Biofluid Metabolomics in Preterm Birth Research
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 7, S. 967-977
ISSN: 1933-7205
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In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 7, S. 967-977
ISSN: 1933-7205
In: International journal of sustainable development & world ecology, Band 30, Heft 6, S. 605-619
ISSN: 1745-2627
In: Revista de movimentos sociais e conflitos, Band 8, Heft 2
ISSN: 2525-9830
O presente artigo pretende responder a uma indagação principal: vivemos, no Brasil, uma democracia de alta intensidade, na perspectiva da participação das mulheres negras nos espaços de decisão política? Para responder a esta indagação, partiu-se do conceito clássico de democracia como governo do povo, que é, inclusive, adotado pela Constituição da República de 1988, como decorre do art. 1º, caput, incisos II e V e parágrafo único, e foi concluído que uma parcela substancial do "povo", qual seja, a composta pelas mulheres negras, foi excluída, por uma série de fatores, do "povo" titular do poder soberano, o que autoriza afirmar que não vivemos no Brasil uma democracia de alta intensidade, acrescentando-se que a não criação das condições para que as mulheres negras participem dos espaços formais de decisão política resulta em um verdadeiro estado de coisa inconstitucional. Partindo das conclusões acima enunciadas, foram apontadas possíveis medidas que favorecem a participação política das mulheres negras e promovam o seu empoderamento político.
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/PGPM.S170515
Jubby Marcela Galvez,1 Carlos Martin Restrepo,1 Nora Constanza Contreras,1 Clara Alvarado,1 Carlos-Alberto Calderón-Ospina,1 Nidia Peña,1 Ricardo A Cifuentes,2 Daniela Duarte,1 Paul Laissue,1 Dora Janeth Fonseca1 1GENIUROS Research Group, Center For Research in Genetics and Genomics – CIGGUR, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; 2Area of Basic Sciences, College of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia Purpose: Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter- and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 and VKORC1 gene polymorphisms affect warfarin metabolism and dosage. Due to the central role of populations' ethnical and genetic origin on warfarin dosage variability, novel algorithms for Latin American subgroups are necessary to establish safe anticoagulation therapy.Patients and methods: We genotyped CYP2C9*2 (c.430C > T), CYP2C9*3 (c.1075A > C), CYP4F2 (c.1297G > A), and VKORC1 (-1639 G > A) polymorphisms in 152 Colombian patients who received warfarin. We evaluated the impact on the variability of patients' warfarin dose requirements. Multiple linear regression analysis, using genetic and non-genetic variables, was used for creating an algorithm for optimal warfarin maintenance dose.Results: Median weekly prescribed warfarin dosage was significantly lower in patients having the VKORC1-1639 AA genotype and poor CYP2C9*2/*2,*2/*3 metabolizers than their wild-type counterparts. We found a 2.3-fold increase in mean dose for normal sensitivity patients (wild-type VKORC1/CYP2C9 genotypes) compared to the other groups (moderate and high sensitivity); 31.5% of the patients in our study group had warfarin sensitivity-related genotypes. The estimated regression equation accounted for 44.4% of overall variability in regard to warfarin maintenance dose. The algorithm was validated, giving 45.9% correlation (R2=0.459).Conclusion: Our results describe and validate the first algorithm for predicting warfarin maintenance in a Colombian mestizo population and have contributed toward the understanding of pharmacogenetics in a Latin American population subgroup.Keywords: genetic polymorphism, adverse drug reaction, gene frequency, anticoagulants
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