Suchergebnisse

Catecholamine-triggered β-adrenoceptor (β-AR) signaling is essential for the correct functioning of the heart. Although both β1 - and β2 -AR subtypes are expressed in cardiomyocytes, drugs selectively targeting β1 -AR have proven this receptor as the main target for the therapeutic effects of beta blockers in the heart. Here, we report a new strategy for the light-control of β1 -AR activation by means of photoswitchable drugs with a high level of β1 -/β2 -AR selectivity. All reported molecules allow for an efficient real-time optical control of receptor function in vitro. Moreover, using confocal microscopy we demonstrate that the binding of our best hit, pAzo-2, can be reversibly photocontrolled. Strikingly, pAzo-2 also enables a dynamic cardiac rhythm management on living zebrafish larvae using light, thus highlighting the therapeutic and research potential of the developed photoswitches. Overall, this work provides the first proof of precise control of the therapeutic target β1 -AR in native environments using light. ; We thank Ignacio Pérez (IQAC-CSIC, Barcelona), Yolanda Pérez (IQAC-CSIC, Barcelona), Lourdes Muñoz (SimChem, IQAC-CSIC, Barcelona) and Carme Serra (SimChem, IQAC-CSIC, Barcelona) for technical support. We thank Diana Baxter (Institute for Research in Biomedicine, IRB, Barcelona) for her thorough revision of the language of this manuscript. We thank Dr. Kees Jalink (The Netherlands Cancer Institute, Amsterdam, the Netherlands) for providing the plasmids encoding for the Epac-SH188 biosensor. We thank the University of Vic-Central University of Catalonia (UVic-UCC) and Dr. Marta Otero for the material assignment which helped in some biological assays. We thank Nikos Hatzakis for access to the Olympus IX81 confocal microscope (UCPH, DK). This work was supported by ERDF-FEDER European Fund and Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación (projects CTQ2017-89222-R and PID2020-120499RB-I00) and by the Catalan government (2017 SGR 1604) to A.L. X.R. research was financed by the ...

PLEASE NOTE: This item has been superceded by a new version. Electromagnetics Volume 1 (Aug. 2018), which is freely available electronically. Abstract: Electromagnetics Volume 1 (BETA) (CC BY-SA 4.0) by Steven W. Ellingson is a 224-page, peer-reviewed, open educational resource intended to serve as a primary textbook for a one-semester first course in undergraduate engineering electromagnetics, and includes: electric and magnetic fields; electromagnetic properties of materials; electromagnetic waves; and devices that operate according to associated electromagnetic principles including resistors, capacitors, inductors, transformers, generators, and transmission lines. This book employs the "transmission lines first" approach, in which transmission lines are introduced using a lumped-element equivalent circuit model for a differential length of transmission line, leading to one-dimensional wave equations for voltage and current. This is intended for electrical engineering students in the third year of a bachelor of science degree program. Print copies of this book are available on Amazon.com (ISBN:978-0997920123). About this Beta version: The BETA version of Volume 1 is being field tested in a Spring 2018 course. It will be updated and re-released at this site in VTechWorks in Summer 2018. The following will also be added: index (within the book); problem sets, solution manual, and LaTeX source code (in VTechWorks). Use, sharing, contributions to, and customization of this book or portions of this book or figures are an inherent part of the intent of the way this book has been published. Please let us alert you of changes and developments. Telling us that you are using, hosting, or adapting Electromagnetics allows us to update you regarding collaborative development opportunities, errata, new volumes and editions, supplements and ancillaries, and newly issued print versions. Tell us at: http://bit.ly/vtpublishing-updates Current errata for this volume can be found at: http://www.faculty.ece.vt.edu/swe/oem/Vol1Beta_errata.txt Share Feedback & Suggestions 1. Submit private or anonymous suggestions or feedback to the editor / author at: http://bit.ly/electromagnetics-suggestion 2. Share suggestions by annotating on the document using Hypothes.is https://web.hypothes.is View the guide for using Hypothesis to make comments http://bit.ly/userfeedbackguide 3. Submit additional suggestions via email to: publishing@vt.edu Table of Contents Chapter 1: Preliminary Concepts Chapter 2: Electric and Magnetic Fields Chapter 3: Transmission Lines 29 Chapter 4: Vector Analysis Chapter 5: Electrostatics Chapter 6: Steady Current and Conductivity Chapter 7: Magnetostatics Chapter 8: Time-Varying Fields Chapter 9: Plane Wave Propagation in Lossless Media Appendix A: Constitutive Parameters of Some Common Materials Appendix B: Mathematical Formulas Appendix C: Physical Constants The Open Electromagnetics Project at Virginia Tech: This textbook is part of the Open Electromagnetics Project led by Steven W. Ellingson at Virginia Tech. The goal of the project is to create no-cost openly-licensed content for courses in undergraduate engineering electromagnetics. The project is motivated by two things: lowering learning material costs for students and giving faculty the freedom to adopt, modify, and improve their educational resources. Cover design: Robert Browder Cover image: (c) Michelle Yost. Total Internal Reflection (modified by Robert Browder) is licensed with a Creative Commons Attribution-ShareAlike 2.0 license About the Author: Steven W. Ellingson (ellingson@vt.edu) is an Associate Professor at Virginia Tech in Blacksburg, Virginia in the United States. He received PhD and MS degrees in Electrical Engineering from the Ohio State University and a BS in Electrical & Computer Engineering from Clarkson University. He was employed by the US Army, Booz-Allen & Hamilton, Raytheon, and the Ohio State University ElectroScience Laboratory before joining the faculty of Virginia Tech, where he teaches courses in electromagnetics, radio frequency systems, wireless communications, and signal processing. His research includes topics in wireless communications, radio science, and radio frequency instrumentation. Professor Ellingson serves as a consultant to industry and government and is the author of Radio Systems Engineering (Cambridge University Press, 2016). Suggested citation: Ellingson, Steven W. (2018) Electromagnetics, Vol. 1 (Beta). Blacksburg, VA: VT Publishing. https://doi.org/10.7294/W4WQ01ZM Licensed with CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0 Publication of this book was made possible in part by the Virginia Tech University Libraries Open Education Faculty Initiative Grant program: http://guides.lib.vt.edu/oer/grants PLEASE NOTE: This item has been superceded by a new version: Electromagnetics Volume 1 (August 2018) which is freely available at: https://doi.org/10.21061/electromagnetics-vol-1

The principal aim of the Swiss Household Panel (SHP) is to observe social change, in particular the dynamics of changing living conditions and representations in the population of Switzerland. Covering a broad range of topics and approaches in the social sciences, SHP is a yearly panel with rotating modules following three random samples of private households in Switzerland over time, interviewing all household members, mainly by telephone.
The LIVES FORS Cohort Survey can be essentially seen as an SHP additional sample. The waves of SHP and the LIVES FORS Cohort Survey run in parallel and share most of the questions and modules. That said the LIVES FORS Cohort Survey is distinguished from SHP by a specific reference population and sampling procedure. In addition, only the targeted member of the household has to respond to the individual questionnaire (and not all members as in SHP).

The European NDM-1 Survey Participants: Manuela Caniça (Departamento de Doenças Infecciosas do INSA) ; Acquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat. A novel acquired carbapenemase, New Delhi metallo-beta-lactamase 1 (NDM-1), has recently been described in the United Kingdom and Sweden, mostly in patients who had received care on the Indian subcontinent. We conducted a survey among 29 European countries (the European Union Member States, Iceland and Norway) to gather information on the spread of NDM-1-producing Enterobacteriaceae in Europe, on public health responses and on available national guidance on detection, surveillance and control. A total of 77 cases were reported from 13 countries from 2008 to 2010. Klebsiella pneumoniae was the most frequently reported species with 54%. Among 55 cases with recorded travel history, 31 had previously travelled or been admitted to a hospital in India or Pakistan and five had been hospitalised in the Balkan region. Possible nosocomial acquisition accounted for 13 of 77 cases. National guidance on NDM-1 detection was available in 14 countries and on NDM-1 control in 11 countries. In conclusion, NDM-1 is spreading across Europe, where it is frequently linked to a history of healthcare abroad, but also to emerging nosocomial transmission. National guidance in response to the threat of carbapenemase-producing Enterobacteriaceae is available in approximately half of the surveyed European countries. Surveillance of carbapenemase- producing Enterobacteriaceae must be enhanced in Europe and effective control measures identified and implemented.

Collecting data on households and individuals since 1999, the Swiss Household Panel (SHP) is an ongoing, unique, large-scale, nationally representative, longitudinal study in Switzerland. The data of the SHP provide a rich source of information to study social change in Switzerland over a significant period on a wide variety of topics. The SHP aims to provide both continuity and innovation in measurement and data collection, with the combination of retrospective and prospective longitudinal data in the most recent refreshment sample as one notable example of such an innovation.

WOS: 000329131300012 ; PubMed ID: 24186907 ; Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency. Results. Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2) with OPC in 1 patient, whereas isolated vulvovaginal candidiasis (VVC; n = 3) was not. Five episodes of proven invasive candidiasis were documented in 4 patients; 1 of these episodes was community acquired in the absence of any other comorbid condition. The first episode of candidiasis occurred earlier in life (median age +/- standard deviation, 1.5 +/- 7.87 years) than infections with environmental mycobacteria (4.29 +/- 11.9 years), Mycobacterium tuberculosis (4 +/- 3.12 years), or Salmonella species (4.58 +/- 4.17 years) or other rare infections (3 +/- 11.67 years). Candidiasis was the first documented infection in 19 of the 35 patients, despite the vaccination of 10 of these 19 patients with live bacille Calmette-Guerin. Conclusions. Patients who are deficient in IL-12R beta 1 may have candidiasis, usually mucocutaneous, which is frequently recurrent or persistent. Candidiasis may be the first clinical manifestation in these patients. ; Fondo de Investigaciones Sanitarias, Ministerio de Economia y Competitividad [PI06/1031, PI10/01718]; European Regional Development Fund-European Social Fund (FEDER-FSE); Fundacion Canaria de Investigacion y Salud (Canarian government) [INREDCAN 05/06]; Foundation Caja Rural de Canarias-Chil y Naranjo; Universidad de Las Palmas de Gran Canaria; INSERMInstitut National de la Sante et de la Recherche Medicale (Inserm); University Paris Descartes; Rockefeller University; National Center for Research ResourcesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR); National Center for Advancing Sciences of the National Institutes of Health [8UL1TR000043]; Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases" [ANR-10-LABX-62-IBEID]; European Research Council, Agence Nationale de la RechercheFrench National Research Agency (ANR) [GENCMCD 11-BSV3-005-01]; St Giles Foundation; Candidoser Association; Consejo Nacional de Ciencia y Tecnologia de MexicoConsejo Nacional de Ciencia y Tecnologia (CONACyT) [69992, 182817] ; This work was supported by Fondo de Investigaciones Sanitarias, Ministerio de Economia y Competitividad (grants PI06/1031 and PI10/01718), the European Regional Development Fund-European Social Fund (FEDER-FSE), Fundacion Canaria de Investigacion y Salud (Canarian government; INREDCAN 05/06), Foundation Caja Rural de Canarias-Chil y Naranjo (research prize 2004), Universidad de Las Palmas de Gran Canaria (fellowship to E. H. R), INSERM, University Paris Descartes, Rockefeller University, National Center for Research Resources and the National Center for Advancing Sciences of the National Institutes of Health (grant 8UL1TR000043), Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases" (grant ANR-10-LABX-62-IBEID), the European Research Council, Agence Nationale de la Recherche (grant GENCMCD 11-BSV3-005-01), the St Giles Foundation, the Candidoser Association, and Consejo Nacional de Ciencia y Tecnologia de Mexico (grants 69992 and 182817).