Suchergebnisse

UIDB/04666/2020 UIDP/04666/2020 ; In the second half of the 17th century, more than in any other period of Portuguese history, royal weddings played an important role as vehicles for political propaganda in the consolidation of the Braganza dynasty. Among the marriages celebrated during that period, the union of King Peter II and Maria Sophia of Neuburg in 1687 was of particular significance. I intend to highlight some aspects of the involvement of architect Luís Nunes Tinoco (1642/3-1719) in the realisation of this royal wedding, especially with regard to the texts that he composed about the festivities. Those in which he writes about specific characteristics of the arts, especially architecture, are particularly pertinent, as is a decasyllabic poem entitled Triumpho da Real Fabrica e Pompa Luzitana, in which he also describes the arches erected for the occasion. This poem is published here in full for the first time ; publishersversion ; published

UID/HIS/04666/2019 ; In the second half of the 17th century, more than in any other period of the Portuguese History, royal weddings were an expression of regal power and a reference in the imaginary of the time. Playing an important role as political propaganda vehicles in the consolidation of the Braganza dynasty, they were also a privileged stage to present artistic solutions in a city that, due to its geographical characteristics, is itself a stage of a strong scenography. Of the marriages then celebrated took special importance the one of D. Afonso VI with Maria Francisca Isabel de Sabóia (1666) and in particular the one of D. Pedro II with Maria Sofia de Neuburgo (1687). In a decorative exuberance that invoked both national heroes and those of the other nations involved (along with the exaltation of the virtues of Lisbon), their ephemeral architectures, inspired by engravings and architectural treatises, were also potential models of inspiration for the architects themselves. Although the feasts of these marriages have already been approached by some authors, continuing our PhD research and the work we have been developing since then, we now intend to highlight some aspects of the participation of the architect Luís Nunes Tinoco (1642/3-1719) in the realization of the royal wedding celebrated in 1697, as architect, illustrator and writer. Describing in a detailed and unusual report the construction and decorative techniques of the arches and other ornaments, among the other texts he composed about these feasts are particularly relevant those he elaborated on the specific characteristics of the Arts, especially on Architecture, which in relation with other texts of his vast work are an essay for an architectural theory, similar to the essays he had written about Painting, already well known to us. ; publishersversion ; published

Abstract

Background Transthyretin amyloidosis (also known as ATTR amyloidosis) is a systemic, life-threatening disease characterized by transthyretin (TTR) fibril deposition in organs and tissue. A definitive diagnosis of ATTR amyloidosis is often a challenge, in large part because of its heterogeneous presentation. Although ATTR amyloidosis was previously considered untreatable, disease-modifying therapies for the treatment of this disease have recently become available. This article aims to raise awareness of the initial symptoms of ATTR amyloidosis among general practitioners to facilitate identification of a patient with suspicious signs and symptoms. Methods These consensus recommendations for the suspicion and diagnosis of ATTR amyloidosis were developed through a series of development and review cycles by an international working group comprising key amyloidosis specialists. This working group met to discuss the barriers to early and accurate diagnosis of ATTR amyloidosis and develop a consensus recommendation through a thorough search of the literature performed using PubMed Central. Results The cardiac and peripheral nervous systems are most frequently involved in ATTR amyloidosis; however, many patients often also experience gastrointestinal and other systemic manifestations. Given the multisystemic nature of symptoms, ATTR amyloidosis is often misdiagnosed as a more common disorder, leading to significant delays in the initiation of treatment. Although histologic evaluation has been the gold standard to confirm ATTR amyloidosis, a range of tools are available that can facilitate early and accurate diagnosis. Of importance, genetic testing should be considered early in the evaluation of a patient with unexplained peripheral neuropathy. Conclusions A diagnostic algorithm based on initial red flag symptoms and manifestations of cardiac or neurologic involvement will facilitate identification by the general practitioner of a patient with clinically suspicious symptoms, enabling subsequent referral of the patient to a multidisciplinary specialized medical center.