Suchergebnisse

International audience ; Par deux fois en moins d'un siècle, en 1792 et en 1860, le Duché de Savoie est rattaché à la Grande Nation française à l'issue d'une consultation populaire. Pourtant, au-delà des apparences le contexte comme la signification de chacun de ces évènements diffère sensiblement même si, à l'évidence, ces deux annexions successives de la Savoie à la France se révèlent intimement liées en dépit de leurs soixante-dix ans de distance. Comment en effet comprendre 1860 en faisant artificiellement abstraction du précédent de 1792 ? Tant la référence ambiguë à l'idéologie révolutionnaire contemporaine de la Convention joue, au cours du second épisode, le rôle d'argument de poids en faveur ou à l'encontre du thème de la nécessaire fusion de la petite patrie alpine dans le creuset de la Grande Nation. Peu importe en l'occurrence et très paradoxalement, le retournement soudain de sensibilité politique des militants en faveur de l'option française lors de ces deux événements majeurs de l'histoire alpine occidentale. Puisqu'en toute logique les plus ardents promoteurs de l'Annexion, en 1860, conservateurs cléricaux bon teint, ne devraient pas se prévaloir contre nature d'une référence à ce point connotée à l'Invasion révolutionnaire de la Savoie pour en réclamer ultérieurement les bienfaits. Mais l'histoire des Etats de Savoie et a fortiori celle, en leur sein, des provinces savoyardes proprement dites, s'avère si complexe que les confusions en tout genre se perpétuent avec une désolante constance depuis des lustres, malgré le patient travail de vulgarisation entrepris de longue date par plusieurs générations d'historiens.C'est donc dans un cadre politique résultant d'enjeux doctrinaux de prime abord assez étrangers à l'histoire savoyarde qu'il convient ainsi de replacer l'analyse des deux annexions consécutives de la Savoie à la France, puis celle de leur légitimation, voire de leur amalgame définitif dans la plupart des mémoires locales au gré des cérémonies officielles, dans la construction de récits ...

Fra il 1897 e il 1925 si consuma una delle fasi più importanti della storia della Sicilia d'età contemporanea. L'isola in poco più di un quarto di secolo, dopo le vicende risorgimentali antiborboniche e indipendentiste (nelle quali avevano avuto parte attiva, e di concerto, la più avvertita classe egemone, gli intellettuali e vasti strati della borghesia e del proletariato) e il non facile adeguamento alla pur tanto auspicata nuova compagine dell'Italia unita, inizialmente si avvia ad una stabilizzazione economica e ad un generale progresso sociale. Sono condizioni significative del raggiungimento, a cavallo dei due secoli, di una specifica fisionomia propositiva della sua società come emergente area mercantile; tuttavia esse avranno, nell'arco di tempo in questione, un andamento a parabola con tanto di fase ascendente e successiva discendente che nel 1925 conosce il suo minimo storico dai tempi dell'uscita dell'isola dalla crisi economica internazionale degli anni Settanta del XIX secolo. Uno scenario inimmaginabile fino a quindici o venti anni prima quando, ancora in piena Belle Èpoque, ben altro peso aveva la Sicilia in tanti settori della vita della nazione con personalità come l'imprenditore (armatore, industriale e banchiere) Ignazio Florio junior, gli architetti Ernesto Basile e Giuseppe Damiani Almeyda, gli scultori Mario Rutelli, Domenico Trentacoste, Antonio Ugo ed Ettore Ximenes, i pittori Francesco Lojacono ed Ettore De Maria Bergler, il poeta e scrittore Nino Martoglio, l'archeologo Antonio Salinas, il numismatico Raffaello Mondini, i chirurghi Francesco Durante, Gaetano Parlavecchio ed Ernesto Tricomi, i medici e demopsicologi Giuseppe Pitrè e Salvatore Salomone-Marino, il medico-legale Giuseppe Ziino, il medico e geologo Gaetano Giorgio Gemmellaro, il cristallografo e mineralogista Ruggero Panebianco, il letterato e critico Giovanni Alfredo Cesareo, gli editori Remo Sandron e Salvatore Biondo, gli attori Angelo Musco e Pina Menichelli, il musicista Luigi Sandron, il matematico Giovan Battista Guccia, i filosofi Giuseppe Amato Pojero, Cosmo Guastella, Giovanni Gentile e Francesco Orestano, il chimico Stanislao Cannizzaro, gli scrittori Luigi Capuana, Luigi Pirandello e Giovanni Verga, gli storici Michele Amari e Gioacchino Di Marzo, i costruttori Emanuele Rutelli e Michele Utveggio, il generale Giovanni Ameglio, e personalità del mondo della politica del calibro di Giacomo Armò, Pietro Bonanno, Napoleone Colajanni, Francesco Crispi, Giuseppe De Felice Giuffrida, Salvatore Favitta, Camillo Finocchiaro Aprile, Ludovico Fulci, Nicolò Gallo, Pietro Lanza di Scalea, Pasquale Libertini, Angelo Majorana, Nunzio Nasi, Vittorio Emanuele Orlando, Antonio Paternò Castello di San Giuliano, Antonio Starrabba di Rudinì e Luigi Sturzo. Era una costellazione di personalità eccezionali che, a meno di coloro i quali si trasferirono irreversibilmente nel continente, condivideva con gli altri esponenti locali dell'intellighentia, dei cenacoli artistici, della politica, dell'alta finanza e con la superstite aristocrazia la frequentazione degli stessi luoghi dell'interscambio; teatri, cinematografi, caffè, oppure sedi depositarie di specifiche funzioni culturali (come, a Palermo, il Museo Nazionale, la sede della Società della Storia Patria, la Biblioteca Comunale negli anni in cui è diretta da Gioacchino Di Marzo e principalmente la Civica Galleria d'Arte Moderna, fondata nel 1910 da Empedocle Restivo con la consulenza di Basile, De Maria e Ducrot) ma soprattutto circoli, che unitamente alle sedi istituzionali preposte alla preparazione dei nuovi quadri di esponenti del mondo culturale, professionale e artistico sono da considerare i veri "luoghi di formazione" di questo periodo (segnatamente in casi come il Circolo Matematico, il Circolo Giuridico, il Circolo Artistico e la Biblioteca Filosofica, tutti a Palermo, come il Real Circolo Musicale Bellini di Catania o come gli esclusivi salotti culturali privati di casa Alfano a Palermo o della contessa D'Ajala a Catania). Oltre ad essere una delle regioni con maggior numero di abitanti della nazione (e con il maggior concentramento di grandi centri urbani) la Sicilia, nonostante il permanere di aree rurali depresse e l'affacciarsi di alcuni gravi fenomeni di inurbamento (deteriori per le condizioni di vita e portatori di degrado sociale), poteva contare su un articolato sistema produttivo difformemente esteso anche al mercato estero; questo si verificava tanto nel settore agricolo quanto in quello estrattivo quanto, ancora, in quello industriale (tuttavia il meno incisivo fra i tre quanto a esportazioni). Non mancava nell'isola un'apprezzabile tradizione di iniziative sindacali; alla fine dell'Ottocento la regione era la terza in Italia, dopo la Lombardia e l'Emilia Romagna, per associazioni operaie. Metà di esse erano di orientamento socialista; l'altra metà era di ispirazione cattolica. Invero quella siciliana era una realtà moderatamente (o meglio settorialmente) dinamica e, in qualche modo, costretta dal peso negativo di grandi aree (soprattutto nell'interno dell'isola e in alcuni suoi territori centro-meridionali) innegabilmente affette da profonda arretratezza. Nonostante la discontinuità del suo assetto economico-sociale (fra aree emergenti e sacche di miseria atavica, fra vivacità di alcune realtà urbane, prevalentemente costiere ma in taluni casi anche dell'interno, assolutamente al passo con i tempi e anacronistico immobilismo di tanti centri abitati rurali), era in grado di occupare, anche se solo per alcuni comparti produttivi, posizioni di media, se non alta, rilevanza nell'ampio scacchiere della tarda età della "civiltà capitalista" europea. Fra i settori trainanti dell'economia siciliana della Belle Èpoque ad eccellere erano l'industria estrattiva, l'industria enologica e quella dei distillati, le compagnie di navigazione, la cantieristica navale, gli istituti di credito, l'industria di mobili e arredi, la pesca e l'industria di inscatolamento del tonno, l'industria delle lavorazioni in cemento, l'industria olearia, la produzione e lavorazione del sale, l'industria chimica e farmaceutica, la produzione agrumaria e l'estrazione di bitumi. A partire dall'attuazione dei piani regolatori e di ampliamento delle principali città siciliane, in un arco temporale che va dalla metà degli anni Novanta del XIX secolo alla metà degli anni Venti del XX secolo, sarà l'industria edilizia a fare la sua comparsa prepotente nello scenario delle attività produttive dell'isola. In effetti soprattutto i primi tre lustri del Novecento vedono alcune fra le più attive città siciliane impegnate in complessi fenomeni di rinnovamento. A parte il caso limite di Messina, interamente distrutta dal sisma e dal maremoto del 1908 e già in fase di ricostruzione alla metà degli anni Dieci sulle linee del Piano Regolatore redatto da Luigi Borzì nel 1911 (mentre ancora facevano bella mostra di sé i quartieri delle baracche in legno, esibendo un ampio ventaglio di pregevoli soluzioni tecnologiche, tipologiche e formali), si registrano consistenti mutazioni della forma urbana in città come Caltagirone, felicemente investita dall'attivismo del movimento municipalista di Luigi Sturzo, Siracusa, proiettata con il Piano Regolatore di Luigi Mauceri (nella versione del 1910) verso un salto di qualità urbana e infrastrutturale poi in parte disatteso, Agrigento, con il suo episodico ma cospicuo ampliamento panoramico lineare del viale delle Vittorie, per non parlare di Caltanissetta (primo fra i comuni dell'Italia appena unificata a dotarsi di un piano regolatore), Catania, Palermo e Trapani, che nei due decenni antecedenti al primo conflitto mondiale vanno completando, con considerevole presenza di architetture liberty, i rispettivi nuovi assetti delineati dai piani regolatori e di ampliamento d'età positivista. È la ricaduta della consistente accumulazione di capitali, verificatasi nella seconda metà del XIX secolo, e che però riguarda solo alcune aree e contesti urbani economicamente emergenti, vuoi per attività industriali, mercantili o estrattive (emblematici in tal senso sono, tra l'altro, i casi di Marsala e di Licata oltre, ovviamente, Caltagirone, Caltanissetta, Catania, Messina, Palermo, Ragusa e Trapani), vuoi per un rilancio della produttività agricola (che interessa centri come Avola, Canicattì, Canicattini Bagni, Ispica, Modica, Palazzolo Acreide, Scicli, Vittoria, ma anche Caltagirone, Licata e Marsala) propugnato e sostenuto da una agguerrita fazione riformista di proprietari terrieri di orientamento filantropico (con in testa il barone Lombardo Gangitano, il barone Chiaramonte Bordonaro, il conte Tasca d'Almerita, il principe Bruno di Belmonte). Questa realtà economica innesterà un vasto processo di produzione edilizia in un arco temporale limitato; un fenomeno la cui dimensione, relativamente alla storia isolana, ha come precedenti solamente le ricostruzioni settecentesche (in realtà ben più diluite nel tempo) di Catania, di Messina e delle città e dei paesi del Val di Noto dopo i rispettivi cataclismi.

National audience ; L'Annexion de 1860 est-elle un événement religieux ? Cette interrogation est le fil rouge des textes réunis dans ce volume qui reproduit les communications données lors de la journée d'étude chambérienne du 26 mai 2010. Les auteurs abordent tour à tour les enjeux pastoraux et les débats politiques, le rôle des personnalités et les singularités géographiques, les aspects juridiques et les représentations collectives. Ils contribuent ainsi à éclairer les évènements de l'année 1860 et à comprendre les choix de la société savoyarde, marquée par le catholicisme, mais aussi parcourue par les courants du siècle qui remettent en cause les valeurs religieuses. Avec les contributions de Monseigneur Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier et Philippe Boutry. ; L'Annessione del 1860 è un avvenimento religioso? Questa interrogazione è il filo rosso dei testi riuniti in questo volume che riproduce le comunicazioni date all'epoca della giornata di studio di Chambéy del 26 maggio 2010. Gli autori abbordano uno dopo l'altro le poste pastorali ed i dibattimenti politici, il ruolo delle personalità e le singolarità geografiche, gli aspetti giuridici e le rappresentazioni collettive. Contribuiscono così ad illuminare i avvenimenti dell'anno 1860 ed a comprendere le scelte della società savoiarda, contrassegnata per il cattolicesimo, ma percorsa anche dalle correnti del secolo che rimettono in causa i valori religiosi. Coi contributi del Monsignore Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier e Philippe Boutry.

National audience ; L'Annexion de 1860 est-elle un événement religieux ? Cette interrogation est le fil rouge des textes réunis dans ce volume qui reproduit les communications données lors de la journée d'étude chambérienne du 26 mai 2010. Les auteurs abordent tour à tour les enjeux pastoraux et les débats politiques, le rôle des personnalités et les singularités géographiques, les aspects juridiques et les représentations collectives. Ils contribuent ainsi à éclairer les évènements de l'année 1860 et à comprendre les choix de la société savoyarde, marquée par le catholicisme, mais aussi parcourue par les courants du siècle qui remettent en cause les valeurs religieuses. Avec les contributions de Monseigneur Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier et Philippe Boutry. ; L'Annessione del 1860 è un avvenimento religioso? Questa interrogazione è il filo rosso dei testi riuniti in questo volume che riproduce le comunicazioni date all'epoca della giornata di studio di Chambéy del 26 maggio 2010. Gli autori abbordano uno dopo l'altro le poste pastorali ed i dibattimenti politici, il ruolo delle personalità e le singolarità geografiche, gli aspetti giuridici e le rappresentazioni collettive. Contribuiscono così ad illuminare i avvenimenti dell'anno 1860 ed a comprendere le scelte della società savoiarda, contrassegnata per il cattolicesimo, ma percorsa anche dalle correnti del secolo che rimettono in causa i valori religiosi. Coi contributi del Monsignore Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier e Philippe Boutry.

National audience ; L'Annexion de 1860 est-elle un événement religieux ? Cette interrogation est le fil rouge des textes réunis dans ce volume qui reproduit les communications données lors de la journée d'étude chambérienne du 26 mai 2010. Les auteurs abordent tour à tour les enjeux pastoraux et les débats politiques, le rôle des personnalités et les singularités géographiques, les aspects juridiques et les représentations collectives. Ils contribuent ainsi à éclairer les évènements de l'année 1860 et à comprendre les choix de la société savoyarde, marquée par le catholicisme, mais aussi parcourue par les courants du siècle qui remettent en cause les valeurs religieuses. Avec les contributions de Monseigneur Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier et Philippe Boutry. ; L'Annessione del 1860 è un avvenimento religioso? Questa interrogazione è il filo rosso dei testi riuniti in questo volume che riproduce le comunicazioni date all'epoca della giornata di studio di Chambéy del 26 maggio 2010. Gli autori abbordano uno dopo l'altro le poste pastorali ed i dibattimenti politici, il ruolo delle personalità e le singolarità geografiche, gli aspetti giuridici e le rappresentazioni collettive. Contribuiscono così ad illuminare i avvenimenti dell'anno 1860 ed a comprendere le scelte della società savoiarda, contrassegnata per il cattolicesimo, ma percorsa anche dalle correnti del secolo che rimettono in causa i valori religiosi. Coi contributi del Monsignore Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier e Philippe Boutry.

National audience ; L'Annexion de 1860 est-elle un événement religieux ? Cette interrogation est le fil rouge des textes réunis dans ce volume qui reproduit les communications données lors de la journée d'étude chambérienne du 26 mai 2010. Les auteurs abordent tour à tour les enjeux pastoraux et les débats politiques, le rôle des personnalités et les singularités géographiques, les aspects juridiques et les représentations collectives. Ils contribuent ainsi à éclairer les évènements de l'année 1860 et à comprendre les choix de la société savoyarde, marquée par le catholicisme, mais aussi parcourue par les courants du siècle qui remettent en cause les valeurs religieuses. Avec les contributions de Monseigneur Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier et Philippe Boutry. ; L'Annessione del 1860 è un avvenimento religioso? Questa interrogazione è il filo rosso dei testi riuniti in questo volume che riproduce le comunicazioni date all'epoca della giornata di studio di Chambéy del 26 maggio 2010. Gli autori abbordano uno dopo l'altro le poste pastorali ed i dibattimenti politici, il ruolo delle personalità e le singolarità geografiche, gli aspetti giuridici e le rappresentazioni collettive. Contribuiscono così ad illuminare i avvenimenti dell'anno 1860 ed a comprendere le scelte della società savoiarda, contrassegnata per il cattolicesimo, ma percorsa anche dalle correnti del secolo che rimettono in causa i valori religiosi. Coi contributi del Monsignore Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier e Philippe Boutry.

National audience ; L'Annexion de 1860 est-elle un événement religieux ? Cette interrogation est le fil rouge des textes réunis dans ce volume qui reproduit les communications données lors de la journée d'étude chambérienne du 26 mai 2010. Les auteurs abordent tour à tour les enjeux pastoraux et les débats politiques, le rôle des personnalités et les singularités géographiques, les aspects juridiques et les représentations collectives. Ils contribuent ainsi à éclairer les évènements de l'année 1860 et à comprendre les choix de la société savoyarde, marquée par le catholicisme, mais aussi parcourue par les courants du siècle qui remettent en cause les valeurs religieuses. Avec les contributions de Monseigneur Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier et Philippe Boutry. ; L'Annessione del 1860 è un avvenimento religioso? Questa interrogazione è il filo rosso dei testi riuniti in questo volume che riproduce le comunicazioni date all'epoca della giornata di studio di Chambéy del 26 maggio 2010. Gli autori abbordano uno dopo l'altro le poste pastorali ed i dibattimenti politici, il ruolo delle personalità e le singolarità geografiche, gli aspetti giuridici e le rappresentazioni collettive. Contribuiscono così ad illuminare i avvenimenti dell'anno 1860 ed a comprendere le scelte della società savoiarda, contrassegnata per il cattolicesimo, ma percorsa anche dalle correnti del secolo che rimettono in causa i valori religiosi. Coi contributi del Monsignore Philippe Ballot, Christian Sorrel, Robert Soldo, Jean-Marc Ticchi, Franck Roubeau, Esther Deloche, Bruno Berthier e Philippe Boutry.

BACKGROUND: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. RESULTS: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory. CONCLUSION: We conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens. ; The work of IF was funded, in part, by the National Science Foundation award DBI-1458359. The work of CSG and AJL was funded, in part, by the National Science Foundation award DBI-1458390 and GBMF 4552 from the Gordon and Betty Moore Foundation. The work of DAH and KAL was funded, in part, by the National Science Foundation award DBI-1458390, National Institutes of Health NIGMS P20 GM113132, and the Cystic Fibrosis Foundation CFRDP STANTO19R0. The work of AP, HY, AR, and MT was funded by BBSRC grants BB/K004131/1, BB/F00964X/1 and BB/M025047/1, Consejo Nacional de Ciencia y Tecnología Paraguay (CONACyT) grants 14-INV-088 and PINV15-315, and NSF Advances in BioInformatics grant 1660648. The work of JC was partially supported by an NIH grant (R01GM093123) and two NSF grants (DBI 1759934 and IIS1763246). ACM acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC 2155 "RESIST" - Project ID 39087428. DK acknowledges the support from the National Institutes of Health (R01GM123055) and the National Science Foundation (DMS1614777, CMMI1825941). PB acknowledges the support from the National Institutes of Health (R01GM60595). GB and BZK acknowledge the support from the National Science Foundation (NSF 1458390) and NIH DP1MH110234. FS was funded by the ERC StG 757700 "HYPER-INSIGHT" and by the Spanish Ministry of Science, Innovation and Universities grant BFU2017-89833-P. FS further acknowledges the funding from the Severo Ochoa award to the IRB Barcelona. TS was funded by the Centre of Excellence project "BioProspecting of Adriatic Sea", co-financed by the Croatian Government and the European Regional Development Fund (KK.01.1.1.01.0002). The work of SK was funded by ATT Tieto käyttöön grant and Academy of Finland. JB and HM acknowledge the support of the University of Turku, the Academy of Finland and CSC – IT Center for Science Ltd. TB and SM were funded by the NIH awards UL1 TR002319 and U24 TR002306. The work of CZ and ZW was funded by the National Institutes of Health R15GM120650 to ZW and start-up funding from the University of Miami to ZW. The work of PWR was supported by the National Cancer Institute of the National Institutes of Health under Award Number U01CA198942. PR acknowledges NSF grant DBI-1458477. PT acknowledges the support from Helsinki Institute for Life Sciences. The work of AJM was funded by the Academy of Finland (No. 292589). The work of FZ and WT was funded by the National Natural Science Foundation of China (31671367, 31471245, 91631301) and the National Key Research and Development Program of China (2016YFC1000505, 2017YFC0908402]. CS acknowledges the support by the Italian Ministry of Education, University and Research (MIUR) PRIN 2017 project 2017483NH8. SZ is supported by the National Natural Science Foundation of China (No. 61872094 and No. 61572139) and Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01). PLF and RLH were supported by the National Institutes of Health NIH R35-GM128637 and R00-GM097033. JG, DTJ, CW, DC, and RF were supported by the UK Biotechnology and Biological Sciences Research Council (BB/N019431/1, BB/L020505/1, and BB/L002817/1) and Elsevier. The work of YZ and CZ was funded in part by the National Institutes of Health award GM083107, GM116960, and AI134678; the National Science Foundation award DBI1564756; and the Extreme Science and Engineering Discovery Environment (XSEDE) award MCB160101 and MCB160124. The work of BG, VP, RD, NS, and NV was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No. 173001. The work of YWL, WHL, and JMC was funded by the Taiwan Ministry of Science and Technology (106-2221-E-004-011-MY2). YWL, WHL, and JMC further acknowledge the support from "the Human Project from Mind, Brain and Learning" of the NCCU Higher Education Sprout Project by the Taiwan Ministry of Education and the National Center for High-performance Computing for computer time and facilities. The work of IK and AB was funded by Montana State University and NSF Advances in Biological Informatics program through grant number 0965768. BR, TG, and JR are supported by the Bavarian Ministry for Education through funding to the TUM. The work of RB, VG, MB, and DCEK was supported by the Simons Foundation, NIH NINDS grant number 1R21NS103831-01 and NSF award number DMR-1420073. CJJ acknowledges the funding from a University of Illinois at Chicago (UIC) Cancer Center award, a UIC College of Liberal Arts and Sciences Faculty Award, and a UIC International Development Award. The work of ML was funded by Yad Hanadiv (grant number 9660 /2019). The work of OL and IN was funded by the National Institute of General Medical Science of the National Institute of Health through GM066099 and GM079656. Research Supporting Plan (PSR) of University of Milan number PSR2018-DIP-010-MFRAS. AWV acknowledges the funding from the BBSRC (CASE studentship BB/M015009/1). CD acknowledges the support from the Swiss National Science Foundation (150654). CO and MJM are supported by the EMBL-European Bioinformatics Institute core funds and the CAFA BBSRC BB/N004876/1. GG is supported by CAFA BBSRC BB/N004876/1. SCET acknowledges funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 778247 (IDPfun) and from COST Action BM1405 (NGP-net). SEB was supported by NIH/NIGMS grant R01 GM071749. The work of MLT, JMR, and JMF was supported by the National Human Genome Research Institute of the National of Health, grant numbers U41 HG007234. The work of JMF and JMR was also supported by INB Grant (PT17/0009/0001 - ISCIII-SGEFI / ERDF). VA acknowledges the funding from TUBITAK EEEAG-116E930. RCA acknowledges the funding from KanSil 2016K121540. GV acknowledges the funding from Università degli Studi di Milano - Project "Discovering Patterns in Multi-Dimensional Data" and Project "Machine Learning and Big Data Analysis for Bioinformatics". SZ is supported by the National Natural Science Foundation of China (No. 61872094 and No. 61572139) and Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01). RY and SY are supported by the 111 Project (NO. B18015), the key project of Shanghai Science & Technology (No. 16JC1420402), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), and ZJLab. ST was supported by project Ribes Network POR-FESR 3S4H (No. TOPP-ALFREVE18-01) and PRID/SID of University of Padova (No. TOPP-SID19-01). CZ and ZW were supported by the NIGMS grant R15GM120650 to ZW and start-up funding from the University of Miami to ZW. The work of MK and RH was supported by the funding from King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. URF/1/3454-01-01 and URF/1/3790-01-01. The work of SDM is funded, in part, by NSF award DBI-1458443 ; Sí

BACKGROUND: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. RESULTS: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory. CONCLUSION: We conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens. ; The work of IF was funded, in part, by the National Science Foundation award DBI-1458359. The work of CSG and AJL was funded, in part, by the National Science Foundation award DBI-1458390 and GBMF 4552 from the Gordon and Betty Moore Foundation. The work of DAH and KAL was funded, in part, by the National Science Foundation award DBI-1458390, National Institutes of Health NIGMS P20 GM113132, and the Cystic Fibrosis Foundation CFRDP STANTO19R0. The work of AP, HY, AR, and MT was funded by BBSRC grants BB/K004131/1, BB/F00964X/1 and BB/M025047/1, Consejo Nacional de Ciencia y Tecnologia Paraguay (CONACyT) grants 14-INV-088 and PINV15-315, and NSF Advances in BioInformatics grant 1660648. The work of JC was partially supported by an NIH grant (R01GM093123) and two NSF grants (DBI 1759934 and IIS1763246). ACM acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy -EXC 2155 "RESIST" - Project ID 39087428. DK acknowledges the support from the National Institutes of Health (R01GM123055) and the National Science Foundation (DMS1614777, CMMI1825941). PB acknowledges the support from the National Institutes of Health (R01GM60595). GB and BZK acknowledge the support from the National Science Foundation (NSF 1458390) and NIH DP1MH110234. FS was funded by the ERC StG 757700 "HYPER-INSIGHT" and by the Spanish Ministry of Science, Innovation and Universities grant BFU2017-89833-P. FS further acknowledges the funding from the Severo Ochoa award to the IRB Barcelona. TS was funded by the Centre of Excellence project "BioProspecting of Adriatic Sea", co-financed by the Croatian Government and the European Regional Development Fund (KK.01.1.1.01.0002). The work of SK was funded by ATT Tieto kayttoon grant and Academy of Finland. JB and HM acknowledge the support of the University of Turku, the Academy of Finland and CSC -IT Center for Science Ltd. TB and SM were funded by the NIH awards UL1 TR002319 and U24 TR002306. The work of CZ and ZW was funded by the National Institutes of Health R15GM120650 to ZW and start-up funding from the University of Miami to ZW. The work of PWR was supported by the National Cancer Institute of the National Institutes of Health under Award Number U01CA198942. PR acknowledges NSF grant DBI-1458477. PT acknowledges the support from Helsinki Institute for Life Sciences. The work of AJM was funded by the Academy of Finland (No. 292589). The work of FZ and WT was funded by the National Natural Science Foundation of China (31671367, 31471245, 91631301) and the National Key Research and Development Program of China (2016YFC1000505, 2017YFC0908402]. CS acknowledges the support by the Italian Ministry of Education, University and Research (MIUR) PRIN 2017 project 2017483NH8. SZ is supported by the National Natural Science Foundation of China (No. 61872094 and No. 61572139) and Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01). PLF and RLH were supported by the National Institutes of Health NIH R35-GM128637 and R00-GM097033. JG, DTJ, CW, DC, and RF were supported by the UK Biotechnology and Biological Sciences Research Council (BB/N019431/1, BB/L020505/1, and BB/L002817/1) and Elsevier. The work of YZ and CZ was funded in part by the National Institutes of Health award GM083107, GM116960, and AI134678; the National Science Foundation award DBI1564756; and the Extreme Science and Engineering Discovery Environment (XSEDE) award MCB160101 and MCB160124. The work of BG, VP, RD, NS, and NV was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No. 173001. The work of YWL, WHL, and JMC was funded by the Taiwan Ministry of Science and Technology (106-2221-E-004-011-MY2). YWL, WHL, and JMC further acknowledge the support from "the Human Project from Mind, Brain and Learning" of the NCCU Higher Education Sprout Project by the Taiwan Ministry of Education and the National Center for High-performance Computing for computer time and facilities. The work of IK and AB was funded by Montana State University and NSF Advances in Biological Informatics program through grant number 0965768. BR, TG, and JR are supported by the Bavarian Ministry for Education through funding to the TUM. The work of RB, VG, MB, and DCEK was supported by the Simons Foundation, NIH NINDS grant number 1R21NS103831-01 and NSF award number DMR-1420073. CJJ acknowledges the funding from a University of Illinois at Chicago (UIC) Cancer Center award, a UIC College of Liberal Arts and Sciences Faculty Award, and a UIC International Development Award. The work of ML was funded by Yad Hanadiv (grant number 9660/2019). The work of OL and IN was funded by the National Institute of General Medical Science of the National Institute of Health through GM066099 and GM079656. Research Supporting Plan (PSR) of University of Milan number PSR2018-DIP-010-MFRAS. AWV acknowledges the funding from the BBSRC (CASE studentship BB/M015009/1). CD acknowledges the support from the Swiss National Science Foundation (150654). CO and MJM are supported by the EMBL-European Bioinformatics Institute core funds and the CAFA BBSRC BB/N004876/1. GG is supported by CAFA BBSRC BB/N004876/1. SCET acknowledges funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 778247 (IDPfun) and from COST Action BM1405 (NGP-net). SEB was supported by NIH/NIGMS grant R01 GM071749. The work of MLT, JMR, and JMF was supported by the National Human Genome Research Institute of the National of Health, grant numbers U41 HG007234. The work of JMF and JMR was also supported by INB Grant (PT17/0009/0001 - ISCIII-SGEFI/ERDF). VA acknowledges the funding from TUBITAK EEEAG-116E930. RCA acknowledges the funding from KanSil 2016K121540. GV acknowledges the funding from Universita degli Studi di Milano - Project "Discovering Patterns in Multi-Dimensional Data" and Project "Machine Learning and Big Data Analysis for Bioinformatics". SZ is supported by the National Natural Science Foundation of China (No. 61872094 and No. 61572139) and Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01). RY and SY are supported by the 111 Project (NO. B18015), the key project of Shanghai Science & Technology (No. 16JC1420402), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), and ZJLab. ST was supported by project Ribes Network POR-FESR 3S4H (No. TOPP-ALFREVE18-01) and PRID/SID of University of Padova (No. TOPP-SID19-01). CZ and ZW were supported by the NIGMS grant R15GM120650 to ZW and start-up funding from the University of Miami to ZW. The work of MK and RH was supported by the funding from King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. URF/1/3454-01-01 and URF/1/3790-01-01. The work of SDM is funded, in part, by NSF award DBI-1458443. ; Sí

Con questo lavoro, ho cercato di raccontare in che modo il movimento gay, lesbico, bisessuale e transessuale italiano ha contribuito a rendere la nostra società più laica, libertaria e nonviolenta. Per farlo, ho analizzato i tre aspetti principali che ne hanno caratterizzato l'agire: - la difesa della laicità dello Stato - La tutela e l'ampliamento delle libertà individuali - E, soprattutto, il carattere nonviolento delle lotte. La tesi si compone di sette capitoli. In quello iniziale, mi sono occupato delle origini del movimento glbt. Le prime notizie riguardanti l'attivismo politico della comunità glbt, arrivano da Firenze. Nel 1512, un gruppo di trenta giovani aristocratici, riuniti sotto il nome di Compagnacci, fece irruzione nel palazzo del governo, costringendo un alto funzionario alle dimissioni e chiedendo che il consiglio comunale abrogasse le condanne di quei sodomiti che erano stati costretti all'esilio o a cui era stato fatto perdere il posto di lavoro a causa della loro omosessualità. Nel 1432, infatti, era stato creato un corpo di guardie speciali (gli ufficiali di notte), incaricate di occuparsi delle accuse, delle prove e dei processi riguardanti i casi di sodomia. Le denunce contro gli omosessuali venivano presentate anonimamente, infilate in apposite cassette sparse per la città. Una delle vittime più illustri di questo sistema fu Leonardo Da vinci, il quale intratteneva una relazione con il giovane Jacopo Santarelli. Anche a Lucca, nel 1448, fu istituita una magistratura simile. Facendo un salto avanti nel tempo, arriviamo all'avvento del fascismo e notiamo che, rispetto al nazismo, viene adottata una strategia diversa contro i gay. Mentre in Germania, sulla base del paragrafo 175 del codice penale (che prevedeva il carcere per gli atti sessuali tra maschi), il nazismo fece arrestare e deportare nei campi di concentramento circa trentamila omosessuali, in Italia fu deciso in un primo tempo (nel 1936, sulla base delle leggi razziali) di prevedere la misura del confino per i gay, in quanto "nemici della razza". Tre anni dopo, però, ci fu un ripensamento, dovuto alla considerazione che perseguitare un gruppo sociale in quanto gruppo, richiedeva che lo si riconoscesse come tale. Quindi l'omosessualità venne depenalizzata non per indulgenza, ma per dimostrare che gli omosessuali non esistevano: gli italiani erano troppo virili per esserlo. Il controllo e la repressione di questo "problema" fu lasciato alla Chiesa cattolica: un sistema più efficace e meno costoso. Nel secondo capitolo ho illustrato come e quando il movimento glbt si è manifestato come gruppo politico. A livello internazionale, la realtà glbt appare per la prima volta in America, in un locale gay di New York (il bar Stonewall, nel Greenwich village), nella notte del 28 giugno 1969. E' lì che prende avvio "la rivolta di Stonewall", ricordata ogni anno in tutto il mondo con i cortei del Pride. Cosa accade? Per la prima volta, gay, lesbiche e trans decidono di ribellarsi ai soprusi della polizia, che frequentemente faceva irruzione nel locale picchiando e schedando i presenti. La rivolta fu generata dal gesto di una diciassettenne transessuale, Silvia Rivera: il lancio di una scarpa col tacco contro uno dei poliziotti. L'uso di quell'"arma" impropria, è l'emblema del carattere atipico e nonviolento che, fin dalle origini, ha caratterizzato l'agire del movimento glbt. In Italia, sulla scia della rivolta di Stonewall, si verificò la prima uscita pubblica del movimento glbt. Era l'aprile del 1972, e a San Remo il Centro Italiano di sessuologia, un organismo di ispirazione cattolica, aveva organizzato un congresso internazionale sulle devianze sessuali, inserendo nel programma una tavola rotonda e molti interventi specificamente dedicati a cause e terapie dell'omosessualità. Il timore di gay e lesbiche era che l'iniziativa servisse a promuovere un disegno di legge contro l'omosessualità, così com'era già accaduto in Spagna, dove la dittatura franchista, nel 1970, aveva prescritto l'obbligo di cura per questo tipo di "malati" attraverso l'internamento in apposite strutture. Così, la mattina del 5 aprile 1972, organizzarono una clamorosa e inedita contestazione, chiedendo aiuto anche a gruppi glbt di altri paesi. Una protesta decisa, ma allo stesso tempo ironica e gioiosa, per dimostrare che anche nel nostro paese si doveva e poteva lottare a viso aperto contro l'omofobia. Il capitolo 3, è dedicato al rapporto tra movimento glbt e nonviolenza. Secondo lo storico e attivista gay Giovanni dall'Orto, il movimento glbt ha scelto di adottare il metodo di lotta nonviolento "per convinzione, non per debolezza". Ho cercato di dimostrare la veridicità di questa affermazione, raccontando alcuni episodi concreti, ed analizzando il rapporto tra il movimento glbt e il movimento delle donne. Con le femministe, il mondo omosessuale ha condiviso la sperimentazione di pratiche e linguaggi nuovi, alternativi rispetto ai metodi di lotta politica tipici degli anni '70 (ma purtroppo in voga ancora oggi) caratterizzati dal ricorso all'uso della forza, allo scontro fisico e ad un lessico preso in prestito dal mondo militare. L'intento comune era di cambiare una società sessuofobica, fondata sul dominio del maschio, sul familismo e sulla morale cattolica. Nel corso degli anni, il movimento glbt ha avuto più di un'occasione per dimostrare che il proprio agire politico è basato interamente sul pensiero e sul metodo nonviolento. Ad esempio, A Padova, nel 2002, alla vigilia del Pride, gli organizzatori si trovarono stretti da specie di tenaglia: da un lato l'organizzazione di estrema destra "Forza Nuova", annunciava una contromanifestazione; dall'altro, i Disobbedienti del nord est, ribattevano che avrebbero impedito quel corteo. Gli esponenti del Pride, si liberarono da quella morsa esprimendo pubblicamente il rifiuto della comunità glbt di indossare l'elmetto e guerreggiare:"Ogni tentativo di arruolarci nella logica maschilista della violenza è sempre fallita. La violenza è l'arma dei nostri avversari, del maschio fallocratico, dell'esercito. Noi siamo l'alternativa a questo modo di essere e di pensare. Noi siamo l'altro mondo che è possibile. Un altro mondo in cui non sarà più la violenza a dettare legge, ma la nonviolenza, la ragione e le ragioni degli esseri umani". Viene espressa in questo modo la convinzione che per perseguire fini giusti, sia necessario adottare mezzi giusti, ossia nonviolenti. Nella storia dell'umanità, invece, si è costantemente trascurato questo rapporto tra mezzi e fini, con la conseguenza che anche certe rivoluzioni, nate per affermare ideali di libertà e giustizia, si sono trasformate in nuovi dispotismi. Nel capitolo 4 ho descritto come sono nate, in quale contesto storico, e come operano le principali associazioni glbt italiane: Arcigay, Arcilesbica e Movimento di Identità transessuale (Mit). L'ultima parte del capitolo, è dedicata invece ai gruppi glbt di Movimento, aventi posizioni più radicali rispetto alla politica dei "piccoli passi" portata avanti da Arcigay. Queste associazioni, presero parte nel 2001 al contro vertice del G8 a Genova e, l'anno seguente, alle manifestazioni contro la guerra in Iraq e al Social Forum Europeo di Firenze, dando vita (insieme a numerose sigle glbt europee) al workshop"Gay, lesbiche, trans e neoliberismo". Da quest'ultimo scaturirono critiche dure e articolate al modello liberista di sviluppo e di società, e la netta opposizione ad ogni guerra, dato che "non c'è differenza tra intervento in Iraq, in Jugoslavia, in Cecenia, quando si sia in grado di vederne le cause reali e gli effetti, che sono sempre morte e distruzione". Nel documento conclusivo, è resa palese la convinzione che la costruzione di "un altro mondo possibile" passa per l'unione di quanti contestano il modello attuale di società: un'aggregazione tra diversi che oltre ad aumentare la forza della lotta favorisce, allo stesso tempo, un interscambio continuo. Il capitolo 5 è dedicato alla soggettività transessuale. Ho cercato di spiegare i concetti di transessualità e di identità di genere, e di illustrare il percorso (molto lungo e impervio, stabilito dalla legge 164/1982), che una persona transessuale deve affrontare per ottenere l'autorizzazione a modificare i propri dati anagrafici in relazione al sesso prescelto. In Italia, a differenza di altri paesi europei, la giurisprudenza maggioritaria non ammette la rettifica dei dati anagrafici (nome e sesso), in assenza dell'intervento di riattribuzione sessuale. Ciò significa che per anni, una persona che ha assunto di fatto i caratteri tipici di una donna, è costretta ad esibire documenti che la presentano come uomo. Sono molti i casi di transfobia (in questo capitolo ho raccontato quelli originati e alimentati dai mass media), che spesso hanno un epilogo tragico: nel periodo 2008-2013, nel nostro paese le trans uccise sono state ventisei, un numero decisamente superiore a quello delle altre nazioni europee, e che fa dell'Italia il secondo paese per numero di vittime in Europa dopo la Turchia. Nel capitolo 6 mi sono concentrato sul World Pride di Roma del 2000, un caso che dimostra la capacità del movimento glbt di sperimentare e di trascendere i conflitti con grande creatività Nonostante fosse stata programmata e annunciata quattro anni prima, la manifestazione rischiò di essere vietata (o fortemente ridimensionata), a causa della concomitanza con il Giubileo della Chiesa cattolica. Il Presidente del Consiglio dell'epoca, Giuliano Amato, intervenendo sul tema nel corso di una seduta della Camera dei Deputati, disse: "purtroppo c'è la Costituzione, che impone vincoli e costituisce diritti", ma vi è il proposito del Governo di "limitare la manifestazione ad un luogo definito, di isolarla dal resto della città". Una precisazione che non soddisfò il cardinale Camillo Ruini, Presidente della conferenza episcopale italiana, che sottolineò: "La nostra richiesta continua ad essere che questa manifestazione non si faccia. Se non verrà accolta saremo dispiaciuti e adombrati". Il contesto era tutt'altro che favorevole, ma il movimento glbt riuscì a entrare in empatia con l'opinione pubblica e a suscitare sostegni significativi. Amos Luzzato, ad esempio, all'epoca presidente dell'Unione delle comunità ebraiche, affermò:"a una frazione minoritaria del paese, da sempre oggetto di discriminazione oggi si contesterebbe il diritto di organizzare, come qualsiasi altro gruppo, una manifestazione nei tempi e nei luoghi prescelti, nel rispetto della Costituzione e delle leggi dello Stato. Esprimiamo la nostra comprensione e solidarietà per questo gruppo umano(.). Nei campi di sterminio (noi con il triangolo giallo, loro con il triangolo rosa), hanno sofferto insieme a noi e con noi quell'indicibile orrore. Sottolineiamo come il rispetto delle minoranze sia sempre stato e e sia oggi più che mai un segnale e una misura dello stato di salute e della democrazia di una società civile". L'8 luglio del 2000, il corteo che si snodò per le vie di Roma, divenne (e lo è ancora oggi, a distanza di 14 anni) il Pride più partecipato che si sia mai svolto in Italia. Come ebbe modo di scrivere Natalia Aspesi su "La Repubblica" "Duecentomila, un milione, non ha importanza. Perché la folla era comunque immensa, e l'aria era quella di una grande festa di fratellanza, di un oceanico e colorato gioco di solidarietà, di un gigantesco raduno familiare"

COVID-STORM Clinicians Giuseppe Foti1, Giacomo Bellani 1, Giuseppe Citerio1, Ernesto Contro1, Alberto Pesci2, Maria Grazia Valsecchi3, Marina Cazzaniga4 1Department of Emergency, Anesthesia and Intensive Care, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 2Department of Pneumology, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 3Center of Bioinformatics and Biostatistics, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 4Phase I Research Center, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT ; COVID Clinicians Jorge Abad1, Sergio Aguilera-Albesa2, Ozge Metin Akcan3, Ilad Alavi Darazam4, Juan C. Aldave5, Miquel Alfonso Ramos6, Seyed Alireza Nadji7, Gulsum Alkan8, Jerome Allardet-Servent9, Luis M. Allende10, Laia Alsina11, Marie-Alexandra Alyanakian12, Blanca Amador-Borrero13, Zahir Amoura14, Arnau Antolí15, Sevket Arslan16, Sophie Assant17, Terese Auguet18, Axelle Azot19, Fanny Bajolle20, Aurélie Baldolli21, Maite Ballester22, Hagit Baris Feldman23, Benoit Barrou24, Alexandra Beurton25, Agurtzane Bilbao26, Geraldine Blanchard-Rohner27, Ignacio Blanco1, Adeline Blandinières28, Daniel Blazquez-Gamero29, Marketa Bloomfield30, Mireia Bolivar-Prados31, Raphael Borie32, Cédric Bosteels33, Ahmed A. Bousfiha34, Claire Bouvattier35, Oksana Boyarchuk36, Maria Rita P. Bueno37, Jacinta Bustamante20, Juan José Cáceres Agra38, Semra Calimli39, Ruggero Capra40, Maria Carrabba41, Carlos Casasnovas42, Marion Caseris43, Martin Castelle44, Francesco Castelli45, Martín Castillo de Vera46, Mateus V. Castro37, Emilie Catherinot47, Martin Chalumeau48, Bruno Charbit49, Matthew P. Cheng50, Père Clavé31, Bonaventura Clotet51, Anna Codina52, Fatih Colkesen53, Fatma Çölkesen54, Roger Colobran55, Cloé Comarmond56, David Dalmau57, David Ross Darley58, Nicolas Dauby59, Stéphane Dauger60, Loic de Pontual61, Amin Dehban62, Geoffroy Delplancq63, Alexandre Demoule64, Jean-Luc Diehl65, Stephanie Dobbelaere66, Sophie Durand67, Waleed Eldars68, Mohamed Elgamal69, Marwa H. Elnagdy70, Melike Emiroglu71, Emine Hafize Erdeniz72, Selma Erol Aytekin73, Romain Euvrard74, Recep Evcen75, Giovanna Fabio41, Laurence Faivre76, Antonin Falck43, Muriel Fartoukh77, Morgane Faure78, Miguel Fernandez Arquero79, Carlos Flores80, Bruno Francois81, Victoria Fumadó82, Francesca Fusco83, Blanca Garcia Solis84, Pascale Gaussem85, Juana Gil-Herrera86, Laurent Gilardin87, Monica Girona Alarcon88, Mònica Girona-Alarcón88, Jean-Christophe Goffard89, Funda Gok90, Rafaela González-Montelongo91, Antoine Guerder92, Yahya Gul93, Sukru Nail Guner93, Marta Gut94, Jérôme Hadjadj95, Filomeen Haerynck96, Rabih Halwani97, Lennart Hammarström98, Nevin Hatipoglu99, Elisa Hernandez-Brito100, Cathérine Heijmans101, María Soledad Holanda-Peña102, Juan Pablo Horcajada103, Levi Hoste104, Eric Hoste105, Sami Hraiech106, Linda Humbert107, Alejandro D. Iglesias108, Antonio Íñigo-Campos91, Matthieu Jamme109, María Jesús Arranz110, Iolanda Jordan111, Philippe Jorens112, Fikret Kanat113, Hasan Kapakli114, Iskender Kara115, Adem Karbuz116, Kadriye Kart Yasar117, Sevgi Keles118, Yasemin Kendir Demirkol119, Adam Klocperk120, Zbigniew J. Król121, Paul Kuentz122, Yat Wah M. Kwan123, Jean-Christophe Lagier124, Bart N. Lambrecht33, Yu-Lung Lau125, Fleur Le Bourgeois60, Yee-Sin Leo126, Rafael Leon Lopez127, Daniel Leung125, Michael Levin128, Michael Levy60, Romain Lévy20, Zhi Li49, Agnes Linglart129, Bart Loeys130, José M. Lorenzo-Salazar91, Céline Louapre131, Catherine Lubetzki131, Charles-Edouard Luyt132, David C. Lye133, Davood Mansouri134, Majid Marjani135, Jesus Marquez Pereira136, Andrea Martin137, David Martínez Pueyo138, Javier Martinez-Picado139, Iciar Marzana140, Alexis Mathian14, Larissa R. B. Matos37, Gail V. Matthews141, Julien Mayaux142, Jean-Louis Mège143, Isabelle Melki144, Jean-François Meritet145, Ozge Metin146, Isabelle Meyts147, Mehdi Mezidi148, Isabelle Migeotte149, Maude Millereux150, Tristan Mirault151, Clotilde Mircher67, Mehdi Mirsaeidi152, Abián Montesdeoca Melián153, Antonio Morales Martinez154, Pierre Morange155, Clémence Mordacq107, Guillaume Morelle156, Stéphane Mouly13, Adrián Muñoz-Barrera91, Leslie Naesens157, Cyril Nafati158, João Farela Neves159, Lisa FP. Ng160, Yeray Novoa Medina161, Esmeralda Nuñez Cuadros162, J. Gonzalo Ocejo-Vinyals163, Zerrin Orbak164, Mehdi Oualha20, Tayfun Özçelik165, Qiang Pan-Hammarström166, Christophe Parizot142, Tiffany Pascreau167, Estela Paz-Artal168, Sandra Pellegrini49, Rebeca Pérez de Diego84, Aurélien Philippe169, Quentin Philippot77, Laura Planas-Serra170, Dominique Ploin171, Julien Poissy172, Géraldine Poncelet43, Marie Pouletty173, Paul Quentric142, Didier Raoult143, Anne-Sophie Rebillat67, Ismail Reisli174, Pilar Ricart175, Jean-Christophe Richard176, Nadia Rivet28, Jacques G. Rivière177, Gemma Rocamora Blanch15, Carlos Rodrigo1, Carlos Rodriguez-Gallego178, Agustí Rodríguez-Palmero179, Carolina Soledad Romero180, Anya Rothenbuhler181, Flore Rozenberg182, Maria Yolanda Ruiz del Prado183, Joan Sabater Riera15, Oliver Sanchez184, Silvia Sánchez-Ramón185, Agatha Schluter170, Matthieu Schmidt186, Cyril E. Schweitzer187, Francesco Scolari188, Anna Sediva189, Luis M. Seijo190, Damien Sene13, Sevtap Senoglu117, Mikko R. J. Seppänen191, Alex Serra Ilovich192, Mohammad Shahrooei62, Hans Slabbynck193, David M. Smadja194, Ali Sobh195, Xavier Solanich Moreno15, Jordi Solé-Violán196, Catherine Soler197, Pere Soler-Palacín137, Yuri Stepanovskiy198, Annabelle Stoclin199, Fabio Taccone149, Yacine Tandjaoui-Lambiotte200, Jean-Luc Taupin201, Simon J. Tavernier202, Benjamin Terrier203, Caroline Thumerelle107, Gabriele Tomasoni204, Julie Toubiana48, Josep Trenado Alvarez205, Sophie Trouillet-Assant206, Jesús Troya207, Alessandra Tucci208, Matilde Valeria Ursini‬83, Yurdagul Uzunhan209, Pierre Vabres210, Juan Valencia-Ramos211, Eva Van Braeckel33, Stijn Van de Velde212, Ana Maria Van Den Rym84, Jens Van Praet213, Isabelle Vandernoot214, Hulya Vatansev215, Valentina Vélez-Santamaria42, Sébastien Viel171, Cédric Vilain216, Marie E. Vilaire67, Audrey Vincent35, Guillaume Voiriot217, Fanny Vuotto107, Alper Yosunkaya90, Barnaby E. Young126, Fatih Yucel218, Faiez Zannad219, Mayana Zatz37, Alexandre Belot220* ; Imagine COVID Group Christine Bole-Feysot, Stanislas Lyonnet*, Cécile Masson, Patrick Nitschke, Aurore Pouliet, Yoann Schmitt, Frederic Tores, Mohammed Zarhrate Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France. *Leader of the Imagine COVID Group. ; French COVID Cohort Study Group Laurent Abel1, Claire Andrejak2, François Angoulvant3, Delphine Bachelet4, Romain Basmaci5, Sylvie Behillil6, Marine Beluze7, Dehbia Benkerrou8, Krishna Bhavsar4, François Bompart9, Lila Bouadma4, Maude Bouscambert10, Mireille Caralp11, Minerva Cervantes-Gonzalez12, Anissa Chair4, Alexandra Coelho13, Camille Couffignal4, Sandrine Couffin-Cadiergues14, Eric D'Ortenzio12, Charlene Da Silveira4, Marie-Pierre Debray4, Dominique Deplanque15, Diane Descamps16, Mathilde Desvallées17, Alpha Diallo18, Alphonsine Diouf13, Céline Dorival8, François Dubos19, Xavier Duval4, Philippine Eloy4, Vincent VE Enouf20, Hélène Esperou21, Marina Esposito-Farese4, Manuel Etienne22, Nadia Ettalhaoui4, Nathalie Gault4, Alexandre Gaymard10, Jade Ghosn4, Tristan Gigante23, Isabelle Gorenne4, Jérémie Guedj24, Alexandre Hoctin13, Isabelle Hoffmann4, Salma Jaafoura21, Ouifiya Kafif4, Florentia Kaguelidou25, Sabina Kali4, Antoine Khalil4, Coralie Khan17, Cédric Laouénan4, Samira Laribi4, Minh Le4, Quentin Le Hingrat4, Soizic Le Mestre18, Hervé Le Nagard24, François-Xavier Lescure4, Yves Lévy26, Claire Levy-Marchal27, Bruno Lina10, Guillaume Lingas24, Jean Christophe Lucet4, Denis Malvy28, Marina Mambert13, France Mentré4, Noémie Mercier18, Amina Meziane8, Hugo Mouquet20, Jimmy Mullaert4, Nadège Neant24, Marion Noret29, Justine Pages30, Aurélie Papadopoulos21, Christelle Paul18, Nathan Peiffer-Smadja4, Ventzislava Petrov-Sanchez18, Gilles Peytavin4, Olivier Picone31, Oriane Puéchal12, Manuel Rosa-Calatrava10, Bénédicte Rossignol23, Patrick Rossignol32, Carine Roy4, Marion Schneider4, Caroline Semaille12, Nassima Si Mohammed4, Lysa Tagherset4, Coralie Tardivon4, Marie-Capucine Tellier4, François Téoulé8, Olivier Terrier10, Jean-François Timsit4, Théo Trioux4, Christelle Tual33, Sarah Tubiana4, Sylvie van der Werf34, Noémie Vanel35, Aurélie Veislinger33, Benoit Visseaux16, Aurélie Wiedemann26, Yazdan Yazdanpanah36 1Inserm UMR 1163, Paris, France. 2CHU Amiens, France. 3Hôpital Necker, Paris, France. 4Hôpital Bichat, Paris, France. 5Hôpital Louis Mourrier, Colombes, France. 6Institut Pasteur, Paris, France. 7F-CRIN Partners Platform, AP-HP, Université de Paris, Paris, France. 8Inserm UMR 1136, Paris, France. 9Drugs for Neglected Diseases Initiative, Geneva, Switzerland. 10Inserm UMR 1111, Lyon, France. 11Inserm Transfert, Paris, France. 12REACTing, Paris, France. 13Inserm UMR 1018, Paris, France. 14Inserm, Pôle Recherche Clinique, Paris, France. 15CIC 1403 Inserm-CHU Lille, Paris, France. 16Université de Paris, IAME, INSERM UMR 1137, AP-HP, University Hospital Bichat Claude Bernard, Virology, Paris, France. 17Inserm UMR 1219, Bordeaux, France. 18ANRS, Paris, France. 19CHU Lille, Lille, France. 20Pasteur Institute, Paris, France. 21Inserm sponsor, Paris, France. 22CHU Rouen–SMIT, Rouen, France. 23FCRIN INI-CRCT, Nancy, France. 24Inserm UMR 1137, Paris, France. 25Centre d'Investigation Clinique, Inserm CIC1426, Hôpital Robert Debré, Paris, France. 26Inserm UMR 955, Créteil, France; Vaccine Research Instiute (VRI), Paris, France. 27F-CRIN INI-CRCT, Paris, France. 28CHU de Bordeaux–SMIT, Bordeaux, France. 29RENARCI, Annecy, France. 30Hôpital Robert Debré, Paris, France. 31Hôpital Louis Mourier–Gynécologie, Colombes, France. 32University of Lorraine, Plurithematic Clinical Investigation Centre Inserm CIC-P; 1433, Inserm U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France. 33Inserm CIC-1414, Rennes, France. 34Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 35Hôpital la Timone, Marseille, France. 36Bichat–SMIT, Paris, France. ; CoV-Contact Cohort Loubna Alavoine1, Karine K. A. Amat2, Sylvie Behillil3, Julia Bielicki4, Patricia Bruijning5, Charles Burdet6, Eric Caumes7, Charlotte Charpentier8, Bruno Coignard9, Yolande Costa1, Sandrine Couffin-Cadiergues10, Florence Damond8, Aline Dechanet11, Christelle Delmas10, Diane Descamps8, Xavier Duval1, Jean-Luc Ecobichon1, Vincent Enouf3, Hélène Espérou10, Wahiba Frezouls1, Nadhira Houhou11, Emila Ilic-Habensus1, Ouifiya Kafif11, John Kikoine11, Quentin Le Hingrat8, David Lebeaux12, Anne Leclercq1, Jonathan Lehacaut1, Sophie Letrou1, Bruno Lina13, Jean-Christophe Lucet14, Denis Malvy15, Pauline Manchon11, Milica Mandic1, Mohamed Meghadecha16, Justina Motiejunaite17, Mariama Nouroudine1, Valentine Piquard11, Andreea Postolache11, Caroline Quintin1, Jade Rexach1, Layidé Roufai10, Zaven Terzian11, Michael Thy18, Sarah Tubiana1, Sylvie van der Werf3, Valérie Vignali1, Benoit Visseaux8, Yazdan Yazdanpanah14 1Centre d'Investigation Clinique, Inserm CIC 1425, Hôpital Bichat Claude Bernard, APHP, Paris, France. 2IMEA Fondation Léon M'Ba, Paris, France. 3Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 4University of Basel Children's Hospital. 5Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands. 6Université de Paris, IAME, Inserm UMR 1137, F-75018, Paris, France, Hôpital Bichat Claude Bernard, APHP, Paris, France. 7Hôpital Pitiè Salpétriere, APHP, Paris. 8Université de Paris, IAME, INSERM UMR 1137, AP-HP, University Hospital Bichat Claude Bernard, Virology, Paris, France. 9Santé Publique France, Saint Maurice, France. 10Pole Recherche Clinique, Inserm, Paris, France. 11Hôpital Bichat Claude Bernard, APHP, Paris, France. 12APHP, Paris, France. 13Virpath Laboratory, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France. 14IAME Inserm UMR 1138, Hôpital Bichat Claude Bernard, APHP, Paris, France. 15Service des Maladies Infectieuses et Tropicales; Groupe Pellegrin-Place Amélie-Raba-Léon, Bordeaux, France. 16Hôpital Hotel Dieu, APHP, Paris, France. 17Service des Explorations Fonctionnelles, Hôpital Bichat–Claude Bernard, APHP, Paris, France. 18Center for Clinical Investigation, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France. ; Amsterdam UMC Covid-19 Biobank Michiel van Agtmael1, Anna Geke Algera2, Frank van Baarle2, Diane Bax3, Martijn Beudel4, Harm Jan Bogaard5, Marije Bomers1, Lieuwe Bos2, Michela Botta2, Justin de Brabander6, Godelieve de Bree6, Matthijs C. Brouwer4, Sanne de Bruin2, Marianna Bugiani7, Esther Bulle2, Osoul Chouchane1, Alex Cloherty3, Paul Elbers2, Lucas Fleuren2, Suzanne Geerlings1, Bart Geerts8, Theo Geijtenbeek9, Armand Girbes2, Bram Goorhuis1, Martin P. Grobusch1, Florianne Hafkamp9, Laura Hagens2, Jorg Hamann10, Vanessa Harris1, Robert Hemke11, Sabine M. Hermans1, Leo Heunks2, Markus W. Hollmann8, Janneke Horn2, Joppe W. Hovius1, Menno D. de Jong12, Rutger Koning4, Niels van Mourik2, Jeaninne Nellen1, Frederique Paulus2, Edgar Peters1, Tom van der Poll1, Benedikt Preckel8, Jan M. Prins1, Jorinde Raasveld2, Tom Reijnders1, Michiel Schinkel1, Marcus J. Schultz2, Alex Schuurman13, Kim Sigaloff1, Marry Smit2, Cornelis S. Stijnis1, Willemke Stilma2, Charlotte Teunissen14, Patrick Thoral2, Anissa Tsonas2, Marc van der Valk1, Denise Veelo8, Alexander P.J. Vlaar15, Heder de Vries2, Michèle van Vugt1, W. Joost Wiersinga1, Dorien Wouters16, A. H. (Koos) Zwinderman17, Diederik van de Beek4* 1Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 2Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 3Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 4Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, Netherlands. 5Department of Pulmonology, Amsterdam UMC, Amsterdam, Netherlands. 6Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 7Department of Pathology, Amsterdam UMC, Amsterdam, Netherlands. 8Department of Anesthesiology, Amsterdam UMC, Amsterdam, Netherlands. 9Department of Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 10Amsterdam UMC Biobank Core Facility, Amsterdam UMC, Amsterdam, Netherlands. 11Department of Radiology, Amsterdam UMC, Amsterdam, Netherlands. 12Department of Medical Microbiology, Amsterdam UMC, Amsterdam, Netherlands. 13Department of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands. 14Neurochemical Laboratory, Amsterdam UMC, Amsterdam, Netherlands. 15Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 16Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, Netherlands. 17Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands. 18Department of Neurology, Amsterdam UMC, Amsterdam, Netherlands. *Leader of the AMC Consortium. ; COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryceson12, Carlos D. Bustamante13, Manish Butte14, Giorgio Casari15, Samya Chakravorty16, John Christodoulou17, Elizabeth Cirulli9, Antonio Condino-Neto18, Megan A. Cooper19, Clifton L. Dalgard20, Alessia David21, Joseph L. DeRisi22, Murkesh Desai23, Beth A. Drolet24, Sara Espinosa25, Jacques Fellay26, Carlos Flores27, Jose Luis Franco28, Peter K. Gregersen29, Filomeen Haerynck30, David Hagin31, Rabih Halwani32, Jim Heath33, Sarah E. Henrickson34, Elena Hsieh35, Kohsuke Imai36, Yuval Itan8, Timokratis Karamitros37, Kai Kisand38, Cheng-Lung Ku39, Yu-Lung Lau40, Yun Ling41, Carrie L. Lucas42, Tom Maniatis43, Davoud Mansouri44, Laszlo Marodi45, Isabelle Meyts46, Joshua Milner47, Kristina Mironska48, Trine Mogensen49, Tomohiro Morio50, Lisa FP. Ng51, Luigi D. Notarangelo52, Antonio Novelli53, Giuseppe Novelli54, Cliona O'Farrelly55, Satoshi Okada56, Tayfun Ozcelik57, Rebeca Perez de Diego58, Anna M. Planas59, Carolina Prando60, Aurora Pujol61, Lluis Quintana-Murci62, Laurent Renia63, Alessandra Renieri64, Carlos Rodríguez-Gallego65, Vanessa Sancho-Shimizu66, Vijay Sankaran67, Kelly Schiabor Barrett9, Mohammed Shahrooei68, Andrew Snow69, Pere Soler-Palacín70, András N. Spaan71, Stuart Tangye72, Stuart Turvey73, Furkan Uddin74, Mohammed J. Uddin75, Diederik van de Beek76, Sara E. Vazquez77, Donald C. Vinh78, Horst von Bernuth79, Nicole Washington9, Pawel Zawadzki80, Helen C. Su52, Jean-Laurent Casanova81 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milan, Italy. 3King Saud University, Riyadh, Saudi Arabia. 4Kuwait University, Kuwait City, Kuwait. 5University of California, San Francisco, San Francisco, CA, USA. 6Universidad de Antioquia, Group of Primary Immunodeficiencies, Antioquia, Colombia. 7The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 8Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9Helix, San Mateo, CA, USA. 10Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine. 11Clinical Immunology Unit, Pediatric Infectious Disease Departement, Faculty of Medicine and Pharmacy, Averroes University Hospital; LICIA Laboratoire d'Immunologie Clinique, d'Inflammation et d'Allergie, Hassann Ii University, Casablanca, Morocco. 12Karolinska Institute, Stockholm, Sweden. 13Stanford University, Stanford, CA, USA. 14University of California, Los Angeles, CA, USA. 15Medical Genetics, IRCCS Ospedale San Raffaele, Milan, Italy. 16Emory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, USA. 17Murdoch Children's Research Institute, Victoria, Australia. 18University of São Paulo, São Paulo, Brazil. 19Washington University School of Medicine, St. Louis, MO, USA. 20The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 21Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK. 22University of California, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. 23Bai Jerbai Wadia Hospital for Children, Mumbai, India. 24School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 25Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico. 26Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. 27Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Canarian Health System, Santa Cruz de Tenerife, Spain. 28University of Antioquia, Medellín, Colombia. 29Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, USA. 30Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Edegem, Belgium. 31The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 32Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE. 33Institute for Systems Biology, Seattle, WA, USA. 34Children's Hospital of Philadelphia, Philadelphia, PA, USA. 35Anschutz Medical Campus, Aurora, CO, USA. 36Riken, Tokyo, Japan. 37Hellenic Pasteur Institute, Athens, Greece. 38University of Tartu, Tartu, Estonia. 39Chang Gung University, Taoyuan County, Taiwan. 40The University of Hong Kong, Hong Kong, China. 41Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. 42Yale School of Medicine, New Haven, CT, USA. 43New York Genome Center, New York, NY, USA. 44Shahid Beheshti University of Medical Sciences, Tehran, Iran. 45Semmelweis University Budapest, Budapest, Hungary. 46KU Leuven, Department of Immunology, Microbiology and Transplantation, Leuven, Belgium. 47Columbia University Medical Center, New York, NY, USA. 48University Clinic for Children's Diseases, Skopje, North Macedonia. 49Aarhus University, Aarhus, Denmark. 50Tokyo Medical & Dental University Hospital, Tokyo, Japan. 51Singapore Immunology Network, Singapore. 52National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 53Bambino Gesù Children's Hospital, Rome, Italy. 54Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy. 55Trinity College, Dublin, Ireland. 56Hiroshima University, Hiroshima, Japan. 57Bilkent University, Ankara, Turkey. 58Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain. 59IIBB-CSIC, IDIBAPS, Barcelona, Spain. 60Faculdades Pequeno Príncipe e Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil. 61Neurometabolic Diseases Laboratory, IDIBELL–Hospital Duran I Reynals; Catalan Institution for Research and Advanced Studies (ICREA); CIBERER U759, ISCiii Madrid Spain, Barcelona, Spain. 62Institut Pasteur (CNRS UMR2000) and Collège de France, Paris, France. 63Infectious Diseases Horizontal Technology Center and Singapore Immunology Network, Agency for Science Technology (A*STAR), Singapore. 64Medical Genetics, University of Siena, Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy; GEN-COVID Multicenter Study. 65Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Canary Islands, Spain. 66Imperial College London, London, UK. 67Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 68Saeed Pathobiology and Genetic Lab, Tehran, Iran. 69Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 70Hospital Universitari Vall d'Hebron, Barcelona, Spain. 71University Medical Center Utrecht, Amsterdam, The Netherlands. 72Garvan Institute of Medical Research, Sydney, Australia. 73The University of British Columbia, Vancouver, Canada. 74Holy Family Red Crescent Medical College; Centre for Precision Therapeutics, NeuroGen Children's Healthcare; Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare, Dhaka, Bangladesh. 75Mohammed Bin Rashid University of Medicine and Health Sciences, College of Medicine, Dubai, UAE; The Centre for Applied Genomics, Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. 76Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands. 77University of California, San Francisco, CA, USA. 78McGill University Health Centre, Montreal, Canada. 79Charité–Berlin University Hospital Center, Berlin, Germany. 80Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Uniwersytetu Poznanskiego 2, Poznań, Poland. 81Rockefeller University, Howard Hughes Medical Institute, Necker Hospital, New York, NY, USA. *Leaders of the COVID Human Genetic Effort. ; NIAID-USUHS/TAGC COVID Immunity Group Huie Jing1,2, Wesley Tung1,2, Christopher R. Luthers3, Bradly M. Bauman3, Samantha Shafer2,4, Lixin Zheng2,4, Zinan Zhang2,4, Satoshi Kubo2,4, Samuel D. Chauvin2,4, Kazuyuki Meguro1,2, Elana Shaw1,2, Michael Lenardo2,4, Justin Lack5, Eric Karlins6, Daniel M. Hupalo7, John Rosenberger7, Gauthaman Sukumar7, Matthew D. Wilkerson7, Xijun Zhang7 1Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 2NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. 3Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 4Laboratory of Immune System Biology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 5NIAID Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA. 6Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. 7The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. ; Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection. ; We thank the generous donation from Fisher Center for Alzheimer's Research Foundation for our research. The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the "Investments for the Future" program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project, ANRS-COV05, the Square Foundation, Grandir - Fonds de solidarité pour l'enfance, the SCOR Corporate Foundation for Science, Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Paris. The French COVID Cohort study group was sponsored by Inserm and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). Regione Lombardia, Italy (project "Risposta immune in pazienti con COVID-19 e co-morbidità"), and the Intramural Research Program of the NIAID, NIH. The laboratory of Genomes & Cell Biology of Disease is supported by "Integrative Biology of Emerging Infectious Diseases" (grant no. ANR-10-LABX-62-IBEID), the "Fondation pour la Recherche Medicale" (grant FRM - EQU202003010193), the "Agence Nationale de la Recherche" (ANR FLASH COVID project IDISCOVR cofounded by the "Fondation pour la Recherche Médicale"), University of Paris ("Plan de Soutien Covid-19": RACPL20FIR01-COVID-SOUL). IM is a senior clinical investigator with the FWO Vlaanderen; IM and LM are supported by FWO G0C8517N – GOB5120N. The VS team was supported by "Agence Nationale de la Recherche" (ANR-17-CE15-0003, ANR-17-CE15-0003-01), and by Université de Paris "PLAN D'URGENCE COVID19". LK was supported by a fellowship from the French Ministry of Research. VS-S is supported by a UKRI Future Leaders Fellowship (MR/S032304/1). SZA-M is supported by the Elite Journals Program at King Saud University through grant number PEJP-16-107. JM lab is supported by Columbia University COVID biobank and grant: UL1TR001873. Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1, a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. JLP is supported by a European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018). Work at the Neurometabolic Diseases Laboratory received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 824110 (EasiGenomics grant COVID-19/ PID12342) to A.P., and Roche and Illumina Covid Match Funds to M.G. C.R.G and colleagues are supported by cInstituto de Salud Carlos III (COV20_01333 and COV20_01334), Spanish Ministry of Science and Innovation, with the funding of European Regional Development Fund-European Social Fund -FEDER-FSE; (RTC-2017-6471-1; AEI/FEDER, UE), and Cabildo Insular de Tenerife (CGIEU0000219140 and "Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19"). D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. Helen Su is adjunct faculty at the University of Pennsylvania. A-L.N. was supported by the Foundation Bettencourt Schueller. The Amsterdam UMC Covid-19 Biobank was funded by the Netherlands Organization for Health Research and Development (ZonMw, NWO-vici 91819627), The Corona Research Fund (Amsterdam UMC), Dr. J. C. Vaillantfonds, and Amsterdam UMC. Work on COVID-19 at the AG-S lab is partly supported by NIH supplements to grants U19AI135972, U19AI142733 and R35 HL135834, and to contract HHSN272201800048C, by a DoD supplement to grant W81XWH-20-1-0270, by DARPA project HR0011-19-2-0020, by CRIP (Center for Research on Influenza Pathogenesis), a NIAID funded Center of Excellence for Influenza Research and Surveillance (CEIRS, contract HHSN272201400008C), by an NIAID funded Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC, contract 75N93019C00051) and by the generous support of the JPB Foundation, the Open Philanthropy Project (research grant 2020-215611(5384)) and anonymous donors. The Virscan analysis presented in fig. S11 was performed with financial support from Sidra Medicine ; Peer reviewed

KUPFERSTICH UND HOLZSCHNITT IN VIER JAHRHUNDERTEN Kupferstich und Holzschnitt in vier Jahrhunderten ( - ) Einband ( - ) Titelseite ([III]) Impressum ([IV]) Vorwort. ([V]) [Abb.]: ([V]) Inhaltsverzeichnis ([IX]) Einleitung. Die Technik des Bilddruckes (1) [Abb.]: (1) Das fünfzehnte Jahrhundert ([13]) Der Holzschnitt in Deutschland ([15]) [Abb.]: ([15]) [Abb.]: Die Ruhe auf der Flucht nach Ägypten. Wien, Staatsbibliothek. Original: 184x212 mm. ([27]) [Abb.]: Blatt aus der Biblia pauperum. Heidelberg. Universitäts-Bibliothek. Original: 220x177 mm. (34) [Abb.]: Aus dem Eunuchen des Terenz. Ulm, Konrad, 1486. ([42]) [Abb.]: Aus Sebastian Brants Narrenschiff. Basel, Bergman von Olpe 1494. (44) [Abb.]: Aus: Boethius. De Consolatione philosophica. Straßburg, Grüninger, 1501. (47) [Abb.]: Aus dem Schatzbehalter. Nürnberg, Koburger 1491. Ausschnitt. ([49]) [Abb.]: Aus der Bibel. Lübeck, Stephen Arndes 1494. Ausschnitt. (51) [Abb.]: Aus Breydenbachs peregrinationes ad sepulcrum Christi. Mainz, 1486. (52) [Abb.]: Die Kreuzigung. Schrotblatt. Schreiber 2341. Berlin, Kupferstichkabinett. ([55]) [Abb.]: Leiste aus dem Plenarium. Straßburg, Schott 1483. Original 165 mm. (56) Der Kupferstich in Deutschland und in den Niederlanden ([57]) [Abb.]: Martin Schongauer. Der Müller mit den Eseln. ([57]) [Abb.]: Meister der Spielkarten, Cyclamendame aus dem Kartenspiel. (60) [Abb.]: Meister E. S. Thronende Madonna mit dem Kinde und Engeln. Lehrs 76. (63) [Abb.]: Martin Schonaguer. Die Verkündigung. ([67]) [Abb.]: Veit Stoss, Madonna mit dem Kinde. ([70]) [Abb.]: Meister des Amstadamer Kabinetts. Die Kreuzigung. (72) [Abb.]: Meister P. P. W., Nelkendame aus dem Kartenspiel. (73) [Abb.]: Meister M. Z., Das Liebespaar. (74) [Abb.]: Meister der Liebesgärten, Ausschnitt aus dem großen Liebesgarten. (76) [Abb.]: Israel von Meckenem, Das Duett. ([77]) [Abb.]: Meister J. A. M. von Zwolle, Ausschnitt aus der Anbetung der Könige. ([78]) [Abb.]: Meister F. V. B., Der h. Antonius Eremita. ([80]) [Abb.]: Allart du Hameel, Nach Hieronymus Bosch, Das jüngste Gericht. Ausschnitt. (81) [Abb.]: Martin Schongauer. Greif. Kupferstich. (82) Der Holzschnitt in den Niederlanden ([83]) [Abb.]: Aus dem Dialogus Creaturarum. Gouda, Gerhard Leu, 1480. ([83]) [Abb.]: Aus er ältesten Barockausgabe der Apokalypse (Ausschnitt). (85) [Abb.]: Blatt der Biblia pauperum (Schreiber IV. Ausgabe) Original 266x192 mm. ([88]) [Abb.]: Aus dem Speculum humanae salvationis. (92) [Abb.]: Blatt aus der Editio princeps der Ars Moriendi. Original 216x156 mm. ([94]) [Abb.]: Madonna mit dem Kinde in der Glorie. Berlin, Kupferstichkabinett. Original 348x258 mm. ([97]) [Abb.]: Aus dem Belial des Jacobus de Theramo. Haarelm, Jacob Bellart, 1484. (99) [Abb.]: Aus Ludolphus de Saxonia, Boeck van den leven ons heeren. Antwerpen, Gerard Leu, 1487. (101) [Abb.]: Aus dem Chavalier délibéré. Gouda, Gottfried van Os. 1486. ([103]) [Abb.]: Aus der Historie hertoghe Godevaerts van Boloen. Gouda 1485 (oder 86). (104) Der Holzschnitt in Frankreich ([105]) [Abb.]: Aus der Danse Macabre. Paris, Guy Marchant. 1499. ([105]) [Abb.]: Aus La Mer des histoires. Paris, Le Rouge, 1488/89. (109) [Abb.]: Aus L'Art de bien vivre et de bien mourir. Paris, A. Vérard, 1492. (110) [Abb.]: Livre d'heures Paris, S. Vostre, 1496. (112) [Abb.]: Aus den Heures à l'usage de Rome. Paris, Ph. Pigouchet pour S. Vostre. ([113]) [Abb.]: Aus den Komödien des Terenz. Lyon, Johannes Trechsel, 1493. (116) [Abb.]: (117) Der Holzschnitt in England. ([118]) [Abb.]: ([118]) [Abb.]: (121) Der Holzschnitt in Spanien. (121) [Abb.]: (126) Der Holzschnitt in Italien. ([127]) [Abb.]: Aus der Biblia cum postillis Nocolai de Lyra. Venedig, 1489. ([127]) [Abb.]: Aus dem venezianischen Blockbuche, die Passion Christi, im Kupferstichkabinett zu Berlin. Original: 220x145 mm. ([129]) [Abb.]: Aus: Valturius, de re militari. Verona, 1472. (132) [Abb.]: Aus der Malermi-Bibel. Venedig 1490. (135) [Abb.]: Aus der italienischen Bibel, Venedig, G. de Tridino 1493. (137) [Abb.]: Aus der Hypnerotomachia Polifili, Venedig, Aldus, 1499. (141) [Abb.]: Aus dem Missale Romanum, Venedig, B. Stagninus, 1506. (144) [Abb.]: Bildnis der Trivulzia. Aus Foresti, de claris mulieribus, Ferrara, 1497. (148) [Abb.]: Aus dem Laude devote did diversi autori. Florenz. (158) [Abb.]: Aus Savonarolas Compendio di rivelazione. 1496. Pacini. (160) [Abb.]: Aus Pulcis Morgante maggiore. 1500 P. Pacini. (161) [Abb.]: Aus dem Äsop, Neapel, Francesco Tuppo 1485. (167) Der Kupferstich in Italien. ([169]) [Abb.]: ([169]) [Abb.]: Unbekannter Florentiner Stecher. Bildnis einer Dame. Berlin, Kupferstichkabinett. ([171]) [Abb.]: Amor. Nielloabdruck. (173) [Abb.]: Unbekannter Florentiner Stecher. Der Triumph der Zeit. Ausschnitt. ([177]) [Abb.]: Unbekannter Florentiner Stecher. Der Prophet Samuel. ([179]) [Abb.]: Christofano Robetta. Zwei Musen. Nach Filippino Lippi. (Oben ein Stück abgeschnitten.) ([181]) [Abb.]: Unbekannter venezianischer Stecher. Blatt aus der Folge Tarocchi. ([183]) [Abb.]: Andrea Mantegna. Die Grablegung. Ausschnitt. (187) [Abb.]: Nicoletto da Modena. Der h. Antonius der Eremit. (189) [Abb.]: Benedetto Montagna. Der h. Hieronymus. Ausschnitt. (191) [Abb.]: Giulio Campagnola. Christus und die Samariterin. ([193]) [Abb.]: Jacopo de' barbari. Der h. Hieronymus. (194) [Abb.]: Bologneser Meister. Tobias mit dem Engel. (198) [Abb.]: Meister J. B. mit dem Vogel. Satyrweibchen. (199) [Abb.]: ([200]) Das sechzehnte Jahrhundert ([201]) Holzschnitt und Kupferstich in deutschland. ([203]) [Abb.]: Albrecht Dürer. Der Schmerzensmann. ([203]) [Abb.]: Albrecht Dürer. Der Liebeshandel. (205) [Abb.]: Albrecht Dürer. Madonna auf dem Halbmond. (206) [Abb.]: Albrecht Dürer. Aus der Apokalypse. B. 69. Wenig verkleinert. ([208]) [Abb.]: Albrecht Dürer. Der heilige Georg zu Pferde. (210) [Abb.]: Albrecht Dürer. Petrus und Johannes den Lahmen heilend. (212) [Abb.]: Albrecht Dürer. Der heilige Antonius der Eremit. (213) [Abb.]: Albrecht Dürer. Der Dudelsackpfeifer. (214) [Abb.]: Albrecht Dürer. Bildnis des Philippus Melanchthon. ([215]) [Abb.]: Albrecht Dürer. Die Fußwaschung. Aus der kleinen Passion. B. 25. (217) [Abb.]: Albrecht Dürer. Die Herodias empfängt das Haupt des Täufers. ([219]) [Abb.]: Albrecht Dürer. Bildnis des Eobanus Hessus. (220) [Abb.]: Hans Burgkmair. Bathseba. (223) [Abb.]: Hans Weiditz. Kaiser Maximilian die Messe hörend. Ausschnitt. (224) [Abb.]: Meister mit dem zeichen D. S. Das selige und das reuelose Sterben. (225) [Abb.]: Hans Baldung Grien. Der heilige Sebastian. (227) [Abb.]: Hans Holbein d. J. Der heilige Paulus. (231) [Abb.]: Hans Holbein d. J. Aus den Bibelbildern. (232) [Abb.]: Hans Holbein d. J. Aus dem Totentanz. (233) [Abb.]: Lucas Cranach. Christus und die Samariterin. Original 230x160. ([236]) [Abb.]: Albrecht Altdorfer. Das Liebespaar im Walde. (239) [Abb.]: Albrecht Altdorfer. Die h. Familie. (241) [Abb.]: Bartel Beham. Die Madonna am Fenster. (243) [Abb.]: Hans Seebald Beham. Bauerngesellschaft. B. 164. (244) [Abb.]: Hans Sebald Beham. Kains Brudermord. (245) [Abb.]: Meister J. B. Kampf nackter Männer. (246) [Abb.]: Heinrich Aldegrever. Aus der Folge der Hochzeitstänzer. B. 164. (248) [Abb.]: Augustin Hirschvogel. Landschaft B. 66. ([251]) [Abb.]: Virgil Solis. Judith. (253) [Abb.]: Tobias Stimmer. Bildnis des Stephan Brechtel. ([255]) Der Kupferstich in Italien. ([258]) [Abb.]: Marcantonio Raimondi. Allegorische darstellung. B. 356. ([258]) [Abb.]: Marcantonio Raimondi. Allegorische Darstellung. B. 377. (261) [Abb.]: Marcantonio Raimondi. Lucretia. ([264]) [Abb.]: Marcantonio Raimondi. Jupiter Amor küssend. Ausschnitt. (267) [Abb.]: Giorgio Ghisi. Der Sieg. Obere Hälfte. (273) [Abb.]: Francesco Parmigianino. Die Annunciata. (275) [Abb.]: Federico Barocci. Madonna mit dem Kinde in Wolken. ([278]) [Abb.]: Annibale Carracci. Il Cristo di Caprarola. ([280]) [Abb. Agostino Carracci. Bildnis des Schauspielers Sivel. ([282]) Der Holzschnitt in Italien. ([284]) [Abb.]: ([284]) [Abb.]: Unbekannter venezianischer Meister. Bildnis des Fr. Priscianesi. (285) [Abb.]: Titelbild zu der Anatomie des Andreas Versalius. Basel 1543. Ausschnitt. (289) [Abb.]: Christoforo Coriolano. Bildnis aus Vasaris Vite dei pittori. Florenz 1568. (292) [Abb.]: Ausschnitt aus dem Titelblatte zu Fantis Trionfo dell Fortuna. Venedig 1526. (296) [Abb.]: Domenico Campagnola. Der h. Hieronymus. Ausschnitt. (297) [Abb.]: Nicolò Boldrini, nach Tizian. Venus und Amor. Ausschnitt. (298) [Abb.]: Ugo da Carpi nach Raffael. "Raffael und seine Geliebte". (310) Kupferstich und Holzschnitt in den Niederlanden. ([312]) [Abb.]: Lucas von Leyden. Ornament. ([312]) [Abb.]: Lucas von Leyden. Der h. Christoph. (314) [Abb.]: Lucas von Leyden. Madonna. (316) [Abb.]: Lucas von Leyden. Pallas. (317) [Abb.]: Lucas von Leyden. Abraham führt Isaak zur Opferung. Ausschnitt. ([318]) [Abb.]: Jacob Corneliszen. Die Handwaschung Pilati. (320) [Abb.]: Dirick Vellert. Der Fischzug Petri. (322) [Abb.]: Johannes Wierix. Bildnis Alvin 1851. (324) [Abb.]: Hans Bol. Der Winter (325) [Abb.]: Hendrik Goltzius. Der h. Paulus. B. 56 (328) [Abb.]: Hendrik Goltzius. Landschaft. B. 224. Strichplatte. (329) [Abb.]: (330) Kupferstich und Holzschnitte in Frankreich. ([331]) [Abb.]: Jean Gourmont. Der h. Eligius. ([331]) [Abb.]: Jean Duvet. Judas. Ausschnitt aus dem Blatte B. II. (333) [Abb.]: Geoffroy Tory. Aus dem Livre d'heures, Paris 1531. ([336]) [Abb.]: Jean Cousin. Aus dem Livre perspective. Paris 1560. (339) [Abb.]: Bernard Salomon. Aus dem Quadrins de la Bible. Lyon 1553. (341) [Abb.]: Etienne Delaune. Goldschmiedwerkstatt. (342) [Abb.]: Jaques Androuet Ducerceau. Die Zeichner in den Ruinen. (344) [Abb.]: (445 [345]) Das siebzehnte Jahrhundert ([347]) Kupferstich und Holzschnitt in den Niederlanden. ([349]) [Abb.]: Rembrandt. Selbstbildnis. ([349]) [Abb.]: Lucas Vorsterman nach Rubens. Die Anbetung der Hirten. Ausschnitt (354) [Abb.]: Paulus Pontius nach Rubens. Thomyris. Ausschnitt. (356) [Abb.]: Schelte Adams Bolswerth. Ausschnitt aus der Landschaft mit dem Regenbogen. ([357]) [Abb.]: Lucas van Uden. Landschaft B. 6. (361) [Abb.]: Antonius van Dyck. Selbstbildnis W. 4, I. (362) [Abb.]: Christoph Jegher nach Rubens. Christus und der Johannesknabe. Ausschnitt von 225x140 mm. Originalgröße. (364) [Abb.]: Jonas Suyderhoef nach Frans Hals. Bildnis des Wickenburg. Ausschnitt. (365) [Abb.]: Cornelis Visscher. Bildnis des Justus Vondeel. Ausschnitt. ([367]) [Abb.]: Hendrik van Goudt. Hinrichtung Johannis des Täufers. (368) [Abb.]: Allaert van Everdingen. Landschaft D. 12. (369) [Abb.]: Jacob van Ruisdael. Die Landschaft mit den drei Eichen. (370) [Abb.]: Nicolas Berchem. Die Kuh und Schafe. B. 26. (372) [Abb.]: Paulus Potter. Kopf eines Stiers. B. 15. (374) [Abb.]: Adriaen van Ostade. Der Brillenverkäufer. F. 29. II. (376) [Abb.]: Rembrandt. Der Rattengiftverkäufer. B. 121. (381) [Abb.]: Rembrandt. Joseph seine Träume erzählend. B. 37. (383) [Abb.]: Rembrandt. Die Landschaft mit den beiden Schwänen. B. 235. (386) [Abb.]: Rembrandt. Selbstbildnis. B. 22. II. (389) [Abb.]: Rembrandt. Die Opferung Isaaks. B. 35. (390) [Abb.]: Rembrandt. Christus in Gethsemane. B. 75. (391) [Abb.]: Rembrandt. Männlicher Akt, sitzend. B. 193. ([393]) [Abb.]: Bildnis. B. 61. (396) Der Kupferstich in Italien. ([398]) [Abb.]: Simone Cantarini. Heilige Familie. ([398]) [Abb.]: Guido Reni. Madonna mit dem Kinde. Wenig verkleinert. (400) [Abb.]: Giov. Francesco Barbieri gen. Guercino. Der h. Antonius. (402) [Abb.]: Giuli Carpioni. Kinderbachanal. Ausschnitt, wenig verkleinert. (405) [Abb.]: Giov. Benedetto Castiglioni. Satyrszene. Ausschnitt. (406) [Abb.]: Stefano della Bella. Im Hafen. Jombert 134, I. (410) [Abb.]: Carlo Maratta. Die Verkündigung. Obere Hälfte. (412) [Abb.]: Michelangelo Merisi da Caravaggio. Die Verleugnung Petri. (414) [Abb.]: Giuseppe Ribera. Der Poet. B. 10. ([418]) [Abb.]: Salvator Rosa. Tritonenkampf. B. 12. Wenig verkleinert. (419) Der Kupferstich in Frankreich. ([421]) [Abb.]: Jaques Callot. Aus den Balli de Sfessania. ([421]) [Abb.]: Jaques Callot. Aus den "peites misères de la guerre". Meaume 562. (425) [Abb.]: Claude Lorrain. Der Hafen.R.-D. 15, I. Wenig verkleinert. ([431]) [Abb.]: Claude mellan, Bildnis des Pierre Gassendi. Ausschnitt. (433) [Abb.]: Jean Morin. Bildnis des Jean Pierre Camus. Ausschnitt. (434) [Abb.]: Robert Nanteuil. Bildnis des François. La Vayer. Ausschnitt. (436) [Abb.]: Antoine Masson. Bildnis des Pierre Dupuis. Ausschnitt. ([438]) [Abb.]: Gérard Edelinck. Bildnis des Robert Nanteuil. Ausschnitt. ([441]) [Abb.]: Jean Le Pautre. Einrichtung eines vornehmen Schlafgemaches. Wenig verkleinert. (443) Kupferstich und Holzschnitt in Deutschland ([445]) [Abb.]: Adam Elsheimer. Die tanzende Nymphe. ([445]) [Abb.]: Aegidius Sadeler. Bildnis des Arnold von Reyger. (449) [Abb.]: Jeremias Falck. Bildnis des Predigers Daniel Dilger. Ausschnitt. (451) [Abb.]: Johann Wilhelm Baur. Reiterkampf. Meyer 24. Wenig verkleinert. (455) [Abb.]: Johann Heinrich Roos. Schafe und Ziegen. B. 4. (457) [Abb.]: Wenzel Hollar. Rheinlandschaft. Parthey 702. (459) Die Schabkunst in Deutschland, in den Niederlanden und in England. (460) [Abb.]: Prinz Ruprecht von der Pfalz. Der Kopf des Henkers. Andresen 7. Ausschnitt. (463) [Abb.]: Wallerant Vaillant. Bildnis seines Sohnes. Wessely 15. (464) [Abb.]: James Mac Ardell nach Reynolds. Bildnis der Lady Elizabeth Montague. Ausschnitt. Wenig verkleinert. ([469]) Das achtzehnte Jahrhundert ([471]) Der Kupferstich in Frankreich. ([473]) [Abb.]: Pierre-Philippe Choffard. Vignette aus Ovids Metamorphosen. Paris 1769. ([473]) [Abb.]: Pierre Imbert Drevet. Bildnis der Herzogin von Orléans. (475) [Abb.]: Etienne Ficquet. Bildnis Lafontaines. Faucheux 62. (477) [Abb.]: Nicolas Henri Tardieu nach Wattenau. Die Einschiffung nach Cythera. Ausschnitt. ([481]) [Abb.]: François Boucher. Schlafende Kinder. Baudicour. 3. Wenig verkleinert. ([485]) [Abb.]: Honoré Fragonard. Die beiden Frauen zu Pferde. Baudicour 5. (486) [Abb.]: Richard de Saint-Non nach Le Prince. Landschaft. (488) [Abb.]: Claude Gillot. Aus La Mottes Fables nouvelles. Paris 1719. (496) [Abb.]: Flipart nach H. F. Gravelot. Aus Boccaccios Decamerone, 1757. (499) [Abb.]: Nach Charles Eisen. Der Tausch. Aus Lafontaines Contes et nouvelles. 1762. (500) [Abb.]: Jean Michel Moreau le jeune. La Dormeuse. Aus de Labordes Choix de Chansons. Paris, 1773, Band I. (501) Der Holzschnitt in Frankreich ([504]) [Abb.]: ([504]) Der Farbenkupferstich (506) [Abb.]: Jean Baptiste Le Prince. Die Reisenden. Hédou 175. I. (509) [Abb.]: (514) Der Kupferstich in Italien. ([515]) [Abb.]: Raffaello Morghen, nach Angelica Kauffmann. Bildnis der Domenica Volpato. (517) [Abb.]: Felice Polanzani. Bildnis des Camillo Tachetti. (521) [Abb.]: Giovanni Battista Tiepolo. Aus dem Scherzi di fantasia. Original 230x175 mm. ([523]) [Abb.]: Giovanni Domenico Tiepolo. Die h. Margherita de Cortona. ([525]) [Abb.]: Antonio Canale gen. Canaletto. Die Brücke mit der Osteria. Meyer 31. (527) [Abb.]: Bernardo Belotto. Das Obertor der Stadt Pirna. Meyer 24. Ausschnitt. ([530]) [Abb.]: Giovan Battista Piranesi. Der Tempel des Jupiter. Ausschnitt. ([533]) [Abb.]: Francesco Bartolozzi. Sappho und Amor. (536) Der Kupferstich in Deutschland. ([538]) [Abb.]: Daniel Chodowiecki. Das Brandenburger Tor zu Berlin. ([538]) [Abb.]: Georg Friedrich Schmidt. Bildnis König Friedrichs II. von Preußen. (541) [Abb.]: Georg Friedrich Schmidt. Bildnis seiner Gattin. Wessely 105. (543) [Abb.]: Salomon Geßner. Landschaft. Aus den Contes moraux nouvelles. 1773. (547) [Abb.]: Daniel Chodowiecki. Illustration zu Lessings Minna von Barnhelm. (551) [Abb.]: Daniel Chodowiecki. Illustration zu Lessings Minna von Barnhelm. (552) [Abb.]: Salomon Geßner. Aus den Contes moraux et noevelles idylles. 1773. (553) Der Holzschnitt in Deutschland. ([554]) [Abb.]: Johann Georg Unger, nach Meil. ([554]) Der Kupferstich in England. ([556]) [Abb.]: William Hogart. Die lachenden Zuhörer. (561) Der Holzschnitt in England. ([563]) [Abb.]: Thomas Bewick. Aus den British Birds. ([563]) [Abb.]: (566) Der Kupferstich in Spanien. ([567]) [Abb.]: Francisco Goya. "Volaverunt." Aus den Caprichos. ([569]) Verzeichnis einer Reihe der wichtigsten Schriften über den Bilddruck. ([573]) Abbildungswerke. Über die Technik des Bilddruckes. ([573]) Handbücher für Sammler. ([573]) Geschichte des Bilddruckes, allgemein u. einzelne Zweige. (574) Geschichte des Bilddruckes in einzelnen Ländern und in einzelnen Epochen. (574) Künstlerlexica und Oeuvre-Kataloge. (576) Über einzelne Künstler, größere Monographien und neuere Schriften. (576) Verzeichnis der Abbildungen. ([581]) Register. ([587]) A ([587]) B ([587]) C (589) D (590) E (591) F (591) G (592) H (592) J, K (593) L (593) M (594) N, O (596) P (596) Q (597) R (597) S (598) T, U (599) V (599) W (600) Y, Z (601) Einband ( - ) Einband ( - )

We measure a large set of observables in inclusive charged current muon neutrino scattering on argon with the MicroBooNE liquid argon time projection chamber operating at Fermilab. We evaluate three neutrino interaction models based on the widely used GENIE event generator using these observables. The measurement uses a data set consisting of neutrino interactions with a final state muon candidate fully contained within the MicroBooNE detector. These data were collected in 2016 with the Fermilab Booster Neutrino Beam, which has an average neutrino energy of MeV, using an exposure corresponding to 5.0x1019 protons-on-target. The analysis employs fully automatic event selection and charged particle track reconstruction and uses a data-driven technique to separate neutrino interactions from cosmic ray background events. We find that GENIE models consistently describe the shapes of a large number of kinematic distributions for fixed observed multiplicity. ; Public domain authored by a U.S. government employee

The MicroBooNE detector utilizes a liquid argon time projection chamber (LArTPC) with an 85 t active mass to study neutrino interactions along the Booster Neutrino Beam (BNB) at Fermilab. With a deployment location near ground level, the detector records many cosmic muon tracks in each beam-related detector trigger that can be misidentified as signals of interest. To reduce these cosmogenic backgrounds, we have designed and constructed a TPC-external Cosmic Ray Tagger (CRT). This sub-system was developed by the Laboratory for High Energy Physics (LHEP), Albert Einstein center for fundamental physics, University of Bern. The system utilizes plastic scintillation modules to provide precise time and position information for TPC-traversing particles. Successful matching of TPC tracks and CRT data will allow us to reduce cosmogenic background and better characterize the light collection system and LArTPC data using cosmic muons. In this paper we describe the design and installation of the MicroBooNE CRT system and provide an overview of a series of tests done to verify the proper operation of the system and its components during installation, commissioning, and physics data-taking. ; Public domain authored by a U.S. government employee

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Boyko, A7 Towards personalized physiotherapeutic approach, Joanna Bauer, Ewa Boerner, Halina Podbielska, A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases, Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko, A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution, Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu, A10 PPPM in cardiovascular medicine in 2015, Hans-Peter Brunner-La Rocca, A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results, Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak, A12 Ultrasound diagnosis for diabetic neuropathy - comparative study, Rostyslav V. Bubnov, Tetyana V. Ostapenko, A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results, Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak, A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer, John Paul Cauchi, A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well?, Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov, A16 Survey of questionnaires for evaluation of the quality of life in various medical fields, Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska, A17 Personalized molecular treatment for muscular dystrophies, Sebahattin Cirak, A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC, Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi, A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses, Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim, A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants, Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani, A21 Mental indicators at young people with attributes hypertension and pre-hypertension, Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova, A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies, Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva, A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors, Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova, A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon?, Shantanu Girotra, Olga Golubnitschaja, A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease, Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka, A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU, Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch, A27 Immunohistochemical assessment of APUD cells in endometriosis, Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov, A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women, Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk, A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases, Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov, A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries, Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov, A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols, Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver, A32 The correlation of dietary habits with gingival problems during menstruation, Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva, A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience, Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz, A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease, Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, A35 Metabolic hallmarks of cancer as targets for a personalized therapy, John Ionescu, A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer, Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva, A37 Challenges in diabetic macular edema, Tatjana Josifova, A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola, A39 EPMA initiative for effective organization of medical travel: European concepts and criteria, Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, A40 Design and innovation in e-textiles: implications for PPPM, Anthony Kent, Tom Fisher, Tilak Dias, A41 Biobank in Pilsen as a member of national node BBMRI_CZ, Judita Kinkorová, Ondřej Topolčan, A42 Big data in personalized medicine: hype and hope, Matthias Kohl, A43 The 3P approach as the platform of the European Dentistry Department (DPPPD), Anatoly A. Kunin, Natalia S. Moiseeva, A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention, Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan, A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction, Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov, A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care, Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka, A47 Targeting "disease signatures" towards personalized healthcare, Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini, A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis, Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska, A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials, Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin, A50 The use of LED radiation in prevention of dental diseases, Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev, A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials, Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban, A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren's syndrome: predictive and personalized treatment potentials, Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban, A53 Maximal aerobic capacity - important quality marker of health, Jaroslav Novák, Milan Štork, Václav Zeman, A54 The EMPOWER project: laboratory medicine and Horizon 2020, Wytze P. Oosterhuis, Elvar Theodorsson, A55 Personality profile manifestations in patient's attitude to oral care and adherence to doctor's prescriptions, Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda, A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine, Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta, A57 MCI or early dementia predictive speech based diagnosis techniques, Matus Pleva, Jozef Juhar, A58 Personalized speech based mobile application for eHealth, Matus Pleva, Jozef Juhar, A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients, Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka, A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen, Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan, A61 Sleep apnea and sleep fragmentation contribute to brain aging, Kneginja Richter, Lence Miloseva, Günter Niklewski, A62 Personalised approach for sleep disturbances in shift workers, Kneginja Richter, Jens Acker, Guenter Niklewski, A63 Medical travel and innovative PPPM clusters: new concept of integration, Olga Safonicheva, Vincenzo Costigliola, A64 Medical travel and women health, Olga Safonicheva, A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery, Maxim Sautin, Janna Sinelnikova, Sergey Suchkov, A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany, Songül Secer, Stephan von Bandemer, A67 Women's increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine, Niva Shapira, A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases, Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva, A69 Use of specially treated composites in dentistry to avoid violations of aesthetics, Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva, A70 National eHealth system – platform for preventive, predictive and personalized diabetes care, Ivica Smokovski, Tatjana Milenkovic, A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine, Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov, A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives, Krishna Chander Sridhar, Olga Golubnitschaja, A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures, Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov, A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM), Elvar Theodorsson, EFLM, A76 New spectroscopic techniques for point of care label free diagnostics, Syed A. M. Tofail, A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine, Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2, A78 Modern medical terminology (MMT) as a driver of the global educational reforms, Evgeniya Tretyak, Maria Studneva, Sergey Suchkov, A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants, Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato, A80 Proteomarkers Biotech, George Th. Tsangaris, Athanasios K. Anagnostopoulos, A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications, George Th. Tsangaris, Athanasios K. Anagnostopoulos, A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH), José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium, A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project), José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium, A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents, Igor Volchek, Nina Pototskaya, Andrey Petrov, A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening, Igor Volchek, Nadezhda Pototskaya, Andrey Petrov, A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life, Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag, A87 Sub-optimal health management – global vision for concepts in medical travel, Wei Wang, A88 Sub-optimal health management: synergic PPPM-TCAM approach, Wei Wang, A89 Innovative technologies for minimal invasive diagnostics, Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger, A90 Rare disease diobanks for personalized medicine, Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Diseases