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When a synthetic chemical is released into the environment it may be degraded by abiotic and biotic processes. These degradation processes usually involve a cascade of reactions resulting in the formation of a number of transformation products. While we usually know a great deal about the environmental properties, fate and effects of parent synthetic chemicals, our understanding of the impacts of transformation products is much less developed. As such, this volume brings together chapters from leading researchers in the field of transformation products in the environment and describes how thes

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science-policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science-policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health. ; The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science-policy interface body. Major challenges for ...

AbstractThe chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health.

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science-policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science-policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health. ; Open Access funding enabled and organized by Projekt DEAL. Not applicable. ; Peer reviewed

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health.

Background: Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. Objective: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. Data sources: To better understand and manage the risks of PPCPs in the environment, we used the "key question" approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. Data synthesis: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, d) effects characterization, e) risk and relative risk, f) antibiotic resistance, and g) risk management. Conclusions: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic. ; Centro de Investigaciones del Medioambiente

Background: Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. Objective: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. Data sources: To better understand and manage the risks of PPCPs in the environment, we used the "key question" approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. Data synthesis: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, d) effects characterization, e) risk and relative risk, f) antibiotic resistance, and g) risk management. Conclusions: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic. ; Fil: Boxall, Alistair B. A. University of York; Reino Unido ; Fil: Rudd, Murray A. University of York; Reino Unido ; Fil: Brooks, Bryan W. Baylor University; Estados Unidos ; Fil: Caldwell, Daniel J. Johnson & Johnson; Estados Unidos ; Fil: Choi, Kyungho. Seoul National University; Corea del Sur ; Fil: Hickmann, Silke. Umweltbundesamt; Alemania ; Fil: Innes, Elizabeth. Health Canada; Canadá ; Fil: Ostapyk, Kim. Health Canada; Canadá ; Fil: Staveley, Jane P. Exponent; Estados Unidos ; Fil: Verslycke, Tim. Gradient; Estados Unidos ; Fil: Ankley, Gerald T. United States Environmental Protection Agency; Estados Unidos ; Fil: Beazley, Karen F. Dalhousie University Halifax; Canadá ; Fil: Belanger, Scott E. Procter And Gamble; Estados Unidos ; Fil: Berninger, Jason P. Baylor University; Estados Unidos ; Fil: Carriquiriborde, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina ; Fil: Coors, Anja. Ect Oekotoxikologie Gmbh; Alemania ; Fil: DeLeo, Paul C. American Cleaning Institute; Estados Unidos ; Fil: Dyer, Scott D. Procter And Gamble; Estados Unidos ; Fil: Ericson, Jon F. Pfizer Inc.; Estados Unidos ; Fil: Gagné, François. Environment Canada; Canadá ; Fil: Giesy, John P. University of Saskatchewan; Canadá ; Fil: Gouin, Todd. Unilever; Reino Unido ; Fil: Hallstrom, Lars. University of Alberta; Canadá ; Fil: Karlsson, Maja V. University of York; Reino Unido ; Fil: Joakim Larsson, D.G. University of Göteborg; Alemania ; Fil: Lazorchak, James M. United States Environmental Protection Agency; Estados Unidos ; Fil: Mastrocco, Frank. Pfizer Inc.; Estados Unidos ; Fil: McLaughlin, Alison. Health Canada; Canadá ; Fil: McMaster, Mark E. Environment Canada; Canadá ; Fil: Meyerhoff, Roger D. Eli Lilly And Company; Estados Unidos ; Fil: Moore, Roberta. Health Canada; Canadá ; Fil: Parrott, Joanne L. Environment Canada; Canadá ; Fil: Snape, Jason R. AstraZeneca UK Ltd.; Reino Unido ; Fil: Murray-Smith, Richard. AstraZeneca UK Ltd.; Reino Unido ; Fil: Servos, Mark R. University of Waterloo; Canadá ; Fil: Sibley, Paul K. University of Guelph; Canadá ; Fil: Straub, Jürg Oliver. F. Hoffmann-La Roche Ltd.; Suiza ; Fil: Szabo, Nora D. University of Ottawa; Canadá ; Fil: Topp, Edward. Agriculture Et Agroalimentaire Canada; Canadá ; Fil: Tetreault, Gerald R. University of Waterloo; Canadá ; Fil: Trudeau, Vance L. University of Ottawa; Canadá ; Fil: Van Der Kraak, Glen. University of Guelph; Canadá