Suchergebnisse

Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. We recently discovered that green tea extracts containing epigallocatechin-3-gallate (EGCG) improve cognition in mice transgenic for Dyrk1a (TgDyrk1A) and in a trisomic DS mouse model (Ts65Dn). Interestingly, paired with cognitive stimulation, green tea has beneficial pro-cognitive effects in DS individuals. Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (DYRK1A) is a major candidate to explain the cognitive phenotypes of DS, and inhibiting its activity is a promising pro-cognitive therapy. DYRK1A kinase activity can be normalized in the hippocampus of transgenic DYRK1A mice administering green tea extracts, but also submitting the animals to environmental enrichment (EE). However, many other mechanisms could also explain the pro-cognitive effects of green tea extracts and EE. To underpin the overall alterations arising upon DYRK1A overexpression and the molecular processes underneath the pro-cognitive effects, we used quantitative proteomics. We investigated the hippocampal (phospho)proteome in basal conditions and after treatment with a green tea extract containing EGCG and/or EE in TgDyrk1A and control mice. We found that Dyrk1A overexpression alters protein and phosphoprotein levels of key postsynaptic and plasticity-related pathways and that these alterations were rescued upon the cognitive enhancer treatments. ; The work has received financial support from MINECO (SAF2016-79956-R), Jerome Lejeune Foundation (Project #1347 "Elucidation of the mechanism of action of epigallocatechin-3-gallate as a therapeutic agent on the cognitive phenotype in Down Syndrome mice models"), and the NIH 1R01EB 028159-01 to MD, the Centre for Genomic Regulation Severo Ochoa excellence grant (SEV-2012-0208), the Centro de Investigación Biomédica en Red Enfermedades Raras (CIBER) of Rare Diseases; "Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya" (Grups consolidats SGR 2016/1125, and 2017SGR595); and the "Centro para el Desarrollo Tecnológico Industrial CDTI." The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of Proteored, PRB3, and is supported by grant PT17/0019, of the PE I+D+i 2013–2016, funded by ISCIII. ID received funding from the People Program (Marie Curie Actions) of the European Union's Seventh Framework Program (FP7/2007-2013) under REA grant agreement n° 608959. MO received an FPI Severo Ochoa Doctoral Fellowship from the Spanish Ministry of Economy and Finance (MINECO) SVP-2013-068022 during the period 2014–2018 and a short research international stay fellowship (EEBB-I-16-11305).

Innenpolitische Entwicklung Burundis zwischen 1972 und 1988. Beide Jahre markieren Eskalationen ethnischer Konflikte zwischen den Völkern der Hutu und der Tutsi, bei denen Zehntausende von Menschen umkamen

ABORTION HAS PERSISTED AS A CONTROVERSIAL ISSUE IN THE UNITED STATES SINCE 1973. TO DISCOVER HOW ABORTION HAS AFFECTED THE PRESIDENCY AND PARTY POLITICS, THIS STUDY EXAMINES ABORTION POLICY IN PARTY PLATFORMS, ABORTION DEBATES DURING PRESIDENTIAL CAMPAIGNS, AND PRESIDENTIAL VOTING BEHAVIOR REGARDING ABORTION. ALTHOUGH PRESIDENTIAL CANDIDATES HAVE MADE THEIR VIEWS ON ABORTION KNOWN SINCE THE EARLY 1970'S, NATIONAL ELECTION SURVEY DATA AND POLLING DATA SUGGEST THAT PRESIDENTIAL CANDIDATES HAVE NOT BEEN SELECTED ON THE BASIS OF THEIR STANCE ON ABORTION.

Examines abortion policy in party platforms, debates during presidential campaigns, and presidential voting behavior to assess the impact of abortion politics on the electorate.

p. 45-77 ; The 'Tumult of Toruń' of 1724, which resulted in the sentencing to death of the mayor and a dozen or so townsmen (the so-called 'bloodbath' or 'bloody court'), brought about a veritable deluge of publications. It has become widely accepted in literature that these writings fundamentally impacted the development in Western public opinion of the notion that eighteenth-century Poland was an intolerant country. In 1767–71, Voltaire placed his pen at the service of the Russian empress, and his propaganda texts provided support for the diplomatic and military offensive of the court of Saint Petersburg in Poland. One of the more significant themes that appeared in the papers commissioned by the Russians and also in the philosopher's correspondence was that of the 'Tumult of Toruń' of July 1724 and the death sentences that were passed against the city's mayor and a dozen or so townspeople. ; s. 45-77 ; The 'Tumult of Toruń' of 1724, which resulted in the sentencing to death of the mayor and a dozen or so townsmen (the so-called 'bloodbath' or 'bloody court'), brought about a veritable deluge of publications. It has become widely accepted in literature that these writings fundamentally impacted the development in Western public opinion of the notion that eighteenth-century Poland was an intolerant country. In 1767–71, Voltaire placed his pen at the service of the Russian empress, and his propaganda texts provided support for the diplomatic and military offensive of the court of Saint Petersburg in Poland. One of the more significant themes that appeared in the papers commissioned by the Russians and also in the philosopher's correspondence was that of the 'Tumult of Toruń' of July 1724 and the death sentences that were passed against the city's mayor and a dozen or so townspeople.

[spa] Tras el establecimiento de los españoles en Filipinas a partir de 1565, la orden de San Agustín, como principal congregación religiosa en el archipiélago, se convirtió en la mejor posicionada para entrar en China y fundar una misión. Sin embargo, este objetivo sería difícil de conseguir, a pesar de que, por su papel de agentes religiosos y a la vez políticos, al servicio de Felipe II, contaron con encargos diplomáticos como los protagonizados por fray Martín de Rada o fray Juan González de Mendoza. Sus acciones les permitieron esbozar una primera y coherente imagen de China. Un retrato que se adelanta a la sofisticada imagen que pocos años después construirían los jesuitas. Estas visiones constituyen la primera gran contribución a la sinología europea de los tiempos modernos. ; [cat] Després de l'establiment dels espanyols a les Filipines a partir de 1565, l'orde de sant Agustí, com a principal congregació religiosa a l'arxipèlag, es va convertir en el més ben posicionat per entrar a la Xina i fundar-hi una missió. No obstant això, aquest objectiu seria difícil d'aconseguir, tot i que, pel seu paper d'agents religiosos i alhora polítics al servei de Felip II, van rebre encàrrecs diplomàtics com els protagonitzats per fra Martín de Rada o fra Juan González de Mendoza. Les seves accions els van permetre esbossar una primera i coherent imatge de la Xina. Un retrat que s'avança a la sofisticada imatge que pocs anys després construirien els jesuïtes. Aquestes visions constitueixen la primera gran contribució a la sinologia europea d'època moderna ; [eng] After the establishment of the Spanish in the Philippines in 1565, the Order of St. Augustine, as the main religious congregation in the archipelago, became the best positioned to enter in China and found a mission. However, this aim would be difficult to achieve, even though due to their role as religious and political agents at the service of Felipe II they had diplomatic assignments, such as the embassies commissioned to Fray Martín de Rada and Fray Juan González de Mendoza. Their actions allowed them to sketch a first and coherent image of China, ahead of the sophisticated image that the Jesuits would build a few years later. These impressions are the first major contribution to European sinology of early modern times.

[spa] Este artículo trata de adentrarse en las interioridades del oficio de maestro de ceremonias en el Nápoles virreinal del primer tercio del siglo XVII. A través de sus textos, los libros de ceremonias, se explica una interpretación política, simbólica y gobernativa de un corpus ceremonial rico que culminó en el 'Libro de los Virreyes' del ceremoniero Jusepe Renao, de 1634-1637. La lectura y análisis de este manuscrito, conservado en la Biblioteca Nacional de España, permite dibujar un completo viaje ceremonial a la corte partenopea de los virreyes españoles. ; [eng] This article wants to analyze the exercise of the practice of government and political representation through the ceremonial testimonies, the books of ceremonies, in the vice royal Naples of the first third of the 17th century. The rich ceremonial corpus of the Neapolitan viceroyalty culminated in the Libro de los Virreyes (1634 - 1637) of Jusepe Renao. A personal and professional profile of Renao is also presented. The reading and analysis of this manuscript, preserved in the Biblioteca Nacional de España, with two more ceremonial sources and other contemporary witnesses, offers a complete ceremonial trip to the Neapolitan court of the Spanish viceroys, a journey that occupies the second part of this work.

"Information Technology Law is the ideal companion for a course of study on IT law and the ways in which it is evolving in response to rapid technological and social change. This ground-breaking new work is the first textbook to systematically examine how the law and legal process of the UK interacts with the modern 'information society' and the fast-moving process of digitization. It examines the challenges that this fast pace of change brings to the established legal order, which was developed to meet the needs of a traditional physical society. To address these issues, this book begins by defining the information society and discussing how it may be regulated. From there it moves to questions of internet governance and rights and responsibilities in the digital environment. Particular attention is paid to key regulatory 'pressure points', including: DT copyright for digital products DT identity fraud DT electronic commerce DT privacy and surveillance Possible future challenges and opportunities are outlined and discussed, including e-government, virtual environments and property, and the development of web 3.0. Information Technology Law: The law and society covers all aspects of a course of study on IT law, and is therefore an ideal text for students. The author's highly original and thought-provoking approach to the subject also makes it essential reading for researchers, IT professionals and policymakers. Online Resource Centre This book is accompanied by an Online Resource Centre containing the following resources for students: DT Regular podcast updates from the author DT A selection of useful web links DT A glossary of key terms DT A link to the author's IT law blog"--

p. 181-206 ; This text summarises the results of extensive research into the relationship between the state and universities in 1849–1939, i.e. between the so-called 'Thun reform' and the closure of Czech universities by the Nazis. The focus is on the state's respect for the privileged position of universities and the monitoring of tensions arising from the clash between legislation and the universities' day-to-day operations, resulting mainly from satisfying the economic needs of universities on the one hand, and the interpretation of the responsibility and discipline of their academic staff towards the state and society on the other. The research shows the advancing erosion of the so-called Prussian (Humboldt's) concept of an autonomous national-oriented university and the difficult search for a democratic alternative in interwar Central Europe's unstable political and economic conditions. ; s. 181-206 ; This text summarises the results of extensive research into the relationship between the state and universities in 1849–1939, i.e. between the so-called 'Thun reform' and the closure of Czech universities by the Nazis. The focus is on the state's respect for the privileged position of universities and the monitoring of tensions arising from the clash between legislation and the universities' day-to-day operations, resulting mainly from satisfying the economic needs of universities on the one hand, and the interpretation of the responsibility and discipline of their academic staff towards the state and society on the other. The research shows the advancing erosion of the so-called Prussian (Humboldt's) concept of an autonomous national-oriented university and the difficult search for a democratic alternative in interwar Central Europe's unstable political and economic conditions.

Transcript of annual speech given by Governor Nikki R. Haley to both houses of the state legislature in joint opening session to report on the condition of the state of South Carolina.

Due to the hazardous driving conditions caused by a winter storm, state government offices delayed opening on January 14, 2015. Governor Nikki Haley grants leave with pay to state employees in Fairfield and Lancaster Counties for the hours missed due to the delayed opening of State offices.

This veto message from Governor Nikki Haley vetoes R205, S.293, a bill that raises the cap on property taxes for the Murrell's Inlet-Garden City Fire District from 10 mills to 14 mills.