Suchergebnisse

1 Historical background and introduction -- 2 The administration of the Act -- 3 Medicinal products and other articles -- 4 The licensing system -- 5 Licences and certificates relating to products -- 6 Licences for activities -- 7 Controls over the sale and distribution of medicines -- 8 Wholesale sales -- 9 Retail sale of medicines for human use -- 10 Dispensing medicines -- 11 Sales, supplies and administration by exempted users -- 12 Herbal remedies -- 13 Homoeopathy and similar systems of medicine -- 14 Medicinal products for administration to animals -- 15 Medicated animal feeding stuffs -- 16 The packaging and labelling of medicines -- 17 The quality of medicinal products reaching the consumer -- 18 Promotion of sales of medicinal products -- 19 Advertisements and representations directed to practitioners -- 20 Advertisements directed to the public -- 21 Pharmacies -- Appendix 1: Definitions of words and phrases used in the Act and subordinate legislation -- Appendix 2: Recommended warning and advisory labels for dispensed medicines -- Appendix 3: Code of ethics of the Pharmaceutical Society of Great Britain -- Appendix 3B: Guide to good dispensing practice -- Appendix 3C: Guide to the self-assessment of professional practice activites -- Appendix 4: NHS limited list.

BACKGROUND: Individuals with severe mental health problems are at risk of social exclusion, which may complicate their recovery. Mental health and social care staff have, until now, had no valid or reliable way of assessing their clients' social inclusion. The Social Inclusion Questionnaire User Experience (SInQUE) was developed to address this. It assesses five domains: social integration; productivity; consumption; access to services; and political engagement, in the year prior to first psychiatric admission (T1) and the year prior to interview (T2) from which a total score at each time point can be calculated. AIMS: To establish the validity, reliability, and acceptability of the SInQUE in individuals with a broad range of psychiatric diagnoses receiving care from community mental health services and its utility for mental health staff. METHOD: Participants were 192 mental health service users with psychosis, personality disorder, or common mental disorder (e.g., depression, anxiety) who completed the SInQUE alongside other validated outcome measures. Test-retest reliability was assessed in a sub-sample of 30 participants and inter-rater reliability was assessed in 11 participants. SInQUE ratings of 28 participants were compared with those of a sibling with no experience of mental illness to account for shared socio-cultural factors. Acceptability and utility of the tool were assessed using completion rates and focus groups with staff. RESULTS: The SInQUE demonstrated acceptable convergent validity. The total score and the Social Integration domain score were strongly correlated with quality of life, both in the full sample and in the three diagnostic groups. Discriminant validity and test-retest reliability were established across all domains, although the test-retest reliability on scores for the Service Access and Political Engagement domains prior to first admission to hospital (T1) was lower than other domains. Inter-rater reliability was excellent for all domains at T1 and T2. CONCLUSIONS: The component ...

The world's most biodiverse river basins—the Amazon, Congo, and Mekong—are experiencing an unprecedented boom in construction of hydropower dams. These projects address important energy needs, but advocates often overestimate economic benefits and underestimate far-reaching effects on biodiversity and critically important fisheries. Powerful new analytical tools and high-resolution environmental data can clarify trade-offs between engineering and environmental goals and can enable governments and funding institutions to compare alternative sites for dam building. Current site-specific assessment protocols largely ignore cumulative impacts on hydrology and ecosystem services as ever more dams are constructed within a watershed (1). To achieve true sustainability, assessments of new projects must go beyond local impacts by accounting for synergies with existing dams, as well as land cover changes and likely climatic shifts (2, 3). We call for more sophisticated and holistic hydropower planning, including validation of technologies intended to mitigate environmental impacts. Should anything less be required when tampering with the world's great river ecosystems?