Suchergebnisse

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Research on drug courts over the past decades has focused primarily on individual predictors of success and/or has examined the effectiveness of various judicial as well as therapeutic intervention strategies. To broaden our understanding of recovery as it occurs within the context of social networks, the following paper discusses the application of a new network-based framework of recovery capital. Participants in a small rural southeastern Adult Drug Court filled out a series of questionnaires and participated in a number of semi-structured interviews that assessed the availability of network-based recovery capital. The findings of this exploratory study suggest that participants possess restrictive resource portfolios and tend to over-rely on therapeutic (artificial) networks for support. Select implications for future research and treatment interventions are discussed.

Abstract

Background
Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early mortality, we hypothesized that patients with SCD are experiencing accelerated biological aging compared to individuals without SCD.


Methods
We utilized the DunedinPACE measure to compare the epigenetic pace of aging in 131 Black Americans with SCD to 1391 Black American veterans without SCD.


Results
SCD patients displayed a significantly accelerated pace of aging (DunedinPACE mean difference of 0.057 points) compared to the veterans without SCD, whereby SCD patients were aging approximately 0.7 months more per year than those without SCD (p=4.49x10-8). This was true, even though the SCD patients were significantly younger according to chronological age than the individuals without SCD, making the epigenetic aging discrepancy even more apparent. This association became stronger when we removed individuals with PTSD from the non-SCD group (p=2.18x10-9), and stronger still when we restricted the SCD patients to those with hemoglobin SS and Sβ0 thalassemia genotypes (p=1.61x10-10).


Conclusions
These data support our hypothesis that individuals with SCD experience accelerated biological aging as measured by global epigenetic variation. The assessment of epigenetic measures of biological aging may prove useful to identify which SCD patients would most benefit from clinical interventions to reduce mortality.