Suchergebnisse

Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2. We have compared the susceptibility of these three types of synaptic plasticity to depotentiation, induced by low frequency stimulation (LFS; 2 Hz for 10 min) at the Schaffer collateral-commissural pathway in area CA1 of adult rat hippocampal slices. In interleaved experiments, STP and LTP were induced by three episodes of either compressed or spaced TBS (cTBS or sTBS). LFS had a more pronounced effect on the LTP induced by the cTBS. One traditional interpretation of these results is a difference in the time-dependent immunity against depotentiation. We suggest an alternative explanation: LFS rapidly reverses STP to reveal a slowly developing LTP. The cTBS protocol induces LTP1 that is moderately sensitive to depotentiation. The sTBS induces an additional component of LTP (LTP2) that is resistant to depotentiation. ; This work was supported by the Brain Canada Foundation through the Canada Brain Research Fund, with the financial support of Health Canada. Additional support was provided by the MRC, ERC, Canadian Institute for Health Research (CIHR) Foundation grant (G.L.C), the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, Canada Research Chair, and CIHR operating grants (CIHR66975 and 84256) (M.Z.) and the National Honor Scientist Program of the National Research Foundation funded by the Korea government (2012R1A3A1050385) (B-K.K).