En busca de um tema esquecido: o lugar da educação nas recentes interpretações do Brasil
In: Araucaria: filosofía y ciencia, Heft 38, S. 345-366
ISSN: 2340-2199
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In: Araucaria: filosofía y ciencia, Heft 38, S. 345-366
ISSN: 2340-2199
In: Environmental science and pollution research: ESPR, Band 24, Heft 13, S. 11991-11997
ISSN: 1614-7499
In: Vernacular Architecture: Towards a Sustainable Future, S. 437-442
In: Environmental science and pollution research: ESPR, Band 24, Heft 1, S. 752-764
ISSN: 1614-7499
In: Materials & Design, Band 30, Heft 10, S. 4060-4068
In this study we assess the impact of a wide range of Portuguese domestic policies on cohesion in Portugal´s seven NUTS II regions. We focus mainly on regional economic cohesion, although social cohesion effects are also considered. We also look at whether the Portuguese regions have been able to share equitably in the country´s overall growth or whether there have been asymmetries and divergences in their growth patterns. While the purpose of the study is to analyse the policy impact of Community policies in two regions for reference. This is important for the case of Portugal where structural operations have been substantial and where European Union and national efforts seem to be highly intertwined.
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Resumen del trabajo presentado en el 25th EAA Annual Meeting: Beyond paradigms, celebrado en Bern (Suiza), del 4 al 7 de septiembre de 2019 ; Landscape evolution and environmental change in Lisbon have been addressed by the use of multi-proxy analysis, including pollen, non-pollen-palynomorphs and sedimentological data preserved in a sedimentary core retrieved in a sub-tidal area of the northern Tagus margin. Four radiocarbon dates indicate that the record covers from 1st century cal AD to late 6th century cal AD. Data cross-check with available archaeological information of the city enables for the reconstruction of palaeoenvironmental dynamics during circa 600 yr period at high resolution. Main results evidence that the area of Lisbon was an open landscape with little woodlands and high human impact at least since the 1st century cal AD. A higher influence of human activity has been identified in early 3rd century cal AD. A change in the sedimentary record has been identified in early 3rd century cal AD that can be related with natural events or higher human activity. A marked sedimentological change occurred in early 4th century AD, coincident with the late Roman period, and suggesting a change in the behaviour of the Tagus tributaries. A new phase of increase human impact has been identified in late 5th century cal AD. The diverse rhythms of environmental change occurred in accordance with social and political evolution of the area and evidence the usefulness of transdisciplinary and multi-proxy approach in landscape archaeology studies.
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In: Environmental science and pollution research: ESPR, Band 22, Heft 7, S. 5500-5510
ISSN: 1614-7499
Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported by the shuttling receptor PEX5 to the peroxisomal membrane docking/translocation machinery, where they are translocated into the organelle matrix. Under certain experimental conditions this protein import machinery has the remarkable capacity to accept already oligomerized proteins, a property that has heavily influenced current models on the mechanism of peroxisomal protein import. However, whether or not oligomeric proteins are really the best and most frequent clients of this machinery remain unclear. In this work, we present three lines of evidence suggesting that the peroxisomal import machinery displays a preference for monomeric proteins. First, in agreement with previous findings on catalase, we show that PEX5 binds newly synthesized (monomeric) acyl-CoA oxidase 1 (ACOX1) and urate oxidase (UOX), potently inhibiting their oligomerization. Second, in vitro import experiments suggest that monomeric ACOX1 and UOX are better peroxisomal import substrates than the corresponding oligomeric forms. Finally, we provide data strongly suggesting that although ACOX1 lacking a peroxisomal targeting signal can be imported into peroxisomes when co-expressed with ACOX1 containing its targeting signal, this import pathway is inefficient. ; This work was funded by Fundo Europeu de Desenvolvimento Regional (FEDER) through the Operational Competitiveness Programme (COMPETE); by National Funds through Fundação para a Ciência e a Tecnologia (FCT) under the project FCOMP-01–0124-FEDER-022718 (PEst-C/SAU/LA0002/2011) and FCOMP-01–0124-FEDER-019731 (PTDC/BIABCM/118577/2010); by Portuguese National Mass Spectrometry Network (RNEM) through the project REDE/1504/REM/2005; and by Química Orgânica, Produtos Naturais e Agroalimentares (QOPNA) research unit funds provided by FCT, European Union, QREN, FEDER and COMPETE under the projects PEst-C/QUI/UI0062/2013 and FCOMP-01–0124-FEDER-037296. M.O.F., T.F., T.A.R., M.P.P. and C.P.G. were supported by FCT, Programa Operacional Potencial Humano (POPH) do Quadro de Referência Estratégico Nacional (QREN) and Fundo Social Europeu. The work done in Leuven was supported by grants from the 'Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (Onderzoeksproject G.0754.09)' and the KU Leuven (OT/14/100).
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This work has been supported by Fundação para a Ciência e a Tecnologia (FCT) through Grant no. PEst-C/EQB/LA0006/2013, by bilateral project E-38/12 Acções Integradas Luso-Espanholas 2012, Spanish Government through PRI-AIBPT-2011-0769 (International Projects, Acciones integradas luso-españolas) and CTQ2012- 31157; and GMOsensor project of International Research Staff Exchange Scheme (FP7) PEOPLE-2013-IRSES (Marie Curie actions)
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Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs). Conclusions and Relevance The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
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