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Abstract. Impact database development and application for risk analysis and management promote the usage of self-learning computer systems with elements of artificial intelligence. Such system learning could be successful when the databases store the complete information about each
event, parameters of the simulation models, the range of its application, and residual errors. Each new description included in the database could
increase the reliability of the results obtained with application of
simulation models. The calibration of mathematical models is the first step
to self-learning of automated systems. The article describes the events'
database structure and examples of calibrated computer models as applied to the impact of expected emergencies and risk indicator assessment. Examples of database statistics usage in order to rank the subjects of the Russian Federation by the frequency of emergencies of different character as well as risk indicators are given.

A fluorescent molecular rotor (FMR) based on boron dipyrromethene core was obtained. Fluorescence emission properties of the compound strongly depend on the medium viscosity. The emission intensity increases 27 times after viscosity changing from ethanol to glycerol medium. At the same time, the compound appeared almost insensitive to solvatochromic effects. Obtained FMR also can affinely bind with the bovine serum albumin protein active sites followed by noticeable emission intensity growth. Possible ligand binding cites and main amino acid surrounding were described with molecular docking simulations and are in an agreement with experimental data. The results can be used for further design and synthesis of novel fluorescent viscosity and protein-ligand interactions censors suitable for implementation in biosystems in vitro and in vivo.

A 3-acetyl analogue of 5-hydroxyindole was synthesised and evaluated for its effects on rat C6 glioma cell functions. It was found that 3-acetyl-5-hydroxy-2-methylindole at 10 μmol/L led to a sharp reduction of mitochondrial membrane potential, induction of autophagy and decrease of proliferation of C6 glioma cells. The compound's effect was comparable to that of rotenone, an inhibitor of cell respiration.