Suchergebnisse

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a growing public health challenge closely associated with metabolic syndrome. It manifests itself from simple steatosis to steatohepatitis (MASH), fibrosis and cirrhosis. The revised nomenclature better reflects the role of metabolic disorders. The pathophysiology is complex, characterised by metabolic risk factors, lipotoxicity and inflammatory processes. Advances in research emphasise the importance of mitochondrial functions and immune responses. In diagnostics, non-invasive methods have priority in order to minimise risks and costs. Imaging techniques and serum-based scores support the assessment of fibrosis stages. Treatment focusses on lifestyle changes, especially weight reduction and physical activity. Pharmacological interventions are still under investigation, with promising approaches in clinical trials. The high prevalence of MASLD in diabetic patients and its association with severe complications emphasise the urgency of effective diagnostic and treatment strategies. Future research and innovative therapies are crucial to improve the prognosis for affected individuals and reduce the burden of disease.

Statistiken mit detaillierten Angaben zur Binnenwanderung, der Zusammensetzung der Arbeitskräfte nach Alter, Geschlecht, Ausbildung, Beruf, Wohnort und Wirtschaftssektor; Angaben zur Arbeitslosenstatistik (Dauer der Arbeitslosigkeit; früherer Beruf, Ausbildungsniveau, Wirtschaftssektor, Geschlecht); im Anschluß an die 50seitige Deskription der Arbeitskräftesituation folgen die Statistiken sowohl in arabischer als auch englischer Sprache. (DÜI-Faa)

Purpose
The challenges of transferring the theoretical requirements of an effective multi-agency partnership into everyday practices are often overlooked, particularly within safeguarding practices. Therefore, the purpose of this paper is to explore practitioner perspectives of working within a multi-agency safeguarding hub (MASH) and those factors that encourage or hinder a multi-agency approach to safeguarding vulnerable individuals.


Design/methodology/approach
Semi-structured interviews with 23 practitioners from one MASH location in the North of England were conducted, with a thematic analysis being used to analyse findings.


Findings
The interviews with practitioners illustrated the complexity of establishing a multi-agency approach to safeguarding. It was inferred that whilst information sharing and trust between agencies had improved, the absence of a common governance structure, unified management system, formalisation of practices and procedures and shared pool of resources limited the degree to which MASH could be considered a multi-agency approach to safeguarding.


Practical implications
Establishing a multi-agency approach to safeguarding is complex and does not occur automatically. Rather, the transition to collaborative practices needs to be planned, with agreed practices and processes implemented from the beginning and reviewed regularly.


Originality/value
Few studies have investigated the implementation of MASH into safeguarding practices, with this paper providing a unique insight into practitioner opinions regarding the transition to multi-agency practices. Whilst there is a focus on MASH, the challenges to arise from the research may be reflective of other multi-agency partnerships, providing a foundation for best practice to emerge.

This 2nd part of the review on the diagnosis and care of patients with of patients with metabolically associated steatohepatitis (MASH) addresses the challenges the challenges and recommendations in consideration of the current S2k guidelines. The diagnostic algorithm focusses on on a screening procedure for the early detection of MASH, with general practitioners are key players. In the event of elevated liver values or an abnormal Fatty Liver index, further examinations and, if necessary, referral to a specialist are are planned. Particularly for risk groups such as people with type 2 diabetes, obesity obesity or metabolic syndrome, early identification is essential, to be able to take preventive action. Comprehensive metabolic diagnostics is a is a prerequisite for preventing the progression of the disease. However, the care situation in the diagnosis of MASH is characterised by a number of characterised by a number of limitations, including the limited use of the of the screening algorithm and the challenges involved in making a definitive diagnosis by means of liver biopsy. The discrepancy between the diagnosed number of MASH cases diagnosed and the presumed prevalence indicates a significant significant number of undiagnosed cases, which ultimately also leads to therapeutic deficit

The term 'mash-up' refers to websites that weave data from different sources into new Web services. The key to a successful Web service is to gather and use large datasets and harness the scale of the Internet through what is known as network effects. This means that data sources are just as important as the software that 'mashes' them, and one of the most profound pieces of data that a user has at any one time is his or her location. In the past this was a somewhat fuzzy concept, perhaps as vague as a verbal reference to being in a particular shop or café or an actual street address. Recent events, however, have changed this. In the 1990s, President Bill Clinton's policy decision to open up military GPS satellite technology for 'dual-use' (military and civilian) resulted in a whole new generation of location-aware devices. Around the same time, cartography and GIScience were also undergoing dramatic, Internet-induced changes. Traditional, resource intensive processes and established organizations, in both the public and private sectors, were being challenged by new, lightweight methods. The upshot has been that map making, geospatial analysis and related activities are undergoing a process of profound change. New players have entered established markets and disrupted routes to knowledge and, as we have already seen with Web 2.0, newly empowered amateurs are part of these processes. Volunteers are quite literally grabbing a GPS unit and hitting the streets of their local town to help create crowdsourced datasets that are uploaded to both open source and proprietary databases. The upshot is an evolving landscape which Tim O'Reilly, proponent of Web 2.0 and always ready with a handy moniker, has labelled Where 2.0. Others prefer the GeoWeb, Spatial Data Infrastructure, Location Infrastructure, or perhaps just location based services. Whatever one might call it, there are a number of reasons why its development should be of interest to those in higher and further education. Firstly, since a person's location is such a profound unit of information and of such value to, for example, the process of targeting advertising, there has been considerable investment in Web 2.0-style services that make use of it. Understanding these developments may provide useful insights for how other forms of data might be used. Secondly, education, particularly research, is beginning to realize the huge potential of the data mash-up concept. As Government, too, begins to get involved, it is likely that education will be expected to take advantage of, and indeed come to relish, the new opportunities for working with data. This TechWatch report describes the context for the changes that are taking place and explains why the education community needs to understand the issues around how to open up data, how to create mash-ups that do not compromise accuracy and quality and how to deal with issues such as privacy and working with commercial and non-profit third parties. It also shows how data mash-ups in education and research are part of an emerging, richer information environment with greater integration of mobile applications, sensor platforms, e-science, mixed reality, and semantic, machine-computable data and speculates on how this is likely to develop in the future.

This book examines the history of sexual harassment in America's public places, such as on the streets and on public transit vehicles, in the period 1880 to 1930. Such behavior was referred to then as mashing with the harasser most commonly being called a masher. It began around 1880 as a response to the women's movement as females in America increased their efforts to gain more freedom of movement and greater independence. Women going out and about on their own, or only with other women, threatened male dominance and control of society. One response by men was to turn to the sexual harassment

Operation Iraqi Freedom was perhaps the last military campaign that will ever utilize the services of a mobile Army surgical hospital (MASH). The Army has now essentially replaced the MASH with combat surgical hospitals (CSH) and forward surgical teams (FST). MASH units were designed as mobile, flexible, forward-deployed military hospitals, providing care for the wounded near the frontlines of the battlefield. These hospitals not only saved thousands of lives during war but also greatly influenced the delivery of trauma and critical care in civilian hospitals. The MASH was made popular by the television series of the 1970s, depicting the 4077th during the Korean War. Although a comical series, these television episodes provided viewers with a glimpse of life in a MASH during time of war. This article chronicles the history of the MASH from its inception during World War II to recent experiences in Operation Iraqi Freedom.