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This paper presents a remote testbed for metallic fuel fabrication using surrogates or depleted uranium. The testbed named "remote fuel fabrication mock-up (RFFM)" was created at the Korea Atomic Energy Research Institute and specifically designed to incorporate remote operation and maintenance. The subsystems of the RFFM are described, and test results regarding remotely conducted metallic fuel slug fabrication at the RFFM are also presented. After fabricating fuel slugs using copper ingots, their specifications and properties were analyzed and evaluated using chemical analysis, radiographic tests, and diameter and weight measurements. Analysis results showed that the fabricated metallic fuel slugs have an acceptance rate of more than 90% and a casting ratio (ratio of weight of injected metal to charged metal) of more than 0.7. Moreover, operations involving remote handling of in-cell equipment were also satisfactory.

AbstractFeminism, the empowerment of women, and gender equality are frequently discussed concepts in contemporary India. The film industry, among other stakeholders, is taking steps to contribute to women's empowerment. In India, the film industry is seeking to change society by touching on topics that are rarely discussed in public. Contemporary directors have begun to give greater visibility to the problems women face. There is a new wave of women‐centric movies that is bringing about a quiet rebellion in India. This article reveals how women's values are portrayed in select Indian movies.

In Korea, R&D on a sodium-cooled fast reactor (SFR) was begun in 1997, as one of the national long-term nuclear R&D programs. As one fuel option for a prototype SFR, a metallic fuel, U-Zr alloy fuel, was selected and is currently being developed. For the fabrication of SFR metallic fuel rods, the end plug welding is a crucial process. The sealing of the end plug to the cladding tube should be hermetically perfect to prevent a leakage of fission gases and to maintain a good reactor performance. In this study, the welding technique, welding equipment, welding conditions, and parameters were developed for the end plug welding of SFR metallic fuel rods. A gas tungsten arc welding (GTAW) technique was adopted and the welding joint design was developed. In addition, the optimal welding conditions and parameters were established. Based on the establishment of the welding conditions, the GTAW technique was qualified for the end plug welding of SFR metallic fuel rods.

Background A. oxyphylla extract is known to possess a wide range of pharmacological activites. However, the molecular mechanism of A. oxyphylla and its bioactive compound nootkatone in colorectal cancer is unknown. Methods Our study aims to examine the role of A. oxyphylla and its bioactive compound nootkatone, in tumor suppression using several in vitro assays. Results Both A. oxyphylla extract and nootkatone exhibited antiproliferative activity in colorectal cancer cells. A. oxyphylla displayed antioxidant activity in colorectal cancer cells, likely mediated via induction of HO-1. Furthermore, expression of pro-apoptotic protein NAG-1 and cell proliferative protein cyclin D1 were increased and decreased respectively in the presence of A. oxyphylla. When examined for anticancer activity, nootkatone treatment resulted in the reduction of colony and spheroid formation. Correspondingly, nootkatone also led to increased NAG-1 expression and decreased cyclin D1 expression. The mechanism by which nootkatone suppresses cyclin D1 involves protein level regulation, whereas nootkatone increases NAG-1 expression at the transcriptional level. In addition to having PPARγ binding activity, nootkatone also increases EGR-1 expression which ultimately results in enhanced NAG-1 promoter activity. Conclusion In summary, our findings suggest that nootkatone is an anti-tumorigenic compound harboring antiproliferative and pro-apoptotic activity. ; This work was supported by the Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research Center, Seoul National University, and by a National Research Foundation of Korea (NRF) grant funded by the Korean government (2018R1A2B2002923) to S.J.B. This work was also partially supported by a clinical research grant (NCC1810150) provided by the National Cancer Center to J.R. and S.J.B. The Fig. 7 Nootkatone controls the NAG-1 expression at the transcriptional level. a Nootkatone increases NAG-1 promoter activity. HCT-116 cells were transfected with pNAG-1 − 1086/+ 41 luciferase and pRL-null plasmid. The cells were treated with EtOH or various concentrations of nootkatone for 24 h, and luciferase activity was measured. The y-axis refers to the ratio of firefly luciferase over renillar luciferase activity. The EtOH-treated cells were set as 1.0. Statistical significance was displayed as *p < 0.05, ***p < 0.001 versus EtOH-treated cells. The data represent mean ± SD from three independent experiments. b Three deletion NAG-1 promoter constructs were co-transfected with pRL-null vector into HCT-116 cells. The cells were treated with EtOH or 100 μM of nootkatone for 24 h, and luciferase activity was measured. Fold induction refers to the ratio of luciferase activity in nootkatone-treated cells versus EtOH-treated cells. Statistical significance was displayed as **p < 0.01 and ***p < 0.001 versus EtOH-treated cells. The data represent mean ± SD from three independent experiments. c HCT-116 cells were co-transfected with wild type pNAG-1 − 133/+ 41 in the presence of empty or EGR-1 expression vector. Cells were subsequently treated with 100 μM nootkatone for 24 h. The results are presented as means ± S.D. of three independent transfections. d Western blot of EGR-1 protein in the presence of nootkatone. β-actin was used as loading control. e Luciferase activity of EGR-1 promoter-luciferase construct (pEGR-1260-LUC). The cells were treated with EtOH or nootkatone for 24 h prior to measurement of luciferase activity. Fold induction refers to the ratio of luciferase activity in nootkatone-treated cells compared to EtOH-treated cells. Statistical significance represented as *p < 0.05, ***p < 0.001 versus EtOH-treated cells. n.s. represents not significant. The data represent mean ± SD from four independent experiments Yoo et al. BMC Cancer (2020) 20:881 Page 10 of 12 funding agency did not have any influence in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

AbstractHow can business respond to the challenge that Greta Thunberg has presented to world leaders? Sustainable marketing, as part of a larger strategy of meeting sustainable goals, is one way. It has become an important practice in the 21st‐century business world. Without a healthy society and environment, economies will fail, and businesses will die with them. Thus, companies increasingly realize that investing in social and environmental improvements not only adds to their credibility; it also increases their long‐term profitability. Consumers expect companies to develop sustainable marketing strategies. But it is difficult for companies to keep up with these rising expectations. As a result, there is often a gap between sustainable marketing efforts and consumer demands. Those demands can be unrealistic in terms of the cost of compliance and the time required to alter production processes. Sustainable marketing makes sense only as part of a strategy that will guide all of the actions of a business, not just product development, sales, and marketing. Since governments are slow to take up the challenge offered by Greta Thunberg, the future of the planet depends on the actions taken by companies to protect the environment and create a better society.