities and severe losses in Jamaica, The Bahamas, Haiti, Cuba, and the US. This paper demonstrates the capability and potential for near-real-time analysis of catastrophes. It is shown that the impact of Sandy was driven by the superposition of different extremes (high wind speeds, storm surge, heavy precipitation) and by cascading effects. In particular the interaction between Sandy and an extra-tropical weather system created a huge storm that affected large areas in the US. It is examined how Sandy compares to historic hurricane events, both from a hydro-meteorological and impact perspective. The distribution of losses to different sectors of the economy is calculated with simple input-output models as well as government estimates. Direct economic losses are estimated about USD 4.2 billion in the Caribbean and between USD 78 and 97 billion in the US. Indirect economic losses from power outages is estimated in the order of USD 16.3 billion. Modelling sector-specific dependencies quantifies total business interruption losses between USD 10.8 and 15.5 billion. Thus, seven years after the record impact of Hurricane Katrina in 2005, Hurricane Sandy is the second costliest hurricane in the history of the United States.
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Context. Stage IV weak lensing experiments will offer more than an order of magnitude leap in precision. We must therefore ensure that our analyses remain accurate in this new era. Accordingly, previously ignored systematic effects must be addressed.Aims. In this work, we evaluate the impact of the reduced shear approximation and magnification bias on information obtained from the angular power spectrum. To first-order, the statistics of reduced shear, a combination of shear and convergence, are taken to be equal to those of shear. However, this approximation can induce a bias in the cosmological parameters that can no longer be neglected. A separate bias arises from the statistics of shear being altered by the preferential selection of galaxies and the dilution of their surface densities in high-magnification regions.Methods. The corrections for these systematic effects take similar forms, allowing them to be treated together. We calculated the impact of neglecting these effects on the cosmological parameters that would be determined from Euclid, using cosmic shear tomography. To do so, we employed the Fisher matrix formalism, and included the impact of the super-sample covariance. We also demonstrate how the reduced shear correction can be calculated using a lognormal field forward modelling approach.Results. These effects cause significant biases in Omega (m), sigma (8), n(s), Omega (DE), w(0), and w(a) of -0.53 sigma, 0.43 sigma, -0.34 sigma, 1.36 sigma, -0.68 sigma, and 1.21 sigma, respectively. We then show that these lensing biases interact with another systematic effect: the intrinsic alignment of galaxies. Accordingly, we have developed the formalism for an intrinsic alignment-enhanced lensing bias correction. Applying this to Euclid, we find that the additional terms introduced by this correction are sub-dominant. ; Royal Society of London NASA Postdoctoral Program Fellowship UK Science and Technologies Facilities Council National Aeronautics & Space Administration (NASA) European Space Agency Academy of Finland Italian Space Agency (ASI) Belgian Federal Science Policy Office Canadian Euclid Consortium Centre National D'etudes Spatiales Helmholtz Association German Aerospace Centre (DLR) Danish Space Research Institute Portuguese Foundation for Science and Technology Spanish Government Netherlandse Onderzoekschool Voor Astronomie Norwegian Space Agency Romanian Space Agency State Secretariat for Education, Research and Innovation (SERI) at the Swiss Space Office (SSO) United Kingdom Space Agency
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