Suchergebnisse

"Hippo signaling has been recognized as a newly identified tumor suppressor signaling pathway that can regulate cellular processes including regeneration, cell death, differentiation, and development. Its dysregulation through overexpression of YAP (Yes-associated protein) and TAZ (PDZ-binding motif) as two main oncogenic factors of the Hippo pathway has a crucial role in several cancers. Because of the limited prognosis and therapeutic targets, further understanding of molecular pathways involved in tumorigenesis is one of the interesting issues in studies. Here, we demonstrated that some viruses, through dysregulation of the Hippo signaling pathway can be implicated in transformation, metastasis, and chemotherapeutic drug resistance in virus-related cancer and also help processes involved in the pathogenesis of viral infection such as persistence "

"Introduction: One of the methods utilized to treat infertility is the use of frozen embryos. This technique is particularly employed in patients with ovarian hyperstimulation syndrome (OHSS), which leads to heightened blood estrogen levels. The purpose of this study was to compare the percentage of pregnancy and abortion between patients who used the frozen embryo method due to OHSS and others who practiced the same method for other reasons. Materials and Methods: This retrospective, cohort study was conducted on a total of 338 patients who visited in vitro fertilization (IVF) section of Kowsar Hospital of Urmia-Iran to employ the frozen embryo method (May 2013 to December 2015). The patients were classified into two groups, i.e. the OHSS group (N=150) and the non-OHSS group (N=188). Data were obtained and examined by evaluating the files in a questionnaire. Results: The two groups did not differ significantly with regard to their mean age (p = 0.57). There was also no statistically significant difference between the OHSS and non-OHSS groups regarding the quality of frozen embryo transferred (P = 0.17). Also, there was also no statistically significant difference between the two groups in terms of their pregnancy rate (OHSS = 30.0% vs. non-OHSS = 25.0%) and miscarriage rate (OHSS = 31.11% vs. non-OHSS = 24.44%) (p = 0.32 and p = 0.31, respectively). Conclusion: Ovum exposure to high estrogen during ovulation stimulation does not affect embryo implantation and miscarriage in patients with OHSS."

Collaboration is essential to manage complex real world problems. We used phenomenologic methods to elaborate a description of collaboration between two departments at an academic medical center who considered their relationship to represent a model of effective collaboration. Key collaborative structures included a shared vision and commitment by leaders, rigorous quality improvement, clear delineation of roles with built-in flexibility, ongoing commitment to formal and informal communication channels and conflict resolution, relationship development grounded in respect and responsiveness, and shared training in a supportive learning environment with legitimate participation fostering skill development. This study reveals the complexity and resources required for collaboration which both explains why collaboration is not as easy to achieve and identifies processes that foster collaboration.

Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.

"The central lip lift surgery with a new suture technique called; continuous locking suture in three cases is reported in this article. In this novel method, we used a 5.0 chromic suture by applying a 30-degree angle of the entrance to the skin semi-deeply. We start suturing at the middle of the wound,3-4 mm from the edges of the skin. The needle should be way out at the exact point of entrance, and this process is repeated to reach out to the two sides of the wound. More than 90% of patients (in more than 100 cases) were satisfied with the cosmetic results. Moreover, 90% of cases did not demonstrate any scar after three months without laser or reconstructive ointments. We evaluate many patients who undergo central lip lift surgery with this novel technique, and the scar problem was resolved in more than 90 % of cases with no supportive treatment."

Introduction: Military job and work environment in a way that creates a lot of stress for person. Attention to the mental health of military forces is an obvious case. Aim of this study is comparison of mental health staffs and soldiers in one of the Army units Ahvaz Iran. Methods: This study was conducted as a cross-sectional study. The study population consisted of all personnel staff and soldiers of one of the Army units in Ahvaz. Sample size was 250 (125 staff and 125 soldiers). In this study for gathering of information was used from general health questionnaire (GHQ-28). Independent t-test for the quantitative variables and chi-square test was used to compare qualitative variables. For analyze statistical data was used of statistical software SPSS version 20. Results: The means score of mental health was 40.27 for staff and 36.3 for soldiers that both were unhealthy level. Soldiers had higher levels of mental health (P-value = 0.004). This study showed that the majority of staff (97.6 percent) and soldiers (96.4 percent) had poor mental health condition. Majority of staff (59.8 percent) and majority of soldiers (70.7 percent) had mild level of psychological problems. Conclusion: Most military personnel in this study had unhealthy mental health conditions and the level of mental health problems were mild. Soldiers had higher levels of mental health. More attention has necessary for mental health in military environment, in particular psychological environment of constant military staff. Key Words: Mental health, Military Personnel , GHQ-28