Suchergebnisse

La pretensión de este articulo de investigación es el análisis a través de un ejemplo singularizado, el del antiguo Asilo Pola localizado en la ciudad asturiana de Gijón, de la problemática que rodeaba a la beneficencia en España en la época del cambio de siglo. Observaremos como entre los objetivos claves de este tipo de establecimientos estaba la idea de paliar e Intentar poner fin a la mendicidad Infantil, considerada ésta como una verdadera enfermedad social que encontraba en la Ineducación una de las causas de su existencia. Desde una perspectiva sociológica abordaremos las bases en las que se fundamentaban las iniciativas encaminadas a la protección a la infancia, resaltando en este sentido la iniciativa de la Asociación Gijonesa de Caridad, pero sin perder como marco referencial las medidas de tipo legislativo aplicadas en todo el ámbito español. Junto a ello, incluimos un estudio histórico-artístico del asilo gijonés y de la vida cotidiana desarrollada en torno al mismo.This article tries to anallze, through a singular example —the old Asilo Pola sltuated in the asturian clty of Gijón— all the questions around the beneficence in Spain at the end of 19 th. century and the begining of the 20 th. The end of chlldren baggary was one of its objectlves. This work'll anallze the bases of this kind of initiatives too; in Asturias, but also in Spain. Besides, we include a hlstoric-artistic study about the Asilo Pola and the daily life in this asylum.

AbstractUterine leiomyosarcoma (LMS) contributes to a significant proportion of uterine cancer deaths. It is a rare and high-risk gynecological cancer. LMS is challenging to the treatment due to the resistance of several therapies. The activation of the Hedgehog (HH) pathway has been reported in several types of female cancers. Uterine LMS presents an upregulation of the crucial HH signaling pathway members such as SMO and GLI1. Although targeting the HH pathway exhibited a potent inhibitory effect on the phenotype of uterine LMS in vitro, the effect of the HH inhibitors on LMS growth in vivo has not been identified. The present study aimed to assess the effect of Hedgehog pathway inhibitors (SMO-LDE225 and GLI-Gant61) as a therapeutic option in the xenograft model of uterine LMS. The results demonstrated that LDE225 treatment did not show any inhibitory effect on LMS tumor growth; however, treatment with GLI inhibitor (Gant61) induced a remarkable tumor regression with a significant decrease in Ki67 expression, compared to control (p < 0.01). Moreover, administration of Gant61 decreased the expression of GLI1, GLI target genes BMP4 and c-MYC (p < 0.05), indicating that the HH pathway is implicated in the LMS experimental model. In conclusion, our studies demonstrate for the first time that GLI inhibitor (Gant61), but not SMO inhibitor (LDE225), shows a potent inhibitory effect on LMS tumor growth and concomitantly suppresses the expression of GLI1- and GLI-targeted genes using the xenograft model of uterine LMS.