Suchergebnisse

In this work, we assess the role of a specific type of organized crime in influencing choices on where living within the city territory, and consequently, volatility in house prices. More specifically, we test how organized crime killing may influence house pricing behaviors. Firstly, we show evidences about how organized crime is associated with higher inequality of housing prices for Italian cities in 2011. Then, by collecting and geo referencing data on the city of Naples for the period 2002-2016, we test for the direct influence of homicides on the relevant territory, as on the neighboring districts. Results show a negative and significant impact of killing on the house prices either for sales or for rents and a positive effect in neighboring district, driving increases in within-city inequality.

In this chapter we contribute to the recent literature (e.g., Istat, 2010, Acciari et al., 2016, Guell et al., 2017) that provides evidence that inequality is high and social mobility is low in the Italian regions and prov-inces where organized crime is widespread such as those of Southern Italy. We complement this line of work in two respects. First, using a novel pan-el dataset at the regional level for the period 1985-2014 we investigate the relationship between inequality and organized crime at the regional level, exploiting both time and cross-sectional variation. Second, we assess the role of social mobility in organized crime. Our main finding is that higher inequality leads to higher organized crime development. The results are robust for different organized crime measures and inequality indices. For all measures the ratio of 90th quintile over the 10th in the distribution is a strong predictor of organized crime, even if we control for other covariates that capture economic development, education, etc. We also find that consumption inequality performs better that income inequality as the relevant inequality measure. Finally, we conduct a provincial level analysis to study the effect of socio-economic mobility on organized crime. We consider three alternative measures of social mobility. We find that lower socio-economic mobility displays a robust association with organized crime development

Chromatin modifiers play a crucial role in maintaining cell identity through modulation of gene expression patterns. Their deregulation can have profound effects on cell fate and functions. Among epigenetic regulators, the MECP2 protein is particularly attractive. Mutations in the Mecp2 gene are responsible for more than 90% of cases of Rett syndrome (RTT), a progressive neurodevelopmental disorder. As a chromatin modulator, MECP2 can have a key role in the government of stem cell biology. Previously, we showed that deregulated MECP2 expression triggers senescence in mesenchymal stromal cells (MSCs) from (RTT) patients. Over the last few decades, it has emerged that senescent cells show alterations in the metabolic state. Metabolic changes related to stem cell senescence are particularly detrimental, since they contribute to the exhaustion of stem cell compartments, which in turn determine the falling in tissue renewal and functionality. Herein, we dissect the role of impaired MECP2 function in triggering senescence along with other senescence-related aspects, such as metabolism, in MSCs from a mouse model of RTT. We found that MECP2 deficiencies lead to senescence and impaired mitochondrial energy production. Our results support the idea that an alteration in mitochondria metabolic functions could play an important role in the pathogenesis of RTT.