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AbstractThis article traces how the 'wet' market was integrated into the infrastructure of public housing estates in Hong Kong through modularization from 1969 to 1975. This includes how spatial modularization concepts extended into administration and management, incorporating responsibilities and categories of goods that ultimately reflected colonial ideas of health, food hygiene and social and spatial order. In doing so, this article theorizes how the modular market embodied the ways colonial government departments, architects and managers navigated notions of the materiality of 'wetness' in the market through its design in response to management and customer needs, but nevertheless how consumers found ways to re-narrate such spaces through maintaining 'wet' cultural exchanges and practices. Using government documents and photographs, this article combines a design historical approach to materiality with empirical evidence to expand on histories and practices of the 'wet market', bringing the everyday discourses of modernity in Hong Kong to the fore.

OBJECTIVES: Three hundred million people living with rare diseases worldwide are disproportionately deprived of in-time diagnosis and treatment compared with other patients. This review provides an overview of global policies that optimize development, licensing, pricing, and reimbursement of orphan drugs. METHODS: Pharmaceutical legislation and policies related to access and regulation of orphan drugs were examined from 194 World Health Organization member countries and 6 areas. Orphan drug policies (ODPs) were identified through internet search, emails to national pharmacovigilance centers, and systematic academic literature search. Texts from selected publications were extracted for content analysis. RESULTS: One hundred seventy-two drug regulation documents and 77 academic publications from 162 countries/areas were included. Ninety-two of 200 countries/areas (46.0%) had documentation on ODPs. Thirty-four subthemes from content analysis were categorized into 6 policy themes, namely, orphan drug designation, marketing authorization, safety and efficacy requirements, price regulation, incentives that encourage market availability, and incentives that encourage research and development. Countries/areas with ODPs were statistically wealthier (gross national income per capita = $10 875 vs $3950, P < .001). Country/area income was also positively correlated with the scope of the respective ODP (correlation coefficient = 0.57, P < .001). CONCLUSIONS: Globally, the number of countries with an ODP has grown rapidly since 2013. Nevertheless, disparities in geographical distribution and income levels affect the establishment of ODPs. Furthermore, identified policy gaps in price regulation, incentives that encourage market availability, and incentives that encourage research and development should be addressed to improve access to available and affordable orphan drugs.