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We would like to thank Mar Bastero, Adrian Carmona, Mikael R. Chala, Miguel Escud-ero, Javier Olmedo, Jose Santiago and Samuel Witte for discussions. This work was par-tially supported by the Spanish Ministry of Science, Innovation and Universities (PID2019-107844GB-C21/AEI/10.13039/501100011033) and by the Junta de Andalucia (FQM 101, SOMM17/6104/UGR, P18-FR-1962, P18-FR-5057) . ; We propose a singlet majoron model that defines an inverse seesaw mechanism in the v sector. The majoron phi has a mass m(phi) approximate to 0.5 eV and a coupling to the tau lepton similar to the one to neutrinos. In the early universe it is initially in thermal equilibrium, then it decouples at T approximate to 500 GeV and contributes with just Delta N-eff = 0.026 during BBN. At T = 26 keV (final stages of BBN) a primordial magnetic field induces resonant gamma phi oscillations that transfer 6% of the photon energy into majorons, implying Delta N-eff = 0.55 and a 4.7% increase in the baryon to photon ratio. At T approximate to m(phi) the majoron enters in thermal contact with the heaviest neutrino and it finally decays into v (v) over bar pairs near recombination, setting Delta N-eff = 0.85. The boost in the expansion rate at later times may relax the Hubble tension (we obtain H-0 = (71.4 +/- 0.5) km/s/Mpc), while the processes v (v) over bar phi suppress the free streaming of these particles and make the model consistent with large scale structure observations. Its lifetime and the fact that it decays into neutrinos instead of photons lets this axion-like majoron avoid the strong bounds that affect other axion-like particles of similar mass and coupling to photons. ; Spanish Government PID2019-107844GB-C21/AEI/10.13039/501100011033 ; Junta de Andalucia FQM 101 SOMM17/6104/UGR P18-FR-1962 P18-FR-5057

Synchrotron X-ray diffraction and inelastic neutron scattering measurements have been applied to evaluate the breathing phenomena in small nanocrystals of ZIF-7 upon gas adsorption. The experimental results show that an extended solvent exchange process with methanol is crucial to get a solvent-free narrow pore structure. Under these conditions, nano-ZIF-7 is indeed able to adsorb N2 with a total BET surface area of around 380 m2 g−1, in close agreement with theoretical predictions. The breathing phenomenon upon nitrogen adsorption is accompanied by a phase-to-phase transition, from a narrow-pore (phase II) to a large-pore (phase I) structure and a suppression of the cooperative deformation of the framework involving mainly the flapping motion of the benzimidazolate (bIm) ligand with the 4- and 6-membered rings. Whereas nitrogen requires temperature and pressure conditions close to condensation (close to 1 bar and 77 K) to induce the breathing in ZIF-7, CO2 can do it under milder conditions (at room temperature and low relative pressures). These results reflect that the nature of the adsorptive probe and the gas–framework interactions, rather than the molecular diameter and/or shape, play a crucial role in defining the pressure and temperature conditions required to induce the breathing. The presence of two different cavities in ZIF-7 as suggested by theoretical predictions, one with a window diameter of below 0.4 nm (cavity A) and the other with a pore size of around 0.6 nm (cavity B), has been confirmed experimentally using immersion calorimetry. ; J. S. A. and C. C. C. acknowledge financial support from the University of Alicante (ACIE16-04) to cover all the expenses for the INS measurements at ORNL. J. S. A. gratefully acknowledges financial support from MINECO (MAT2016-80285-p), European Union H2020 (MSCA-RISE-2016/NanoMed Project) and Generalitat Valenciana (PROMETEOII/2014/004), Spanish ALBA synchrotron for beam time availability (Project ID: 2016021724) and Oak Ridge beam time availability (Project ID: IPTS-16291.1).

13 p.-5 fig.-1 tab. ; Nowadays, treatment of food allergy only considered the avoidance of the specific food. However, the possibility of cross-reactivity makes this practice not very effective. Immunotherapy may exhibit as a good alternative to food allergy treatment. The use of hypoallergenic molecules with reduced IgE binding capacity but with ability to stimulate the immune system is a promising tool which could be developed for immunotherapy. In this study, threemutants of Pru p 3, the principal allergen of peach,were produced based on the described mimotope and T cell epitopes, by changing the specific residues to alanine, named as Pru p 3.01, Pru p 3.02,and Pru p 3.03. Pru p 3.01 showed very similar allergenic activity as the wild type by in vitro assays. However, Pru p 3.02 and Pru p 3.03 presented reduced IgE binding with respect to the native form, by in vitro, ex vivo, and in vivo assays. In addition, Pru p 3.03 had affected the IgG4 binding capacity and presented a random circular dichroism, which was reflected in the nonrecognition by specific antibodies anti-Pru p 3. Nevertheless, both Pru p 3.02 and Pru p 3.03 maintained the binding to IgG1 and their ability to activate T lymphocytes.Thus, Pru p 3.02 and Pru p 3.03 could be good candidates for potential immunotherapy in peach-allergic patients. ; Financial support from the Ministerio de Ciencia e Innovación (Grant BIO2009-07050) and the Instituto de Salud Carlos III, RETICS 2007 (RD07/0064/03), Spain, are acknowledged. C. Gómez-Casado and L. Tordesillas were supported by training grants from the Spanish Government (FPI and FPU programmes, MEC, resp.). ; Peer reviewed

This study received economic support from the Spanish Ministry of Economic Affairs and Competitiveness, the Carlos III Health Care Institute (Grant Number PI11/00325, PI14/00612), the European Regional Development Fund, the European Union, "Una manera de hacer Europa/A Way of Shaping Europe", and CIBERSAM.

Objectives Neuritin 1 gene (NRN1) is involved in neurodevelopment processes and synaptic plasticity and its expression is regulated by brain-derived neurotrophic factor (BDNF). We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF. Methods The study was developed in a sample of 954 SSD/BPD patients and 668 healthy subjects. Genotyping analyses included 11 SNPs in NRN1 and one functional SNP in BDNF. Results The frequency of the haplotype C-C (rs645649–rs582262) was significantly increased in patients compared to controls (P = 0.0043), while the haplotype T-C-C-T-C-A (rs3763180–rs10484320–rs4960155–rs9379002–rs9405890–rs1475157) was more frequent in controls (P = 3.1 × 10−5). The variability at NRN1 was nominally related to changes in age at onset and to differences in intelligence quotient, in SSD patients. Epistasis between NRN1 and BDNF was significantly associated with the risk for SSD/BPD (P = 0.005). Conclusions Results suggest that: (i) NRN1 variability is a shared risk factor for both SSD and BPD, (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD, and (iii) the role of NRN1 seems to be not independent of BDNF. ; We are grateful to all the participants, whose willingness to take part made this work possible. We also thank Anna Valldeperas for her participation in molecular laboratory tasks. Funding for this study was provided by: i) Centro de Investigación en Red de Salud Mental (CIBERSAM), ii) Fundación Alicia Koplowitz; iii) Ministry of Science and Innovation (PIM2010ERN-00642)-ERA-NET NEURON; iv) P1·1B2010-40 and P1·1B2011-47 from the Fundació Bancaixa-UJI; v) Miguel Servet Research Contracts (CP10/00596) from the Plan Nacional de I + D+i and co-funded by the Instituto de Salud Carlos III-Subdirección General de Evaluación y Fomento de la Investigación and the European Regional Development Fund (FEDER); vi) Health research funds from the Spanish Government (PI11/01977); vii) METSY project of the 7th Framework Programme of the European Commission (FP7-HEALTH-602478) and Ministry of Economy and Competitiveness (PI10/01920, PI14/02096); Claudia Prats was supported by APIF-IBUB grant 2014. Thanks to the Comissionat per a Universitats i Recerca del DIUE (2014SGR1636, 2014SGR1573, 2014SGR489).

Background: Traumatic life events (TLEs) are one of the most robust environmental risk factors for the onset of first-episode psychosis (FEP). Aims: To explore TLEs in FEP patients and healthy controls (HC), to analyze gender differences and to examine whether TLEs were associated with sociodemographic, clinical and psychofunctional variables in all FEP sample and split by age. Methods: Descriptive and cross-sectional study. Three hundred and thirty-five FEP and 253 HC were recruited at 16 Spanish mental health research centers. The Traumatic Experiences in Psychiatric Outpatients Questionnaire was administered. Results: We found a higher number of TLEs in FEP than in HC, and the proportion of individuals with three or more TLEs was significantly higher in the FEP group. No differences were found in terms of gender and age. There was no relationship between total number of TLEs and psychotic symptomatology and functional outcomes. Conclusions: The number and cumulative TLEs should be taken into account in the detection, epidemiology and process of recovery in FEP.