Suchergebnisse

There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m6A modifications play important roles in regulating viral replication by interacting with the cellular m6A machinery. In this review, we will exhaustively detail the current knowledge on m6A modification, with an emphasis on its function in virus biology. ; This work was supported by the Spanish Ministry of Science and Innovation through grants PID2019-106959RB-I00/AEI/10.13039/501100011033, an institutional "Maria de Maeztu" Programme for Units of Excellence in R&D (CEX2018-000792-M), by the 2017 SGR 909 grant from the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement of the Generalitat de Catalunya and a Beatriu Pinós postdoctoral fellowship awarded to Belinda Baquero-Perez which is funded by the Secretary of Universities and Research (Government of Catalonia) and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie grant agreement No 801370. All figures in this review were drawn using BioRender.