Suchergebnisse

The proposers of resolution 21 at the 1986 AGM initially called for absolute discharges to be recommended for the offence of loitering. The motion was subsequently amended after reservations were expressed as to the possible repercussions of such a strategy. They here argue the merits of their original proposal.

AbstractIntroduction: With increasing survival of vertically HIV‐infected children and ongoing new horizontal HIV infections, the population of adolescents (age 10–19 years) living with HIV is increasing. This review aims to describe the epidemiology of the adolescent HIV epidemic and the ability of national monitoring systems to measure outcomes in HIV‐infected adolescents through the adolescent transition to adulthood.Methods: Differences in global trends between younger (age 10–14 years) and older (age 15–19 years) adolescents in key epidemic indicators are interrogated using 2016 UNAIDS estimates. National population‐based survey data in the 15 highest adolescent HIV burden countries are evaluated and examples of national case‐based surveillance systems described. Finally, we consider the potential impact of adolescent‐specific recommendations in the 2016 WHO Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection.Discussion: UNAIDS estimates indicate the population of adolescents living with HIV is increasing, new HIV infections in older adolescents are declining, and while AIDS‐related deaths are beginning to decline in younger adolescents, they are still increasing in older adolescents. National population‐based surveys provide valuable estimates of HIV prevalence in older adolescents and recent surveys include data on younger adolescents. Only a few countries have nationwide electronic case‐based HIV surveillance, with the ability to provide population‐level data on key HIV outcomes in the diagnosed population living with HIV. However, in the 15 highest adolescent HIV burden countries, there are no systems tracking adolescent transition to adulthood or healthcare transition. The strength of the 2016 WHO adolescent‐specific recommendations on antiretroviral therapy and provision of HIV services to adolescents was hampered by the lack of evidence specific to this age group.Conclusions: Progress is being made in national surveillance and global monitoring systems to specifically identify trends in adolescents living with HIV. However, HIV programmes responsive to the evolving HIV prevention and treatment needs of adolescents can be facilitated further by: data disaggregation to younger and older adolescents and mode of HIV infection where feasible; implementation of tools to achieve expanded national case‐based surveillance; streamlining consent/assent procedures in younger adolescents and consensus on indicators of adolescent healthcare transition and transition to adulthood.

ObjectivesTo date South Africa has experienced four distinct COVID-19 waves due to ancestral, Beta, Delta and Omnicron SARS-CoV-2 variants. We sought to answer pertinent public health questions in a timely manner as new COVID-19 variants emerge(d) using routine health service data linked through a service-facing health information exchange (HIE).
ApproachA population cohort was defined amongst regular health service users in the Western Cape Province of South Africa based on recent utilisation of public sector services as reflected in the Provincial Health Data Centre (PHDC) which functions as a HIE. Infection, hospitalisation and mortality data were derived from routinely linked laboratory, service and national vital registration data sources. Serology done on residual specimens of patients monitored for HIV and diabetes treatment progress were linked to the PHDC, as were vaccination data from the national vaccination information system. A single linked and de-identified dataset was exported for analysis purposes.
ResultsBased on accessing services in the preceding 3 years, a cohort of 3.5 million adult patients could be enumerated and linked to co-morbidity and SARS-CoV-2 outcome data. Serology from 16,000 specimens spread across the three inter-wave periods, and vaccine data from amongst the 5 million vaccine doses given in the Province, could also be linked. Variants could be identified by wave or by PCR assay target anomalies during cross-over periods. Publishable variant severity analyses were feasible from the sub-cohort of patients with diagnosed COVID-19, and variant-specific vaccine effectiveness was assessible amongst cases, in the population cohort, and in patients with HIV. The impact of prior infection and marginal value of vaccination in those with prior infection was assessible within the serology sub-cohort.
ConclusionA single linked de-identified dataset derived from an operational HIE was able to quickly address critical public health questions related to COVID-19 variants in a privacy-preserving manner.