Suchergebnisse

O consumo de produtos de origem animal é expressivo, no entanto, muitos consumidores, especialmente os que vivem em centros urbanos, desconhecem a origem desses produtos e os processos pelos quais passam até chegarem às suas mesas. Iniciado em 2016 em Santarém, PA, o projeto "De Onde Vêm?!" objetiva compartilhar com a comunidade, principalmente em áreas urbanas sem ligação direta com a produção agropecuária, o conhecimento sobre a origem dos alimentos, a cadeia produtiva associada e desmistificar fake news acerca dos produtos de origem animal. O projeto encontra-se e desmistificar fake news acerca dos produtos de origem animal. O projeto encontra-se em sua nona edição, e no período de julho de 2023 a junho de 2024, discentes dos cursos de Zootecnia, Agronomia, Biotecnologia e Biologia, com apoio e orientação do corpo docente e técnico da UFOPA, protagonizaram ações de extensão universitária, que foram direcionadas principalmente para o público-alvo: estudantes e professores da educação básica, estudantes de instituições públicas e privadas de ensino superior da região, e idosos participantes de atividades físicas nas Unidades Básicas de Saúde de Santarém, PA. Ao envolver diferentes faixas etárias e níveis educacionais, o projeto não só contribuiu para a formação acadêmica dos estudantes, como também forneceu à comunidade informações valiosas sobre a cadeia produtiva de alimentos, evidenciando o sucesso e a eficácia das ações realizadas através de uma expressiva participação da população.

Abstract
Pollinosis, also known as pollen allergy or hay fever, is a global problem caused by pollen produced by various plant species. The wind-pollinated Japanese cedar (Cryptomeria japonica) is the largest contributor to severe pollinosis in Japan, where increasing proportions of people have been affected in recent decades. The MALE STERILITY 4 (MS4) locus of Japanese cedar controls pollen production, and its homozygous mutants (ms4/ms4) show abnormal pollen development after the tetrad stage and produce no mature pollen. In this study, we narrowed down the MS4 locus by fine mapping in Japanese cedar and found TETRAKETIDE α-PYRONE REDUCTASE 1 (TKPR1) gene in this region. Transformation experiments using Arabidopsis thaliana showed that single-nucleotide substitution ("T" to "C" at 244-nt position) of CjTKPR1 determines pollen production. Broad conservation of TKPR1 beyond plant division could lead to the creation of pollen-free plants not only for Japanese cedar but also for broader plant species.

AbstractIntroductionLate diagnosis of the human immunodeficiency virus (HIV) is a major concern epidemiologically, socially and for national healthcare systems. Although the association of certain demographics with late HIV diagnosis has been reported in several studies, the association of other factors, including clinical and phylogenetic factors, remains unclear. In the present study, we conducted a nationwide analysis to explore the association of demographics, clinical factors, HIV‐1 subtypes/circulating recombinant form (CRFs) and genetic clustering with late HIV diagnosis in Japan, where new infections mainly occur among young men who have sex with men (MSM) in urban areas.MethodsAnonymized data on demographics, clinical factors and HIV genetic sequences from 39.8% of people newly diagnosed with HIV in Japan were collected by the Japanese Drug Resistance HIV‐1 Surveillance Network from 2003 to 2019. Factors associated with late HIV diagnosis (defined as HIV diagnosis with a CD4 count <350 cells/μl) were identified using logistic regression. Clusters were identified by HIV‐TRACE with a genetic distance threshold of 1.5%.ResultsOf the 9422 people newly diagnosed with HIV enrolled in the surveillance network between 2003 and 2019, 7752 individuals with available CD4 count at diagnosis were included. Late HIV diagnosis was observed in 5522 (71.2%) participants. The overall median CD4 count at diagnosis was 221 (IQR: 62–373) cells/μl. Variables independently associated with late HIV diagnosis included age (adjusted odds ratio [aOR] 2.21, 95% CI 1.88–2.59, ≥45 vs. ≤29 years), heterosexual transmission (aOR 1.34, 95% CI 1.11–1.62, vs. MSM), living outside of Tokyo (aOR 1.18, 95% CI 1.05–1.32), hepatitis C virus (HCV) co‐infection (aOR 1.42, 95% CI 1.01–1.98) and not belonging to a cluster (aOR 1.30, 95% CI 1.12–1.51). CRF07_BC (aOR 0.34, 95% CI 0.18–0.65, vs. subtype B) was negatively associated with late HIV diagnosis.ConclusionsIn addition to demographic factors, HCV co‐infection, HIV‐1 subtypes/CRFs and not belonging to a cluster were independently associated with late HIV diagnosis in Japan. These results imply the need for public health programmes aimed at the general population, including but not limited to key populations, to encourage HIV testing.