Suchergebnisse

El progresivo envejecimiento de la población incrementa la demanda de políticas y programas de envejecimiento saludable. Aunque existen estudios que contemplan el impacto de esos programas sobre la calidad de vida de los mayores, son escasas las investigaciones que se ocupan de medir la satisfacción con los mismos. Por ello, nuestro objetivo es crear un cuestionario que permita analizar las características y el grado de satisfacción de estos usuarios. Para su diseño, se consideraron las características de las personas mayores, se contó con la asesoría de expertos, y con una muestra piloto inicial para testear el cuestionario planteado. La muestra final quedó conformada en 1641 personas. Los resultados describen a una mujer entre 66 y 75 años, casada, con estudios básicos y que vive acompañada. Además, muestran elevados niveles de satisfacción general para los aspectos relacionados con los docentes y los cursos y algo más ajustados en lo referido a los Centros. Los usuarios valoran especialmente el contexto social y psicológico (ambiente y compañerismo, entre otros) que trascienden a los conocimientos.

We overviewed the correlation between the structure, magnetic and transport properties of magnetic microwires prepared by the Taylor-Ulitovsky method involving rapid quenching from the melt and drawing of the composite (metallic core, glass coated) wire. We showed that this method can be useful for the preparation of different families of magnetic microwires: soft magnetic microwires displaying Giant magnetoimpedance (GMI) effect, semi-hard magnetic microwires, microwires with granular structure exhibiting Giant Magnetoresistance (GMR) effect and Heusler-type microwires. Magnetic and transport properties of magnetic microwires depend on the chemical composition of metallic nucleus and on the structural features (grain size, precipitating phases) of prepared microwires. In all families of crystalline microwires, their structure, magnetic and transport properties are affected by internal stresses induced by the glass coating, depending on the quenching rate. Therefore, properties of glass-coated microwires are considerably different from conventional bulk crystalline alloys ; This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) under Projects MAT2013-47231-C2-1-P and MAT2013-47231-C2-2-P. The authors thank for technical and human support provided by SGIker (Magnetic Measurements Gipuzkoa) of UPV/EHU. VZ and AZ wish to acknowledge the support under Program of Mobility of the Researchers of the Basque Government (grants MV-2016-1-0025 and MV-2016-1-0018 respectively)

[Background]: In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic approach focuses on sequencing a few classic high-risk genes, a method that frequently renders uninformative genetic results. This study aims to examine the improved yield offered by an On-Demand panel. ; [Methods]: We designed an On-Demand panel for the analysis of 35-genes associated with inherited cancer susceptibility in a total of 128 cases of Hereditary Breast and Ovarian Cancer (HBOC) and Hereditary Nonpolyposis Colorectal Cancer (HNPCC). ; [Results]: Eighteen deleterious mutations were detected, in both routinely (BRCA2, MLH1, MSH2, PMS2) and non-routinely (ATM, BLM, BRIP1, CHEK2, MUTYH) tested genes. The screening extended to 35 genes rendered by patients carrying several- up to 6-Variants of Unknown Significance (VUS). Moreover, we confirmed the splicing disruption at RNA level for a not previously reported BRIP1 splicing mutation. Using an On-Demand panel, we identified 18 pathogenic mutation carriers, seven of which would have gone unnoticed with traditional analysis. ; [Conclusions]: Our results reinforce the utility of NGS gene panels in the diagnostic routine to increase the performance of genetic testing, especially in individuals from families with overlapping cancer phenotypes. ; This work has been supported by the Regional Government of Castile & Leon to the University of Valladolid, Valladolid (Spain). Regional Health Management of Castile & Leon: GRS1547/A/17 and GRS175/A/18. Carolina Velázquez was supported by a predoctoral fellowship from the Regional Government of Castile & Leon (ORDEN EDU/1083/2013). ; Peer reviewed