Suchergebnisse

Full list of authors: Amati, L.; O'Brien, P. T.; Götz, D.; Bozzo, E.; Santangelo, A.; Tanvir, N. ; Frontera, F.; Mereghetti, S.; Osborne, J. P.; Blain, A.; Basa, S.; Branchesi, M.; Burderi, L.; Caballero-García, M.; Castro-Tirado, A. J.; Christensen, L.; Ciolfi, R.; De Rosa, A.; Doroshenko, V.; Ferrara, A.; Ghirlanda, G.; Hanlon, L.; Heddermann, P.; Hutchinson, I.; Labanti, C.; Le Floch, E.; Lerman, H.; Paltani, S.; Reglero, V.; Rezzolla, L.; Rosati, P.; Salvaterra, R.; Stratta, G.; Tenzer, C.; Theseus Consortium.--This Open Access article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. ; THESEUS, one of the two space mission concepts being studied by ESA as candidates for next M5 mission within its Comsic Vision programme, aims at fully exploiting Gamma-Ray Bursts (GRB) to solve key questions about the early Universe, as well as becoming a cornerstone of multi-messenger and time-domain astrophysics. By investigating the first billion years of the Universe through high-redshift GRBs, THESEUS will shed light on the main open issues in modern cosmology, such as the population of primordial low mass and luminosity galaxies, sources and evolution of cosmic re-ionization, SFR and metallicity evolution up to the "cosmic dawn" and across Pop-III stars. At the same time, the mission will provide a substantial advancement of multi-messenger and time-domain astrophysics by enabling the identification, accurate localisation and study of electromagnetic counterparts to sources of gravitational waves and neutrinos, which will be routinely detected in the late '20s and early '30s by the second and third generation Gravitational Wave (GW) interferometers and future neutrino detectors, as well as of all kinds of GRBs and most classes of other X/gamma-ray transient sources. Under all these respects, THESEUS will provide great synergies with future large observing facilities in the multi-messenger domain. A Guest Observer programme, comprising Target of Opportunity (ToO) observations, will expand the science return of the mission, to include, e.g., solar system minor bodies, exoplanets, and AGN. © 2021, The Author(s). ; The authors, on behalf of the entire THESEUS consortium, are grateful to the ESA-appointed THESEUS Study Scientist Matteo Guainazzi, as well as the entire ESA Study Team for all their work and support across the mission assessment phase (2018-2021). Authors from the Italian National Institute of Astrophysics (INAF) are grateful for the support received through the agreement ASI-INAF n. 2n. 2018-29-HH.0. Open access funding provided by Istituto Nazionale di Astrofisica within the CRUI-CARE Agreement. ; With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709. ; Peer reviewed

The scope of this paper is to discuss two important questions relevant for TeV γ-ray astronomy; the pursuit to reveal the origin of cosmic rays in our galaxy, and the opacity of the universe in γ-rays. The origin of cosmic rays stipulated the field of TeV astronomy in the first place, and led to the development of the atmospheric Cherenkov technique; significant progress has been made in the last decade through the detection of several supernova remnants, the primary suspects for harboring the acceleration sites of cosmic rays. TeV γ-rays propagate mostly unhindered through the galactic plane, making them excellent probes of processes in SNRs and other galactic sources. Key results related to the SNR origin of cosmic rays are discussed. TeV γ-ray spectra from extragalactic sources experience significant absorption when traversing cosmological distances. The opacity of the universe to γ-rays above 10 GeV progressively increases with energy and redshift; the reason lies in their pair production with ambient soft photons from the extragalactic background light (EBL). While this limits the γ-ray horizon, it offers the opportunity to gain information about cosmology, i.e. the EBL intensity, physical conditions in intergalactic space, and potentially new interaction processes. Results and implications pertaining to the EBL are given.

Successfully launched in June 2008, the Fermi Gamma-ray Space Telescope, formerly named GLAST, has been observing the high-energy gamma-ray sky with unprecedented sensitivity in<br />the 20MeV ÷ 300 GeV energy range and electrons + positrons in the 7 GeV ÷ 1TeV range, opening a new observational window on a wide variety of astrophysical objects.

Intro -- Contents -- Foreword by Raymond E. Foster -- Acknowledgments -- 1 The Birth of High-Tech Police Work -- 2 Training -- 3 Vehicles -- 4 Dispatch and Communications -- 5 Uniformed Officers -- 6 Detectives -- 7 SWAT and Bomb Squad -- 8 Lie Detection -- 9 Automated Fingerprint Identification -- 10 DNA Analysis -- 11 Computers -- 12 Some Thoughts about Technology -- Notes -- Bibliography -- Index.

Radio protective effects of metformin and its ability to alter the spontaneous and induced genotoxic and cytotoxic levels effects on human peripheral blood lymphocytes were investigated in this study. Metformin, a hypoglycemic oral drug, is a biguanide derived from Galega officinalis that is widely utilized in controlling type 2 diabetes mellitus. Whole blood samples from 10 healthy donors (5 males and 5 females) were exposed to two doses of gamma-rays (1 and 2 Gray). Lymphocytes in cultures were treated with metformin (10 and 50µM) before gamma-irradiation. Cytokinesis-block micronucleus test was used to evaluate the protective effects of metformin on radiation induced genomic damage, cytostasis and cytotoxicity, via scoring micronuclei and nucleoplasmic bridges in once divided binucleated cells as well as counting nuclear division index. The results of the current study revealed that the increase in micronuclei and nucleoplasmic bridges rate is associated with the decrease of nuclear division index in human lymphocytes exposed to gamma radiation in a dose dependent manner. Metformin effectively decreased the rate of spontaneous micronuclei and nucleoplasmic bridges paralleled with the control as well as increased nuclear division index. Moreover, treatment of whole blood samples with metformin (10 and 50 µM), 2 h preceding to irradiation, remarkably reduced rate of micronuclei and nucleoplasmic bridges accompanied with an increase in nuclear division index rate. The results introduced metformin to be an effective radio protector against DNA damage induced by gamma radiation in human lymphocytes and that it can be used to develop radio protective materials for protection cells of cancer patients from the genomic damage prompted via radiotherapy.

WOS: 000314826000009 ; The response of AGATA segmented HPGe detectors to gamma rays in the energy range 2-15 MeV was measured. The 15.1 MeV gamma rays were produced using the reaction d(B-11,n gamma)C-12 at E-beam=19.1 MeV, while gamma rays between 2 and 9 MeV were produced using an Am-Be-Fe radioactive source. The energy resolution and linearity were studied and the energy-to-pulse-height conversion resulted to be linear within 0.05%.Experimental interaction multiplicity distributions are discussed and compared with the results of Geant4 simulations. It is shown that the application of gamma-ray tracking allows a suppression of background radiation caused by n-capture in Ge nuclei. Finally the Doppler correction for the 15.1 MeV gamma line, performed using the position information extracted with Pulse-shape analysis is discussed. (C) 2012 Elsevier B.V. All rights reserved. ; European Union [262010-ENSAR]; MINECO Spain [AIC-D-2011-0746, FPA2011-29854]; Generalitat Valenciana, Spain [PROME-TEO/2010/101]; German BMBF [06K-167, 06KY205I] ; This research has received funding from the European Union Seventh Framework Program FP7/2007-2013 under grant Agreement no. 262010-ENSAR. A.G. activity has been supported by the MINECO Spain, under grants AIC-D-2011-0746, FPA2011-29854 and by and Generalitat Valenciana, Spain, under grant PROME-TEO/2010/101. We acknowledge the support by the German BMBF under Grants 06K-167 and 06KY205I.