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More and more research in recent years has focused on neurogenesis and neuroplasticity. The hippocampus is a key location of adult neurogenesis. Because this part of the brain is regulated by environmental variables, it must be mentioned the therapeutic potential for neurodegenerative illnesses and brain injuries. Furthermore, this information challenges the historical concept of a static brain and tries to demonstrate its flexibility, adaptability, and possibility for regeneration. Those mechanisms which are found in a variety of mammalian species, including humans, are important when it comes to adaptive learning and memory, thus providing insights into cognitive well-being and mental health. The discovery of the brain's dynamic nature represented by new neurons, marks a shift in the field of neurology with far-reaching potentials. This paper highlights the significant potential of adult neurogenesis when it comes to clinical applications such as Alz-heimer's disease.

Background. Primary headaches are comprised of three big categories: migraines (with or without aura), the third most
common and the 6th most disabling disease worldwide, tension-headaches, and trigeminal autonomic cephalalgias, each with
different, complex, and not completely understood pathophysiological, clinical, and neuroimagistic characteristics. Structures like
the brain stem, hippocampus, or hypothalamus have been depicted as being the main triggers of these types of headaches, which
have a significant impact on the quality of life. Methods. We performed a broad literature review on primary headaches from
January 2016 to June 2023, analyzing the latest scientific updates and emphasizing the pathophysiological and neuroimagistic
characteristics. Results. We provide a concise review of the main neuroimaging studies that help in differential diagnosis between
several types of primary headaches. Conclusions. It is difficult to approach the pathophysiology of these three primary headache
categories. Keeping in mind that neuroimagistic methods are rapidly developing (especially in the MRI sphere), the most
important endpoint of future studies will be to establish a reliable distinction system for all these types of cephalalgias, thus
updating the protocols and guidelines. Currently, imaging studies are indicated only in certain circumstances.