The brain, the mind, and societal and cultural learning: the emergence of a new paradigm of futures research
In: Futures, Band 34, Heft 6, S. 509-521
3 Ergebnisse
Sortierung:
In: Futures, Band 34, Heft 6, S. 509-521
In: Futures: the journal of policy, planning and futures studies, Band 34, Heft 6, S. 509-522
ISSN: 0016-3287
This is the final version of the article. Available from Springer Nature via the DOI in this record. ; Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection. ; N.L. is supported by the Lister Institute of Preventive Medicine. J.C. and A.E. were funded by the Welsh Government and Higher Education Funding Council for Wales through the Sêr Cymru National Research Network for Low Carbon, Energy and Environment AquaWales Project. C.R.T. and M.J.D. were funded by the Leverhulme Trust. Work in the Fisher laboratory is supported by the UK Natural Environmental Research Council (NERC NE/K014455/1) and the Leverhulme Trust. Work in the Mostowy laboratory is supported by a Wellcome Trust Research Career Development Fellowship (WT097411MA) and the Lister Institute of Preventive Medicine.
BASE