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THE END OF THE COLD WAR AND THE UNIFICATION OF GERMANY HAVE TRANSFORMED THE UNIVERSE IN WHICH FRENCH FOREIGN POLICY OPERATES. THE GERMAN QUESTION BECAME AN IDENTITY CRISIS OF THE FRENCH POLITICAL CLASS, AND A FRENCH QUESTION. WHAT WAS FRANCE'S ROLE TO BE IN THE NEW EUROPE? THIS ARTICLE EXPLORES THE FRANCO-GERMAN RELATIONSHIP AND THE FRENCH PLAN FOR EUROPE. IN THE PAST, FRANCE MADE THE MISTAKE OF ASKING GERMANY TO CHOOSE BETWEEN FRANCE AND THE UNITED STATES. IT IS NOT IN THE U.S. INTEREST TO FORCE EUROPE TO CHOOSE BETWEEN A GENUINE EUROPEAN IDENTITY AND THE UNITED STATES, PROVIDED A MORE MATURE PARTNERSHIP BETWEEN THE OLD WORLD AND THE NEW BECOMES POSSIBLE.

Lord Acton's detachment, keen historical sense and vast knowledge reveal an insight applicable to recent Latin-American events. As Acton warned, "History must be our deliverer not only from the undue influence of other times, but from the undue influence of our own".John Emerich Edward Dalberg Acton was born in Naples in 1834. His paternal grandfather had made his career in the service of the King of Naples whose Prime Minister he was during the period of the French Revolution and Napoleon. His maternal grandfather was a noble of the Holy Roman Empire who served Napoleon and sat as a peer of France and a colleague of Talleyrand at the Congress of Vienna. His maternal great-uncle had been Archbishop Elector of Mainz, and his wife's family, the Arco Valleys, were active in French politics in the first half of the nineteenth century. Acton's step-father was Lord Granville, several times British Foreign Secretary.

OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship models, and toxicological information through an integrating platform that adheres to regulatory requirements and OECD validation principles. Initial research defined the essential components of the Framework including the approach to data access, schema and management, use of controlled vocabularies and ontologies, architecture, web service and communications protocols, and selection and integration of algorithms for predictive modelling. OpenTox provides end-user oriented tools to non-computational specialists, risk assessors, and toxicological experts in addition to Application Programming Interfaces (APIs) for developers of new applications. OpenTox actively supports public standards for data representation, interfaces, vocabularies and ontologies, Open Source approaches to core platform components, and community-based collaboration approaches, so as to progress system interoperability goals.The OpenTox Framework includes APIs and services for compounds, datasets, features, algorithms, models, ontologies, tasks, validation, and reporting which may be combined into multiple applications satisfying a variety of different user needs. OpenTox applications are based on a set of distributed, interoperable OpenTox API-compliant REST web services. The OpenTox approach to ontology allows for efficient mapping of complementary data coming from different datasets into a unifying structure having a shared terminology and representation.Two initial OpenTox applications are presented as an illustration of the potential impact of OpenTox for high-quality and consistent structure-activity relationship modelling of REACH-relevant endpoints: ToxPredict which predicts and reports on toxicities for endpoints for an input chemical structure, and ToxCreate which builds and validates a predictive toxicity model based on an input toxicology dataset. Because of the extensible nature of the standardised Framework design, barriers of interoperability between applications and content are removed, as the user may combine data, models and validation from multiple sources in a dependable and time-effective way.

OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship models, and toxicological information through an integrating platform that adheres to regulatory requirements and OECD validation principles. Initial research defined the essential components of the Framework including the approach to data access, schema and management, use of controlled vocabularies and ontologies, architecture, web service and communications protocols, and selection and integration of algorithms for predictive modelling. OpenTox provides end-user oriented tools to non-computational specialists, risk assessors, and toxicological experts in addition to Application Programming Interfaces (APIs) for developers of new applications. OpenTox actively supports public standards for data representation, interfaces, vocabularies and ontologies, Open Source approaches to core platform components, and community-based collaboration approaches, so as to progress system interoperability goals. The OpenTox Framework includes APIs and services for compounds, datasets, features, algorithms, models, ontologies, tasks, validation, and reporting which may be combined into multiple applications satisfying a variety of different user needs. OpenTox applications are based on a set of distributed, interoperable OpenTox API-compliant REST web services. The OpenTox approach to ontology allows for efficient mapping of complementary data coming from different datasets into a unifying structure having a shared terminology and representation. Two initial OpenTox applications are presented as an illustration of the potential impact of OpenTox for high-quality and consistent structure-activity relationship modelling of REACH-relevant endpoints: ToxPredict which predicts and reports on toxicities for endpoints for an input chemical structure, and ToxCreate which builds and validates a predictive toxicity model based on an input toxicology dataset. Because of the extensible nature of the standardised Framework design, barriers of interoperability between applications and content are removed, as the user may combine data, models and validation from multiple sources in a dependable and time-effective way.