Suchergebnisse

The article assesses the official leaders of the country for more than a century of national history. The students review Russian history. The author does not take the position of an outside observer. He solves two problems. On the one hand, the work speaks of the leaders of the state from the point of view of the younger generation, and on the other hand the author himself analyzes certain moments of the history and the respondents themselves. The main criteria in the activities of the top officials of Russia and the USSR are qualities that characterize the degree of their competence in such parameters as achievements in economic development, solving acute political problems in their country and the world, strengthening the defense capability of the state, progress in the social sphere, progress in science, education, medicine, improving people's quality of life. In the conclusions to all presented material acute and topical questions are raised as to why many historical facts are not well known in the youth environment and what conclusions should be drawn on the basis of this sociological research by teachers of humanitarian disciplines, not only for the expansion of students' knowledge, but also for the formation of appropriate civil position. ; В статье дается оценка деятельности официальных лидеров страны за более чем столетний период отечественной истории, взгляд студентов вузов на российскую историю. Автор не занимает позицию стороннего наблюдателя, решает две задачи. С одной стороны, в работе говорится о руководителях государства с точки зрения молодого поколения, а с другой — автор анализирует определенные моменты истории и самих респондентов. Основными критериями в деятельности первых лиц России и СССР выступают качества, характеризующие степень их компетентности по таким параметрам, как достижения в экономическом развитии, решение острых политических проблем в своей стране и мире, укрепление обороноспособности государства, успехи в социальной сфере, прогресс в науке, образовании, медицине, улучшение качества жизни людей. В выводах поставлены острые и актуальные вопросы: почему многие исторические факты малоизвестны в молодежной среде и какие выводы должны сделать на основе этого социологического исследования преподаватели гуманитарных дисциплин не только для расширения знаний студентов, но и для формирования у них соответствующей гражданской позиции.

Relevance. In the context of the formation of a multipolar world and the increasing sanctions pressure from unfriendly countries, Russia needs to adjust the models of integration into the system of world economic relations. In this context, an in-depth analysis of the mechanisms of internationalization, globalization and regionalization is required.The purpose is to consider the peculiarities of the impact of globalization and regionalization processes on national economies, taking into account the transformation of their internationalization models.Objectives: to consider the concepts of internationalization, regionalization and globalization, to identify their relationship; to identify the advantages and disadvantages of globalization, on the basis of which to describe the directions of transformation of forms of internationalization of economies; based on the analysis of available statistical data, to identify promising areas of integration of the national economy into the system of world economic relations.Methodology. The methods of quantitative and qualitative analysis, monographic and retrospective analysis, methods of comparing economic phenomena and processes, methods of abstraction, generalization of analyzed economic information are used.Results. The internationalization of national economies is a long-term sustainable trend. Their development is confirmed by sufficiently convincing quantitative data. Recently, the dynamics of the corresponding time series has become unstable, volatile and turbulent, with a tendency to decrease the level of indicators. There are transformations of the processes of globalization and regionalization, they acquire not only a new quality, but also institutional consolidation.Conclusions. The traditional model of globalization has exhausted itself. Due to the formation of a multipolar political and economic global space, in addition to the "center" and "periphery", countries of the "semi-periphery" stand out in it. They have sufficient economic sovereignty to refuse to participate in globalization projects, the balance of effects of which for these countries becomes negative. Russia is one of these countries. An additional incentive for reconfiguring the Russian model of internationalization of the economy is the anti-Russian sanctions imposed by the countries of the "center". In this regard, it is necessary to open up new opportunities for the national economy to integrate into the global economic space based on models of regionalization and glocalization.

The legal foundation of a society is the basis of its existence and effective functioning. The legal consciousness occupies a special place in it. It acts as an integral part of people's worldview, their life orientations, values and priorities. In Russia, the dynamics of the ongoing changes in the political and legal sphere is largely determined by the rethinking of the events of the recent past and the attempt by various forces of influence to comprehend the present adequately. Such close attention to the phenomenon of legal awareness is due to many changes taking place in the country and society. The consciousness of people in Russia is multipolar. Both internal and external factors influence on its formation, more often they are of a destructive nature. For example, the role of the hybrid war, which has been waged against Russia throughout its recent history and in which young people are actively involved, is great. Attempts to organize and conduct various actions with the participation of young people expose, among other things, the problems of our society, the state of legal awareness of young people involved in these events. This puts forward new tasks for working with young people, primarily students. The article reveals the concept of legal consciousness, considers its structure and types. The authors pay special attention to the сharacterization of the features of the modern legal consciousness in Russia. The article also characterizes legal socialization. Legal consciousness manifests itself in behavior. The authors rely on the results of the study on the legal behavior of young people. The presented factual material makes it possible to identify the cause-and-effect relationships between the legal consciousness and the factors affecting it. The article provides possibilities for the interested persons to use the presented theoretical and practical material in their work on the formation of the legal consciousness of modern Russian youth. ; Введение. Правовой фундамент общества является основой его существования и эффективного функционирования. В нем особое место занимает правосознание, которое выступает неотъемлемой частью мировоззрения людей, их жизненных ориентиров, ценностей и приоритетов. В России динамика происходящих перемен в политико-правовой сфере во многом детерминирована переосмыслением событий недавнего прошлого и попыткой со стороны различных сил влияния адекватно осмыслить настоящее. Столь пристальное внимание к феномену правосознания обусловлено многими изменениями, происходящими в стране и обществе. Сознание людей в России многополярно. Оно формируется под влиянием как внутренних, так и внешних факторов, чаще всего носящих деструктивный характер. Велика, например, роль гибридной войны, которая ведется против России на протяжении всей ее новейшей истории и в которую активно вовлекается молодежь. Попытки организовать и провести различные акции с участием молодежи обнажают в том числе проблемы нашего общества, состояние правосознания молодежи, вовлеченной в эти события. Это выдвигает новые задачи по работе с молодежью, прежде всего студенческой. Постановка задачи. В статье раскрывается понятие правосознания, рассматривается его структура и виды. Методология и методика исследования. Особое внимание уделяется характеристике особенностей современного правосознания в России. Результаты. Наряду с правосознанием дана характеристика правовой социализации. Правовое сознание проявляется в поведении. Авторы опираются на результаты исследования по изучению правового поведения молодежи. Представленный фактический материал дает возможность выявить причинно-следственные связи между правосознанием и факторами, на него воздействующими. Выводы. Статью следует рассматривать с точки зрения возможностей, которые дает представленный теоретический и практический материал. Он может быть использован в работе заинтересованных лиц по формированию правосознания современной российской молодежи.

Hypercytokinemia, or cytokine storm, is one of the severe complications of viral and bacterial infections, involving the release of abnormal amounts of cytokines, resulting in a massive inflammatory response. Cytokine storm is associated with COVID-19 and sepsis high mortality rate by developing epithelial dysfunction and coagulopathy, leading to thromboembolism and multiple organ dysfunction syndrome. Anticoagulant therapy is an important tactic to prevent thrombosis in sepsis and COVID-19, but recent data show the incompatibility of modern direct oral anticoagulants and antiviral agents. It seems relevant to develop dual-action drugs with antiviral and anticoagulant properties. At the same time, it was shown that azolo[1,5-a]pyrimidines are heterocycles with a broad spectrum of antiviral activity. We have synthesized a new family of azolo[1,5-a]pyrimidines and their condensed polycyclic analogs by cyclocondensation reactions and direct CH-functionalization and studied their anticoagulant properties. Five compounds among 1,2,4-triazolo[1,5-a]pyrimidin-7-ones and 5-alkyl-1,3,4-thiadiazolo[3,2-a]purin-8-ones demonstrated higher anticoagulant activity than the reference drug, dabigatran etexilate. Antithrombin activity of most active compounds was confirmed using lipopolysaccharide (LPS)-treated blood to mimic the conditions of cytokine release syndrome. The studied compounds affected only the thrombin time value, reliably increasing it 6.5–15.2 times as compared to LPS-treated blood. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. ; Funding: This research was funded within the framework of the grant agreement as government subsidies from the federal budget in accordance with paragraph 4 of article 78.1 of the Budget Code of the Russian Federation (Moscow, 1 October 2020, No. 075-15-2020-777).