Comprende la parte de la ciudad de La Habana situada entre la calle de San Lázaro, campamento y castillo de El Príncipe y el cementerio de Colón ; Manuscrito coloreado a la acuarela, en rojo cuatro solares, probablemente con posterioridad a la elaboración del documentoplano ; Orientado con flecha ; Indica el nombre de algunas calles, las canteras localizadas en esta zona y los límites de diversas haciendas con mención del nombre de sus propietarios ; Señala la distribución que de todo este área se efectuó en manzanas y la división de éstas en solares, habiéndose establecido una numeración para diferenciar cada una de ellas y sus parcelas correspondientes, así como para las calles que se abrirán ; Figuran los límites de la 1a. y 2a. zona militar del castillo de El Príncipe y de la batería de Santa Clara
14 pags., 5 figs. ; Convolved images are often used to simulate the effect of ocular aberrations on image quality, where the retinal image is simulated by convolving the stimulus with the point spread function derived from the subject's aberrations. However, some studies have shown that convolved images are perceived far more degraded than the same image blurred with optical defocus. We hypothesized that the positive interactions between the monochromatic and chromatic aberrations in the eye are lost in the convolution process. To test this hypothesis, we evaluated optical and visual quality with natural optics and with convolved images (on-bench, computer simulations, and visual acuity [VA] in subjects) using a polychromatic adaptive optics system with monochromatic (555 nm) and polychromatic light (WL) illumination. The subject's aberrations were measured using a Hartmann Shack system and were used to convolve the visual stimuli, using Fourier optics. The convolved images were seen through corrected optics. VA with convolved stimuli was lower than VA through natural aberrations, particularly in WL (by 26% in WL). Our results suggest that the systematic decrease in visual performance with visual acuity and retinal image quality by simulation with convolved stimuli appears to be primarily associated with a lack of favorable interaction between chromatic and monochromatic aberrations in the eye. ; Supported by the Spanish Government (FIS2017-84753R, PID2020-115191RB-I00) to SM; Spanish Government Predoctoral (Grant FPU16/01944) to SA; H2020 Marie Sklodowska-Curie Actions (H2020 MSCA IF GF 2019 MYOMICRO 893557) to MV; European Research Council (ERC-2018-ADG SILKEYE 833106), NIH NIE P30EY 001319; and Unrestricted Funds Research to Prevent Blindness to SM. ; Peer reviewed
1 pag. -- This is a 2020 ARVO Annual Meeting abstract. ; Support COFUND Multiply: European Research Council (ERC) under European Union's Horizon 2020 research and innovation programme H2020-MSCA-COFUND-2015-FP-713694; Spanish government grant FIS2017-84753-R ; Peer reviewed
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019 ; Support European Project Multiply H-2020-MSCA-COFUND-2015 Ref. 713694, Spanish Government Grant FIS2017-84753-R, European Project Presbyopia ERC-2011-AdG Ref. 294099, European Project Imcustomeye H2020-ICT-2017 Ref. 779960, BES-2015-072197 ; Peer reviewed
15 pags., 9 figs., 1 tab. ; Visual simulators aim at evaluating vision with ophthalmic corrections prior to prescription or implantation of intraocular lenses (IOLs) in the patient's eye. In the present study, we present the design, implementation, and validation of a new IOL-in-cuvette channel in an Adaptive Optics visual simulator, which provides an alternative channel for pre-operative simulation of vision with IOLs. The IOL is projected on the pupil's plane of the subject by using a Rassow system. A second lens, the Rassow lens, compensates for an IOL of 20 D while other powers can be corrected with a Badal system within a 5 D range. The new channel was evaluated by through-focus (TF) optical quality in an artificial eye on bench, and by TF visual acuity in patients, with various IOL designs (monofocal, diffractive trifocal, and refractive extended depth of focus). ; Funding. Spanish Government (FIS2017-84753R) ; Peer reviewed
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019 ; Support European Research Council (ERC) under European Union's Horizon 2020 research and innovation programme H2020-MSCA-COFUND-2015-FP-713694, Spanish government grant FIS2014-56643-R, European Research Council under the European Union's Seventh Framework programme ERC-2011-AdG-294099, Patent P201130685, Patent US2016 62/329,392. ; Peer reviewed
13 pags., 7 figs. -- Open Access funded by Creative Commons Atribution Licence 4.0 ; Earlier studies have shown that the gradient index of refraction (GRIN) of the crystalline lens can be reconstructed in vitro using Optical Coherence Tomography (OCT) images. However, the methodology cannot be extended in vivo because it requires accurate measurements of the external geometry of the lens. Specifically, the posterior surface is measured by flipping the lens so that the posterior lens surface faces the OCT beam, a method that cannot be implemented in vivo. When the posterior surface is imaged through the lens in its natural position, it appears distorted by the unknown GRIN. In this study, we demonstrate a method to reconstruct both the GRIN and the posterior surface shape without the need to flip the lens by applying optimization routines using both on-axis and off-axis OCT images of cynomolgous monkey crystalline lenses, obtained by rotating the OCT delivery probe from -45 to +45 degrees in 5 degree steps. We found that the GRIN profile parameters can be reconstructed with precisions up to 0.009, 0.004, 1.7 and 1.1 (nucleus and surface refractive indices, and axial and meridional power law, respectively), the radius of curvature within 0.089 mm and the conic constant within 0.3. While the method was applied on isolated crystalline lenses, it paves the way to in vivo lens GRIN and posterior lens surface reconstruction. ; European Research Council (ERC) under European Union's Horizon 2020 research and innovation programme (H2020-MSCA COFUND-2015 FP-713694, MULTIPLY); Spanish government (FIS2014-56643-R, FIS2017-84753-R); European Research Council under the European Union's Seventh Framework programme (ERC-2011-AdG-2940); National Eye Institute (R01EY021834; F31EY021444); Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship (P30EY14801 Center Core Grant); the Florida Lions Eye Bank and Beauty of Sight Foundation; the Henri and Flore Lesieur Foundation.
8 pags., 6 figs. ; Purpose: The crystalline lens undergoes morphological and functional changes with age and may also play a role in eye emmetropisation. Both the geometry and the gradient index of refraction (GRIN) distribution contribute to the lens optical properties. We studied the lens GRIN in the guinea pig, a common animal model to study myopia. Methods: Lenses were extracted from guinea pigs (Cavia porcellus) at 18 days of age (n = 4, three monolaterally treated with negative lenses and one untreated) and 39 days of age (n = 4, all untreated). Treated eyes were myopic (−2.07 D on average) and untreated eyes hyperopic (+3.3 D), as revealed using streak retinoscopy in the live and cyclopeged animals. A custom 3D spectral domain optical coherence tomography (OCT) system (λ = 840 nm, Δλ = 50 nm) was used to image the enucleated crystalline lens at two orientations. Custom algorithms were used to estimate the lens shape and GRIN was modelled with four variables that were reconstructed using the OCT data and a minimisation algorithm. Ray tracing was used to calculate the optical power and spherical aberration assuming a homogeneous refractive index or the estimated GRIN. Results: Guinea pig lenses exhibited nearly parabolic GRIN profiles. When comparing the two age groups (18- and 39 day-old) there was a significant increase in the central thickness (from 3.61 to 3.74 mm), and in the refractive index of the surface (from 1.362 to 1.366) and the nucleus (from 1.443 to 1.454). The presence of GRIN shifted the spherical aberration (−4.1 µm on average) of the lens towards negative values. Conclusions: The guinea pig lens exhibits a GRIN profile with surface and nucleus refractive indices that increase slightly during the first days of life. GRIN plays a major role in the lens optical properties and should be incorporated into computational guinea pig eye models to study emmetropisation, myopia development and ageing. ; This work was supported by European Research Council (ERC) Grant Agreement ERC-2011-AdC- 294099; ERC under the European Union's Horizon 2020 research and innovation programme (H2020-MSCA COFUND-2015 FP-713694, MULTIPLY) and under grant agreement No 779960, IMCUSTOMEYE and No 675137 (MyFUun MSCA ITN); Spanish Government Grant FIS2017-84753-R; Hunter Medical Research Institute G1400967 and the University of Newcastle (FVG 1031537 and SSP).
ARVO Annual Meeting Abstract (2019) ; Support European Research Council ERC-2011-AdG 294099; Spanish Government FIS2014-56643-R, FIS2017-84753-R; H-2020-MSCA-COFUND-2015 713694 ; Peer reviewed
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019. ; Support Spanish Government Grant FIS2014-56643-R; Spanish Government Grant FIS2017-84753-R; European Project Presbyopia ERC-2011-AdG Ref. 294099; National Eye Institute Grants 2R01EY021834, P30EY14801 (Center Grant); the Hyderabad Eye Research Foundation; Florida Lions Eye Bank and the Beauty of Sight Foundation; Drs KR Olsen and ME Hildebrandt; Drs R Urs and A Furtado; the Henri and Flore Lesieur Foundation (JMP); an unrestricted grant from Research to Prevent Blindness. ; Peer reviewed