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Situated at the intersection of the cultural study of pharmaceuticals and the cultural study of law and using Trantor's (2011) critique of 'the law and technology enterprise' as a point of departure, this paper examines the pill as a techno-legal device. Just as pills contain an active pharmacological ingredient so too do they contain active legal ingredients. Where the molecular composition of pills are designed by chemists their legal-semic aspects are designed by lawyers. These are collaborative projects. Where the former are interested in the effects of molecules at bio-sites, the latter are concerned with the effects of legal signifiers in relation to each other as interpreted in a range of hermeneutic sites through cultural practices of reading and meta-reading. These meanings are built into the molecule itself thus resulting in the fabrication of legal molecules.

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Photonics, copyright © 2017 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/acsphotonics.7b00680 ; We present an overview of the general concepts of polaritonic chemistry with organic molecules, i.e., the manipulation of chemical structure that can be achieved through strong coupling between confined light modes and organic molecules. Strong coupling and the associated formation of polaritons, hybrid light-matter excitations, lead to energy shifts in such systems that can amount to a large fraction of the uncoupled transition energy. This has recently been shown to significantly alter the chemical structure of the coupled molecules, which opens the possibility to manipulate and control reactions. We discuss the current state of theory for describing these changes and present several applications, with a particular focus on the collective effects observed when many molecules are involved in strong coupling ; This work has been funded by the European Research Council under grant agreements ERC-2011-AdG-290981 and ERC-2016-STG- 714870, by the European Union Seventh Frame-work Programme under grant agreement FP7-PEOPLE-2013-CIG-618229, and the Spanish MINECO under contractMAT2014-53432-C5-5-R and the"María de Maeztu"programfor Units of Excellence in R&D (MDM-2014-0377).

Trapping light with noble metal nanostructures overcomes the diffraction limit and can confine light to volumes typically on the order of 30 cubic nanometers. We found that individual atomic features inside the gap of a plasmonic nanoassembly can localize light to volumes well below 1 cubic nanometer ("picocavities"), enabling optical experiments on the atomic scale. These atomic features are dynamically formed and disassembled by laser irradiation. Although unstable at room temperature, picocavities can be stabilized at cryogenic temperatures, allowing single atomic cavities to be probed for many minutes. Unlike traditional optomechanical resonators, such extreme optical confinement yields a factor of 106 enhancement of optomechanical coupling between the picocavity field and vibrations of individual molecular bonds. This work sets the basis for developing nanoscale nonlinear quantum optics on the single-molecule level. ; We acknowledge financial support from EPSRC grants EP/G060649/1 and EP/L027151/1, and ERC grant LINASS 320503. MKS, YZ, AD, RE, and JA acknowledge financial support from Project FIS2013- 41184-P from MINECO and IT756-13 from the Basque Government consolidated groups. FB acknowledges support from the Winton Programme for the Physics of Sustainability. RC acknowledges support from the Dr. Manmohan Singh scholarship from St. John's College. CC thanks NPL for support. RE acknowledges support from the Fellows Gipuzkoa Program of the Gipuzkoako Foru Aldundia via FEDER funds of the European Union "Una manera de hacer Europa". ; Peer reviewed