Aufsatz(elektronisch)#12020
Synthesis, antimicrobial activity, urease inhibition and molecular docking studies of new proline linked thiourea derivatives
In: Revue roumaine de chimie: Romanian journal of chemistry, Band 65, Heft 9, S. 783-788
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; RAHEEL, Ahmad; DIN, Imtiaz-Ud; IFTIKHAR, Syed Hassan; TAJ, Muhammad Babar; AYUB, Rabia; ZAFAR, Anham; ABBAS, Sumaira
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; RAHEEL, Ahmad; DIN, Imtiaz-Ud; IFTIKHAR, Syed Hassan; TAJ, Muhammad Babar; AYUB, Rabia; ZAFAR, Anham; ABBAS, Sumaira; AL-SHAKBAN, Mundher; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Chemistry, University of Engineering and Technology, Lahore 54890, Pakistan; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691, Stockholm, Sweden; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Chemistry, University of Manchester, M13 9PL, England
A series of new thiourea based carboxylic acids (Ia-Ie) were synthesized and characterized by elemental analysis, FTIR and NMR (1 H and 13C) spectroscopy. They were preliminary bioassayed for their antibacterial, anifungal and urease inhibition activities. Molecular docking simulations were carried out to determine the probable binding mode of the synthesized compounds. The bioassay results showed that some of titled compounds exhibited encouraging results.