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Acknowledgements This work is supported by the MRC Doctoral Training Programme in Precision Medicine (JB); the Wellcome Trust (patient recruitment, scanning, and primary study - Reference No. WT088134/Z/09/A); the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK MRC, Alzheimer's Society, and Alzheimer's Research UK; the Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease (16 CVD 05); The Row Fogo Charitable Trust Centre for Research into ageing and the Brain (MVH) (BRO-D.FID3668413); a British Heart Foundation Chair award (RMT) (CH/12/4/29762); and NHS Lothian Research and Development Office (MJT); European Union Horizon 2020, PHC-03-15, project No666881. We thank the participants, their families, radiographers at Edinburgh Imaging, and the Stroke Research Network at the University of Edinburgh. ; Peer reviewed ; Publisher PDF

Funding Information: The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Wellcome Trust [grant number WT088134/Z/09/A ; SDJM, FC]; Row Fogo Charitable Trust (MCVH, FC, AKH, PAA); Scottish Funding Council Scottish Imaging Network A Platform for Scientific Excellence collaboration (JMW); NHS Lothian R + D Department (MJT); the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK MRC, Alzheimer's Research UK and the Alzheimer's Society (MS, FC, ES, JMW); the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease [reference number 16 CVD 05] (MS); and European Union Horizon 2020 [project number 666881, SVDs@Target] (MS, FC). We acknowledge the participants, their relatives, and carers for their participation in this study, and the staff of NHS Lothian Stroke Services and Brain Research Imaging Centre Edinburgh for their assistance in recruiting and assessing the patients. ; Peer reviewed ; Publisher PDF

The project was funded by the Wellcome Trust (WT088134/Z/09/A; S.D.J.M, project costs), the Row Fogo Charitable Trust (M.d.C.V.H., A.K.H.), AgeUK (S.M.-M.), the European Union Horizon 2020 project 666881, SVDs@Target (F.M.C.). The Brain Imaging Centre is supported by the Scottish Funding Council SINAPSE Initiative (www.sinapse.ac.uk); funding from the Fondation Leducq (16-CVD-05) is gratefully acknowledged. J.S. was supported by Maastricht University Medical Centre Academic Fund. The study was conducted independently of the funders. The Article Processing Charge was funded by the Wellcome Trust via the University of Edinburgh. ; Peer reviewed ; Publisher PDF