China's web diplomacy: current state and the way forward
In: China international studies, Band 18, Heft 5, S. 45-56
ISSN: 1673-3258
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In: China international studies, Band 18, Heft 5, S. 45-56
ISSN: 1673-3258
World Affairs Online
In: Environmental science and pollution research: ESPR, Band 29, Heft 58, S. 86899-86912
ISSN: 1614-7499
In: Materials and design, Band 88, S. 743-750
ISSN: 1873-4197
In: Environmental science and pollution research: ESPR, Band 31, Heft 2, S. 2671-2686
ISSN: 1614-7499
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 191, S. 106502
In: WM-23-2821
SSRN
In: Defence Technology, Band 18, Heft 4, S. 709-721
ISSN: 2214-9147
In: CHEM98189
SSRN
The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosan-graphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University (Army Medical University) (approval No. AMUWEC20191327) on August 30, 2019.
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