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Introduction: The aim of this prospective cohort study was to compute the clinical survival and complication rates of a miniplate with a tube device (C-tube) used for orthodontic treatment. Methods: From August 2003 to May 2012, 217 patients were recruited. They received 341 C-tube miniplates. Some C-tube miniplates were removed because orthodontic treatment ended. Others remained beyond the study period and were recorded as censored data. Survival was classified as a C-tube miniplate that functioned in the mouth regardless of any complications. Success was defined as survival without complications. From the data, the effects of these clinical variables on the survival of the C-tube miniplates were evaluated: sex, age, jaw, placement sites, oral hygiene, tube clearance, inflammation, miniplate shape, number of screws, and length of the fixation screws. Survival analyses using the Kaplan-Meier method and the Cox proportional hazard model were applied. Results: Of the 341 miniplates, 14 failed, and 32 had complications. Two-year survival and success rates were 0.91 and 0.80, respectively. In terms of the simple ratio statistic, this was equivalent to a success rate of 96%. The status of oral hygiene maintenance and the operators' experience had significant associations with the complication rates #P <0.001#. Conclusions: The C-tube miniplate has an advantage in versatility in terms of force application. When placing a miniplate, the most important factor is maintaining good tissue health by means of good oral hygiene. Even with good hygiene, the doctor's experience in performing the flap surgery was the second most important factor for success. ; This work is supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the MSIP, Korean government (grants 2012-0007545 and 2012-0047622). ; OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000030821/7 ; SEQ:7 ; PERF_CD:SNU2013-01 ; EVAL_ITEM_CD:102 ; USER_ID:0000030821 ; ADJUST_YN:Y ; EMP_ID:A076080 ; DEPT_CD:861 ; CITE_RATE:1.458 ; FILENAME:첨부된 내역이 없습니다. ; DEPT_NM:치의학과 ; EMAIL:nonext@snu.ac.kr ; SCOPUS_YN:Y ; CONFIRM:Y

Biological systems often generate unique and useful structures, which can have industrial relevance either as direct components or as an inspiration for biomimetic materials. For fabrication of nanoscale silica structures, we explored the use of the silaffin R5 peptide from Cylindrotheca fusiformis expressed on the surface of the fd bacteriophage. By utilizing the biomineralizing peptide component displayed on the bacteriophage surface, we found that low concentrations (0.09 mg/mL of the R5 bacteriophage, below the concentration range used in other studies) could be used to create silica nanofibers. An additional benefit of this approach is the ability of our R5-displaying phage to form silica materials without the need for supplementary components, such as aminopropyl triethoxysilane, that are typically used in such processes. Because this method for silica formation can occur under mild conditions when implementing our R5 displaying phage system, we may provide a relatively simple, economical, and environmentally friendly process for creating silica nanomaterials. ; This work was supported by the Korea CCS R&D Center (Korea CCS2020 Project) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) in 2017 (KCRC-2014M1A8A1049296) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1A6A1A03013422). H. Kim was financially supported by Korea Environmental Industry & Technology Institute (Project No: 2015001790002).