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[EN] In this work, we propose a new Bayesian model for unsupervised image segmentation based on a combination of the spatially varying finite mixture models (SVFMMs) and the non-local means (NLM) framework. The probabilistic NLM weighting function is successfully integrated into a varying Gauss¿Markov random field, yielding a prior density that adaptively imposes a local regularization to simultaneously preserve edges and enforce smooth constraints in homogeneous regions of the image. Two versions of our model are proposed: a pixel-based model and a patch-based model, depending on the design of the probabilistic NLM weighting function. Contrary to previous methods proposed in the literature, our approximation does not introduce new parameters to be estimated into the model, because the NLM weighting function is completely known once the neighborhood of a pixel is fixed. The proposed model can be estimated in closed-form solution via a maximum a posteriori (MAP) estimation in an expectation¿maximization scheme. We have compared our model with previously proposed SVFMMs using two public datasets: the Berkeley Segmentation dataset and the BRATS 2013 dataset. The proposed model performs favorably to previous approaches in the literature, achieving better results in terms of Rand Index and Dice metrics in our experiments. ; This study is partially supported by Secretaria de Estado de Investigacion, Desarrollo e Innovacion (DPI2016-80054-R, TIN2013-43457-R) and Agencia Valenciana de la Innovacion (INNVAL10/18/048). E.F.G was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement (No. 844646) and also acknowledges the support of NVIDIA GPU Grant Program. ; Juan -Albarracín, J.; Fuster García, E.; Juan, A.; Garcia-Gomez, JM. (2021). Non-local spatially varying finite mixture models for image segmentation. Statistics and Computing. 31(1):1-10. https://doi.org/10.1007/s11222-020-09988-w ; S ; 1 ; 10 ; 31 ; 1

[EN] Objectives To assess the combined role of tumor vascularity, estimated from perfusion MRI, andMGMTmethylation status on overall survival (OS) in patients with glioblastoma. Methods A multicentric international dataset including 96 patients from NCT03439332 clinical study were used to study the prognostic relationships betweenMGMTand perfusion markers. Relative cerebral blood volume (rCBV) in the most vascularized tumor regions was automatically obtained from preoperative MRIs using ONCOhabitats online analysis service. Cox survival regression models and stratification strategies were conducted to define a subpopulation that is particularly favored byMGMTmethylation in terms of OS. Results rCBV distributions did not differ significantly (p > 0.05) in the methylated and the non-methylated subpopulations. In patients with moderately vascularized tumors (rCBV 10.73),MGMTmethylation was a positive predictive factor for OS (HR = 2.73,p = 0.003, AUC = 0.70). In patients with highly vascularized tumors (rCBV > 10.73), however, there was no significant effect ofMGMTmethylation (HR = 1.72,p = 0.10, AUC = 0.56). Conclusions Our results indicate the existence of complementary prognostic information provided byMGMTmethylation and rCBV. Perfusion markers could identify a subpopulation of patients who will benefit the most fromMGMTmethylation. Not considering this information may lead to bias in the interpretation of clinical studies. ; Open Access funding provided by University of Oslo (incl Oslo University Hospital). This study has received funding from MTS4up project (National Plan for Scientific and Technical Research and Innovation 2013-2016, No. DPI2016-80054-R) (JMGG); H2020-SC12016-CNECT Project (No. 727560) (JMGG), H2020-SC1-BHC-20182020 (No. 825750) (JMGG), the European Research Council (ERC) under the European Union's Horizon 2020 (Grant Agreement No. 758657), the South-Eastern Norway Regional Health Authority Grants 2017073 and 2013069, the Research Council of Norway Grants 261984 (KEE). M.A.T was ...