Suchergebnisse

[Background and objective] We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the SITS–International Stroke Thrombectomy Register (SITS-ISTR) and compare them with pooled randomized controlled trials (RCTs) and two national registry studies. ; [Methods] We identified centres recording ≥10 consecutive patients in the SITS-ISTR with at least 70% of available modified Rankin Scale (mRS) at 3 months during 2014–2019. We defined large artery occlusion as intracranial internal carotid artery, first and second segment of middle cerebral artery and first segment of anterior cerebral artery. Outcome measures were functional independence (mRS score 0-2) and death at 3 months and symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST. ; [Results] Results are presented in the following order: SITS-ISTR, RCTs, MR CLEAN Registry and German Stroke Registry (GSR). Median age was 73, 68, 71 and 75 years; baseline NIHSS score was 16, 17, 16 and 15; prior intravenous thrombolysis was 62%, 83%, 78% and 56%; onset to reperfusion time was 289, 285, 267 and 249 min; successful recanalization (mTICI score 2b or 3) was 86%, 71%, 59% and 83%; functional independence at 3 months was 45.5% (95% CI: 44–47), 46.0% (42–50), 38% (35–41) and 37% (35–41), respectively; death was 19.2% (19–21), 15.3% (12.7–18.4), 29.2% (27–32) and 28.6% (27–31); and SICH was 3.6% (3–4), 4.4% (3.0–6.4), 5.8% (4.7–7.1) and not available. ; [Conclusion] Thrombectomy in routine clinical use registered in the SITS-ISTR showed safety and outcomes comparable to RCTs, and better functional outcomes and lower mortality than previous national registry studies. ; SITS (Safe Implementation of Treatment in Stroke) is financed directly and indirectly by grants from Karolinska Institutet, Stockholm County Council, the Swedish Heart-Lung Foundation, the Swedish Order of St. John, Friends of Karolinska Institutet and private donors, as well as from an unrestricted sponsorship from Boehringer Ingelheim. SITS has previously received grants from the European Union Framework 7, the European Union Public Health Authority, Ferrer International and EVER Pharma. SITS is currently conducting studies supported by Boehringer Ingelheim and Biogen, as well as in collaboration with Karolinska Institutet, supported by Stryker, Covidien and Phenox. N Ahmed is supported by grants provided by the Stockholm County Council and the Swedish Heart-Lung Foundation. S Holmin is supported by grants provided by the Söderberg Foundations, the Stockholm County Council, the Erling Persson Foundation, VINNOVA and HMT. Irene Escudero-Martínez has received a grant from 'Fundación Progreso y Salud, Junta de Andalucía' (grant EF-0437-2018). RM has been supported by the project no. LQ1605 from the National Program of Sustainability II (MEYS CR). RH has been supported by the grants no. DRO–UHHK 00179906 from the Ministry of Health of the Czech Republic and no. PROGRES Q40 from Charles University, Czech Republic. ; Peer reviewed

BMWFW ; FWF (Austria) ; FNRS ; FWO (Belgium) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; MES (Bulgaria) ; CERN ; CAS ; MOST ; NSFC (China) ; COLCIENCIAS (Colombia) ; MSES ; CSF (Croatia) ; RPF (Cyprus) ; MoER ; ERC IUT ; ERDF (Estonia) ; Academy of Finland ; MEC ; HIP (Finland) ; CEA ; CNRS/IN2P3 (France) ; BMBF ; DFG ; HGF (Germany) ; GSRT (Greece) ; OTKA ; NIH (Hungary) ; DAE ; DST (India) ; IPM (Iran) ; SFI (Ireland) ; INFN (Italy) ; NRF ; WCU (Republic of Korea) ; LAS (Lithuania) ; MOE ; UM (Malaysia) ; CINVESTAV ; CONACYT ; SEP ; UASLP-FAI (Mexico) ; MBIE (New Zealand) ; PAEC (Pakistan) ; MSHE ; NSC (Poland) ; FCT (Portugal) ; JINR (Dubna) ; MON ; RosAtom ; RAS ; RFBR (Russia) ; MESTD (Serbia) ; SEIDI ; CPAN (Spain) ; Swiss Funding Agencies (Switzerland) ; MST (Taipei) ; ThEPCenter ; IPST ; STAR ; NSTDA (Thailand) ; TUBITAK ; TAEK (Turkey) ; NASU ; SFFR (Ukraine) ; STFC (United Kingdom) ; DOE ; NSF (USA) ; Marie-Curie programme ; European Research Council ; EPLANET (European Union) ; Leventis Foundation ; A.P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT Belgium) ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Council of Science and Industrial Research, India ; HOMING PLUS programme of Foundation For Polish Science ; European Union ; Regional Development Fund ; Compagnia di San Paolo (Torino) ; Consorzio per la Fisica (Trieste) ; MIUR (Italy) ; EU-ESF ; Greek NSRF ; Qatar National Research Fund ; MIUR (Italy): 20108T4XTM ; Measurements of two-particle angular correlations between an identified strange hadron (K-S(0) or A/(A) over bar) and a charged particle, emitted in pPb collisions, are presented over a wide range in pseudorapidity and full azimuth. The data, corresponding to an integrated luminosity of approximately 35 nb(-1), were collected at a nucleon-nucleon center-of-mass energy (root s(NN)) of 5.02 TeV with the CMS detector at the LHC. The results are compared to semi-peripheral PbPb collision data at root s(NN) = 2.76 TeV, covering similar charged-particle multiplicities in the events. The observed azimuthal correlations at large relative pseudorapidity are used to extract the second-order (v(2)) and third-order (v(3)) anisotropy harmonics of K-S(0) and A/(A) over bar particles. These quantities are studied as a function of the charged-particle multiplicity in the event and the transverse momentum of the particles. For high-multiplicity pPb events, a clear particle species dependence of v(2) and v(3) is observed. For p(T) < 2 GeV, the v(2) and v(3) values of K-S(0) particles are larger than those of A/(A) over bar particles at the same p(T). This splitting effect between two particle species is found to be stronger in pPb than in PbPb collisions in the same multiplicity range. When divided by the number of constituent quarks and compared at the same transverse kinetic energy per quark, both v(2) and v(3) for K-S(0) particles are observed to be consistent with those for A/(A) over bar particles at the 10% level in pPb collisions. This consistency extends over a wide range of particle transverse kinetic energy and event multiplicities. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.

Austrian Federal Ministry of Science, Research and Economy ; Austrian Science Fund ; Belgian Fonds de la Recherche Scientifique ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Bulgarian Ministry of Education and Science ; CERN ; Chinese Academy of Sciences ; Ministry of Science and Technology ; National Natural Science Foundation of China ; Colombian Funding Agency (COLCIENCIAS) ; Croatian Ministry of Science, Education and Sport ; Croatian Science Foundation ; Research Promotion Foundation, Cyprus ; Ministry of Education and Research, Estonia ; Estonian Research Council, Estonia ; European Regional Development Fund, Estonia ; Academy of Finland, Finnish Ministry of Education and Culture ; Helsinki Institute of Physics ; Institut National de Physique Nucleaire et de Physique des Particules / CNRS, France ; Commissariat a l'Energie Atomique et aux Energies Alternatives / CEA, France ; Bundesministerium fur Bildung und Forschung, Germany ; Deutsche Forschungsgemeinschaft, Germany ; Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany ; General Secretariat for Research and Technology, Greece ; National Scientific Research Foundation, Hungary ; National Innovation Office, Hungary ; Department of Atomic Energy, India ; Department of Science and Technology, India ; Institute for Studies in Theoretical Physics and Mathematics, Iran ; Science Foundation, Ireland ; Istituto Nazionale di Fisica Nucleare, Italy ; Ministry of Science, ICT and Future Planning, Republic of Korea ; National Research Foundation (NRF), Republic of Korea ; Lithuanian Academy of Sciences ; Ministry of Education (Malaysia) ; Mexican Funding Agency (CINVESTAV) ; Mexican Funding Agency (CONACYT) ; Mexican Funding Agency (SEP) ; Mexican Funding Agency (UASLP-FAI) ; Ministry of Business, Innovation and Employment, New Zealand ; Pakistan Atomic Energy Commission ; Ministry of Science and Higher Education, Poland ; National Science Centre, Poland ; Fundacao para a Ciencia e a Tecnologia, Portugal ; JINR, Dubna ; Ministry of Education and Science of the Russian Federation ; Federal Agency of Atomic Energy of the Russian Federation ; Russian Academy of Sciences ; Russian Foundation for Basic Research ; Ministry of Education, Science and Technological Development of Serbia ; Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Spain ; Swiss Funding Agency (ETH Board) ; Swiss Funding Agency (ETH Zurich) ; Swiss Funding Agency (PSI) ; Swiss Funding Agency (SNF) ; Swiss Funding Agency (UniZH) ; Swiss Funding Agency (Canton Zurich) ; Swiss Funding Agency (SER) ; Ministry of Science and Technology, Taipei ; Special Task Force for Activating Research ; National Science and Technology Development Agency of Thailand ; Scientific and Technical Research Council of Turkey ; Turkish Atomic Energy Authority ; National Academy of Sciences of Ukraine, Ukraine ; State Fund for Fundamental Researches, Ukraine ; Science and Technology Facilities Council, UK ; US Department of Energy ; US National Science Foundation ; Marie-Curie program (European Union) ; European Research Council (European Union) ; EPLANET (European Union) ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Council of Science and Industrial Research, India ; HOMING PLUS program of the Foundation for Polish Science ; European Union, Regional Development Fund ; OPUS program of the National Science Center (Poland) ; Compagnia di San Paolo (Torino) ; Consorzio per la Fisica (Trieste) ; MIUR project (Italy) ; Thalis programme - EU-ESF ; Aristeia programme - EU-ESF ; National Priorities Research Program by Qatar National Research Fund ; Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) ; Welch Foundation ; Greek NSRF ; University of Malaya (Malaysia) ; Fonds voor Wetenschappelijk Onderzoek ; Programa Consolider-Ingenio, Spain ; Thailand Center of Excellence in Physics, the Institute for the Promotion of Teaching Science and Technology of Thailand ; Science and Technology Facilities Council ; Estonian Research Council, Estonia: IUT23-4 ; Estonian Research Council, Estonia: IUT23-6 ; MIUR project (Italy): 20108T4XTM ; Welch Foundation: C-1845 ; Science and Technology Facilities Council: ST/J50094X/1 ; Science and Technology Facilities Council: ST/J004901/1 ; Science and Technology Facilities Council: ST/H000925/1 ; Science and Technology Facilities Council: ST/I005912/1 GRIDPP ; Science and Technology Facilities Council: CMS ; Science and Technology Facilities Council: ST/K001531/1 ; Science and Technology Facilities Council: ST/K001329/1 ATLAS ; Science and Technology Facilities Council: ST/M005356/1 ; Science and Technology Facilities Council: ST/J005665/1 ; Science and Technology Facilities Council: GRIDPP ; Science and Technology Facilities Council: ST/L005603/1 ; Science and Technology Facilities Council: ST/K003844/1 ; Science and Technology Facilities Council: ST/I003622/1 ; Science and Technology Facilities Council: ST/M004775/1 GRIDPP ; Science and Technology Facilities Council: ST/M005356/1 GRIDPP ; Science and Technology Facilities Council: ST/K003542/1 GRIDPP ; Science and Technology Facilities Council: ST/I000305/1 ; Science and Technology Facilities Council: ST/L00609X/1 GRIDPP ; Science and Technology Facilities Council: ST/N000242/1 ; Science and Technology Facilities Council: ST/I005912/1 ; Science and Technology Facilities Council: ST/J004871/1 ; Science and Technology Facilities Council: ST/K003542/1 ; Science and Technology Facilities Council: ST/K001639/1 ; Science and Technology Facilities Council: ST/N001273/1 ; Science and Technology Facilities Council: ST/J005479/1 ; Science and Technology Facilities Council: ST/I003622/1 GRIDPP ; Science and Technology Facilities Council: ST/M004775/1 ; Science and Technology Facilities Council: ST/H000925/2 ; Science and Technology Facilities Council: ST/K003542/1 GRID PP ; Science and Technology Facilities Council: ST/L00609X/1 ; Science and Technology Facilities Council: ST/K001639/1 CMS Upgrades ; Science and Technology Facilities Council: PP/E000479/1 ; Science and Technology Facilities Council: PP/E002803/1 ; Science and Technology Facilities Council: ST/M002020/1 ; Science and Technology Facilities Council: ST/K003844/1 GRIDPP ; Science and Technology Facilities Council: ST/K003224/1 CMS Upgrades ; Science and Technology Facilities Council: ST/K001256/1 ; Science and Technology Facilities Council: ST/N000250/1 ; A search for pair production of first and second generation leptoquarks is performed in final states containing either two charged leptons and two jets, or one charged lepton, one neutrino and two jets, using proton-proton collision data at root s = 8 TeV. The data, corresponding to an integrated luminosity of 19.7 fb(-1), were recorded with the CMS detector at the LHC. First-generation scalar leptoquarks with masses less than 1010 (850) GeV are excluded for beta = 1.0 (0.5), where beta is the branching fraction of a leptoquark decaying to a charged lepton and a quark. Similarly, second-generation scalar leptoquarks with masses less than 1080 (760) GeV are excluded for beta = 1.0 (0.5). Mass limits are also set for vector leptoquark production scenarios with anomalous vector couplings, and for R-parity violating supersymmetric scenarios of top squark pair production resulting in similar final-state signatures. These are the most stringent limits placed on the masses of vector leptoquarks and RPV top squarks to date.