Suchergebnisse

Magnesium alloys represent a new research direction in the field of orthopedic resorbable metal materials, because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. From in vitro studies, Magnesium has osteoconductive properties, promoting the formation of new bone by stimulating the adhesion of osteoblastic cells, this leading to the idea that it will induce formation of hard callous at fracture site. The present study followed the in vivo evaluation of the biodegradation of pins made of Mg-1Ca alloy introduced centromedulary in rabbit tibiae, with previously induced experimental fractures. The influence of the biodegradation process on the formation of the bone callus was evaluated through radiological images and histopathological examinations. At the same time, we evaluated the function of vital organs through histopathological examinations and blood tests. We chose intramedulary nailing (IMN) with pins, because in orthopaedic surgery this is the golden standard for fractures of tibia or femur. In the radiological images obtained, we notice callus formation at the level of the experimental fracture at 6 weeks after surgery. The histological sections made from the samples collected from the fracture zone adjacent to the Mg1Ca alloy implant, confirm the formation of the bony callus. The trichrome Masson sections show a normal bone development with newly formed bone tissue at the tissue - alloy interface. In the sections harvested from the vital organs, no pathological changes are observed. These observations suggest that the biodegradation process of the Mg-1Ca alloy do not interfere negatively with the biological process of bone formation, allowing the formation of the bone callus and do not confirm the suspicion of pathological changes induced by systemically released corrosion products and gas embolism in vital organs.