Suchergebnisse

AbstractAlthough waste‐to‐energy (WtE) incineration projects have boosted the economic effectiveness of the waste management system, locals frequently view them with suspicion, opposition, or even outright rejection because of potential environmental and health risks. In this study, by incorporating two additional variables, namely, objective knowledge and benefit perceptions, the planned risk information seeking model (PRISM) was extended in the context of the WtE incineration project. A total of 1726 respondents were interviewed in person. Results from the structural equation modeling indicated that the extended PRISM achieved excellent fits, suggesting the generalizability of the model in these contexts. Objective knowledge and subjective knowledge have a positive and direct impact on perceived knowledge insufficiency. The impact of benefit and risk perceptions on worry is the opposite, with risk perceptions having a greater direct effect on worry. However, compared with risk perceptions, the direct effect that benefit perceptions have on perceived knowledge insufficiency is stronger. Additionally, perceived knowledge insufficiency partially or completely mediates the relationships between all antecedents, except perceived seeking control, and information‐seeking intention. This study suggests that risk managers carefully consider how to establish powerful communication tactics to shape these antecedents when introducing a "not in my backyard" project to the local community.

AbstractBreast cancer resistance protein (BCRP/ABCG2) is a critical drug efflux transporters by limiting drugs' transplacental transfer rates. More investigations on the regulation of placental BCRP offer great promise for enabling pronounced progress in individualized and safe pharmacotherapy during pregnancy. Histone deacetylases (HDACs) play an important role in epigenetic regulation of placental genes. It was reported recently by us that HDAC1 was involved in placental BCRP regulation in vitro. The aim of this study was to further explore the effect of HDAC1 on placental BCRP expression and functionality in animals. Randomly assigned C57BL pregnant dams received intraperitoneal injections of a negative control siRNA or Hdac1 siRNA from embryonic day 7.5 (E7.5) to E15.5, respectively. At E16.5, glyburide (GLB), a probe for evaluating placental BCRP efflux functionality, was injected via the tail vein. Animals were sacrificed through cervical dislocation at various times (5–180 min) after drug administration. The maternal blood, placentas, and fetal-units were collected. GLB concentrations were determined by a validated high-performance liquid chromatography/mass spectrometry (HPLC-MS) assay. Real-time quantitative PCR (qRT-PCR), Western blot, and immunohistochemical (IHC) analysis were employed to identify mRNA/protein levels and localization of gene expressions, respectively. It was noted that Hdac1 inhibition significantly decreased placental Bcrp expression, with markedly increases of GLB concentrations and area under the concentration-time curve (AUC) in fetal-units. Particularly, the ratios of fetal-unit/maternal plasma GLB concentrations were also significantly elevated following Hdac1 repression. Taken together, these findings suggested that HDAC1 was involved in positive regulation of placental BCRP expression and functionality in vivo.

The existence of glacial lakes in the Southeastern Tibetan Plateau (SETP) is a potential hazard to the downstream regions, as the failure of some lakes has potential to result in disastrous glacial lake outburst flood (GLOF) events of high-magnitude. In the present study, we conducted a comprehensive investigation for Bienong Co, an end moraine-dammed glacial lake in SETP, including its area evolution analysis, basin morphology simulation, water volume estimation, possible outburst triggers analysis, and one- and two-dimensional hydrodynamic simulation. The results show that the area of Bienong Co was 1.15 ± 0.05 km 2 in August 2020, which has remained generally stable over the past four decades. However, it exhibits the high risk of GLOFs due to its larger area, the steep and high moraine dam, the close distance to its mother glacier, and the surrounding steep slopes. The lake basin is relatively flat at bottom and steep on both flanks, and the slope near the glacier (16.5°) is steeper than that near the moraine dam (11.3°), with a maximum lake depth of ~181.04 m and a water volume of ~1.02 × 10 8 m 3 in August 2020. Four scenarios of GLOFs based on different breach depths, breach widths and failure times were simulated using the hydrodynamic model of MIKE 11 and MIKE 21 to predict the potential impacts on downstream areas. An extreme-magnitude GLOF would have a catastrophic impact on the downstream region, with most of the settlements, all bridges and majority of Jiazhong Highway along the flow channel being completely submerged. However, in a low-magnitude GLOF, most settlements would be safe or partially inundated. It means that most of the residents in the flow channel of Bienong Co can avoid the damage caused by a low-magnitude GLOF (smaller breach depth of dam). Although three settlements in the downstream area are at risk of being completely submerged in a low-magnitude GLOF event, the flooding arrives late and people have enough time to escape. Finally, the maximum depths of glacial lakes with similar areas were compared for 16 glacial lakes with measured bathymetry data in the Himalayas and Bienong Co in SETP, according to the regional division of maritime and continental zones. The results show that glacial lakes located in maritime regions have larger depths than those in continental regions, and Bienong Co is the deepest glacial lake comparing others in the Himalayas. Therefore, a huge amount of water could be discharged by a potential GLOF event of Bienong Co, creating a serious hazard, which should be taken seriously in the future. Overall, this study of Bienong Co could provide a new understanding of the moraine-dammed glacial lakes in the SETP and a reference of GLOFs to the local government.