Suchergebnisse

According to theory, road pricing may reduce welfare when labour supply is negatively distorted by an income tax. This effect particularly occurs when commuting costs reduce labour supply. We examine the hypothesis that commuting costs reduce labour supply in the short-run. In particular, we estimate the effect of commuting time on labour supply in the UK. We account for endogeneity of commuting time by employing exogenous changes in commuting time resulting from firm relocations and changes in infrastructure. Our results cast doubt on the idea that increases in commuting cost reduce labour supply, at least in the short-run. More precisely, we find that females' labour supply reacts positively to or is unaffected by increases in commuting time, whereas males' labour supply is unaffected.

Open Access Article; Published online: 29 Oct 2020 ; Global diets have transitioned in recent decades with animal and processed products increasing. Promoting a reversal in these trends towards plant-based diets could reduce the environmental impacts of food systems and reduce the prevalence of non-communicable diseases and malnutrition. In Spain, a reference point for the Mediterranean diet (predominantly plant-source based), plant-based alternatives to traditional animal-based products are receiving increased attention. However, limited focus has been given to the opinions of stakeholder groups on the potential of these novel products. We evaluate the opinions of stakeholders within the Spanish agri-food sector, using multicriteria and SWOT analyses, on traditional and novel food products. Stakeholders involved in the supply chain of food products (producers, processors, and distributors) were critical of novel plant-based foods, highlighting problems with their taste, processing technology, and high prices. These results contrast with the perspectives of policymakers, researchers, environmental NGOs, and consumers who see novel products more positively - healthier, more sustainable, and highly profitable. These results illustrate the more traditional mindset seen in Spanish production systems, contrasting with the rapidly shifting tastes and demands of consumers and the potential legislative orientation of policymakers. This study calls for improved understanding and collaboration between stakeholders to better manage complex choices that affect the future of food systems during their needed transformation.

Open Access Journal; Published online: 04 Mar 2020 ; Global and European diets have shifted towards greater consumption of animal proteins. Recent studies urge reversals of these trends and call for a rapid transition towards adoption of more plant-based diets. This paper explored mechanisms to increase the production and consumption of plant-proteins in Europe by 2030, using participatory backcasting. We identified pathways to the future (strategies), as well as interim milestones, barriers, opportunities and actions, with key European stakeholders in the agri-food chain. Results show that four strategies could be implemented to achieve the desired future: increased research and development, enriched consumer education and awareness, improved and connected supply and value chains and public policy supports. Actions needed to reach milestones were required immediately, reinforcing the need for urgent actions to tackle the protein challenge. This study concretely detailed how idealized dietary futures can be achieved in a real-world context. It can support EU protein transition by informing policy makers and the broader public on potential ways to move towards a more sustainable plant-based future. The outputs of this analysis have the potential to be combined with dietary scenarios to develop more temporally explicit models of future dietary changes and how to reach them.

[EN] Genomes contain rare guanine-rich sequences capable of assembling into four-stranded helical structures, termed G-quadruplexes, with potential roles in gene regulation and chromosome stability. Their mechanical unfolding has only been reported to date by all-atom simulations, which cannot dissect the major physical interactions responsible for their cohesion. Here, we propose a mesoscopic model to describe both the mechanical and thermal stability of DNA G-quadruplexes, where each nucleotide of the structure, as well as each central cation located at the inner channel, is mapped onto a single bead. In this framework we are able to simulate loading rates similar to the experimental ones, which are not reachable in simulations with atomistic resolution. In this regard, we present single-molecule force-induced unfolding experiments by a high-resolution optical tweezers on a DNA telomeric sequence capable of adopting a G-quadruplex conformation. Fitting the parameters of the model to the experiments we find a correct prediction of the rupture-force kinetics and a good agreement with previous near equilibrium measurements. Since G-quadruplex unfolding dynamics is halfway in complexity between secondary nucleic acids and tertiary protein structures, our model entails a nanoscale paradigm for non-equilibrium processes in the cell. ; Work supported by the Spanish Ministry of Economy and Competitiveness (MINECO), grant No. FIS2014-55867, co-financed by FEDER funds. We also thank the support of the Aragon Government and Fondo Social Europeo to FENOL group. Work in J.R.A.-G. laboratory was supported by a grant from MINECO, No. MAT2015-71806-R). ; Bergues-Pupo, A.; Gutiérrez, I.; Arias-Gonzalez, JR.; Falo, F.; Fiasconaro, A. (2017). Mesoscopic model for DNA G-quadruplex unfolding. Scientific Reports. 7:1-13. https://doi.org/10.1038/s41598-017-10849-2 ; S ; 1 ; 13 ; 7 ; Arias-Gonzalez, J. R. Single-molecule portrait of DNA and RNA double helices. Integr. Biol. 6, 904 (2014). ; Burge, S., Parkinson, G. N., Hazel, P., ...

Open Access Journal ; The Amazon basin is the world's largest rainforest and the most biologically diverse place on Earth. Despite the critical importance of this region, Amazon forests continue inexorably to be degraded and deforested for various reasons, mainly a consequence of agricultural expansion. The development of novel policy strategies that provide balanced solutions, associating economic growth and environmental protection, is still challenging, largely because the perspective of those most affected- local stakeholders- is often ignored. Participatory Fuzzy Cognitive Mapping (FCM) was implemented to examinestakeholder perceptions towards the sustainable development of two agricultural-forest frontier areas in the Bolivian and Brazilian Amazon. A series of development scenarios and a climate change scenario were explored and applied to stakeholder derived FCM. Stakeholders in both regions perceived landscapes of socio-economic impoverishment and environmental degradation driven by governmental and institutional deficiencies. Under such abject conditions, governance and well-integrated social and technological strategies offered socio-economic development, environmental conservation, and resilience to climatic changes. The results suggest the benefits of a new type of thinking for development strategies in the Amazon basin, and that continued application of traditional development policies reduce the resilience of the Amazon to climate change, whilst limiting socio-economic development and environmental conservation. ; Peer Review