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Abstract
The extrastriate body area (EBA) is a region in the lateral occipito-temporal cortex (LOTC), which is sensitive to perceived body parts. Neuroimaging studies suggested that EBA is related to body and tool processing, regardless of the sensory modalities. However, how essential this region is for visual tool processing and nonvisual object processing remains a matter of controversy. In this preregistered fMRI-guided repetitive transcranial magnetic stimulation (rTMS) study, we examined the causal involvement of EBA in multisensory body and tool recognition. Participants used either vision or haptics to identify 3 object categories: hands, teapots (tools), and cars (control objects). Continuous theta-burst stimulation (cTBS) was applied over left EBA, right EBA, or vertex (control site). Performance for visually perceived hands and teapots (relative to cars) was more strongly disrupted by cTBS over left EBA than over the vertex, whereas no such object-specific effect was observed in haptics. The simulation of the induced electric fields confirmed that the cTBS affected regions including EBA. These results indicate that the LOTC is functionally relevant for visual hand and tool processing, whereas the rTMS over EBA may differently affect object recognition between the 2 sensory modalities.

Prof. Edward (Ed) Diener (1946-2021), a pioneer in positive psychology, passed away on the 27th of April 2021 at his home in Salt Lake City, Utah (Salt Lake City Tribune, 2021). As one of the most influential psychologists of the discipline, Ed Diener pushed the boundaries of our understanding of positive psychological functioning, subjective well-being, and happiness (Layous, 2020). As one of the Top 200 most cited researchers across all disciplines and fields, he will be most remembered for founding the scientific study of subjective well-being (SWB) and happiness (Bakshi, 2019). Diener developed the concept of subjective well-being by exploring the factors that influence people's life satisfaction (Diener et al., 2017a). He studied the individual causes of subjective well-being, such as close social relationships, income, meaning and purpose, personality, and societal causes, such as economic development, low corruption and crime, and a healthy environment (Diener et al., 2018). His research has discovered both universal and culture-specific causes and consequences of SWB and influenced governmental policy (Oishi et al., 1999). In respect of his memory, the purpose of this paper is threefold: (a) to reflect upon his career journey, (b) to celebrate his significant contributions to the discipline, and (c) to provide personal reflections of those who worked closely with him over the past 50 years.

Prof. Edward (Ed) Diener (1946-2021), a pioneer in positive psychology, passed away on the 27thof April 2021 at his home in Salt Lake City, Utah (Salt Lake City Tribune, 2021). As one of the most influential psychologists of the discipline, Ed Diener pushed the boundaries of our understanding of positive psychological functioning, subjective well-being, and happiness (Layous, 2020). As one of the Top 200 most cited researchers across all disciplines and fields, he will be most remembered forfounding the scientific study of subjective well-being (SWB) and happiness (Bakshi, 2019). Diener developed the concept of subjective well-being by exploring the factors that influence people's life satisfaction (Diener et al., 2017a). He studied the individual causes of subjective well-being, such as close social relationships, income, meaning and purpose, personality, and societal causes, such as economic development, low corruption and crime, and a healthy environment (Diener et al., 2018).His research has discovered both universal and culture-specific causes and consequences of SWB and influenced governmental policy (Oishi et al., 1999). In respect of his memory, the purpose of this paper is threefold: (a)to reflect upon his career journey, (b) to celebrate his significant contributions to the discipline, and (c) to provide personal reflections of those who worked closely with him over the past 50 years.

Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast percentage of cancer patient mortality. While advances in this area have been made, the process of cancer metastasis and the factors governing cancer spread and establishment at secondary locations is still poorly understood. The current article summarizes recent progress in this area of research, both in the understanding of the underlying biological processes and in the therapeutic strategies for the management of metastasis. This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB-1) and transforming growth factor beta (TGF-β), together with inactivation of activator protein-1 (AP-1) and suppression of matrix metalloproteinase-9 (MMP-9) activity as key targets and the use of phytochemicals, or natural products, such as those from Agaricus blazei, Albatrellus confluens, Cordyceps militaris, Ganoderma lucidum, Poria cocos and Silybum marianum, together with diet derived fatty acids gamma linolenic acid (GLA) and eicosapentanoic acid (EPA) and inhibitory compounds as useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer. Together, these strategies could represent new, inexpensive, low toxicity strategies to aid in the management of cancer metastasis as well as having holistic effects against other cancer hallmarks.

16 pags., 9 figs., 5 tabs. ; A first -ray study of spectroscopy was performed at the Radioactive Isotope Beam Factory with projectiles at 217 MeV/nucleon, impinging on the liquid hydrogen target of the MINOS device. Prompt deexcitation rays were measured with the NaI(Tl) array DALI2. Through the one-proton knockout reaction , a spin assignment could be determined for the low-lying states of from the momentum distribution obtained with the SAMURAI spectrometer. A spin-parity is deduced for the ground state of , similar to the recently studied isotope . The evolution of the energy difference is compared to state-of-the-art theoretical predictions. ; We thank the RIKEN Nishina Center accelerator staff for their work in the primary beam delivery and the BigRIPS team for preparing the secondary beams. The development of MINOS has been supported by the European Research Council through the ERC Grant No. MINOS258567. B.D.L., L.X.C., and N.D.T. acknowledge support from the Vietnam Ministry of Science and Technology under Grant No. ĐTCB.01/21/VKHKTHN. M.G.R. and A.M.M. are supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (including FEDER funds) under project FIS2017-88410-P. F.B. was supported by the RIKEN Special Postdoctoral Researcher Program. Y.L.S. acknowledges the support of Marie Skłodowska-Curie Individual Fellowship (H2020-MSCAIF-2015-705023) from the European Union. I.G. has been supported by HIC for FAIR and Croatian Science Foundation. R.-B.G. is supported by the Deutsche Forschungsgemeinschaft (DFG) under Grant No. BL 1513/1-1. K.I.H., D.K., and S.Y.P. acknowledge the support from the IBS grant funded by the Korea government (No. IBS-R031-D1). P.K. was supported in part by the BMBF Grant No. 05P19RDFN1 and HGS-HIRe. D.So. has been supported by the European Regional Development Fund Contract No. GINOP-2.3.3-15-2016-00034 and the National Research, Development and Innovation Fund of Hungary via Project No. K128947. This work was supported in part by JSPS KAKENHI Grants No. JP16H02179, No. JP18H05404, and No. JP20K03981. J.D.H. and R.S. acknowledge the support from NSERC and the National Research Council Canada. This work was supported by the Office of Nuclear Physics, U.S. Department of Energy, under Grants No. de-sc0018223 (NUCLEI SciDAC-4 collaboration) and the FieldWork Proposal ERKBP72 at Oak Ridge National Laboratory (ORNL). Computer time was provided by the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program. This research used resources of the Oak Ridge Leadership Computing Facility located at ORNL, which is supported by the Office of Science of the Department of Energy under Contract No. DE-AC05-00OR22725. GGF calculations were performed by using HPC resources from GENCI-TGCC (Contracts No. A007057392 and No. A009057392) and at the DiRAC Complexity system at the University of Leicester (BIS National E-infrastructure capital Grant No. ST/K000373/1 and STFC Grant No. ST/K0003259/1). This work was supported by the United Kingdom Science and Technology Facilities Council (STFC) under Grant No. ST/L005816/1 and in part by the NSERC Grants No. SAPIN-2016-00033, No. SAPIN-2018-00027, and No. RGPAS-2018-522453. TRIUMF receives federal funding via a contribution agreement with the National Research Council of Canada. J.D.H. thanks S. R. Stroberg for the IMSRG++ code used to perform the VSIMSRG calculations [86]. N.T.T.P. was funded by Vingroup Joint Stock Company and supported by the Domestic Ph.D. Scholarship Programme of Vingroup Innovation Foundation (VINIF), Vingroup Big Data Institute (VINBIGDATA), code VINIF.2020.TS.52.

7 pags., 3 figs., 1 tab. ; We report on the first γ-ray spectroscopy of K produced via the Ca(p,2p) reactions at ∼250 MeV/nucleon. Unambiguous final-state angular-momentum assignments were achieved for beam intensities down to few particles per second by using a new technique based on reaction vertex tracking combined with a thick liquid-hydrogen target. Through γ-ray spectroscopy and exclusive parallel momentum distribution analysis, 3/2 ground states and 1/2 first excited states in K were established quantifying the natural ordering of the 1d and 2s proton-hole states that are restored at N = 32 and 34. State-of-the-art ab initio calculations and shell-model calculations with improved phenomenological effective interactions reproduce the present data and predict consistently the increase of the E(1/2 ) - E(3/2 ) energy differences towards N = 40. ; We are very grateful to the RIKEN Nishina Center accelerator staff for providing the stable and high-intensity zinc beam and to the BigRIPS team for the smooth operation of the secondary beams. The development of MINOS has been supported by the European Research Council through the ERC Grant No. MINOS-258567. Green's function calculations were performed using HPC resources from GENCI-TGCC, France (Projects A0030507392 and A0050507392) and from the DiRAC Data Intensive service at Leicester, UK (funded by the UK BEIS via STFC capital grants ST/K000373/1 and ST/R002363/1 and STFC DiRAC Operations grant ST/R001014/1). This work (C. B.) was also supported by the United Kingdom Science and Technology Facilities Council (STFC) under Grants No. ST/P005314/1 and No. ST/L005816/1. K. O. acknowledges the support by Grant-in-Aid for Scientific Research JP16K05352. Y. L. S. acknowledges the support of Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2015-705023) from the European Union and the support from the Helmholtz International Center for FAIR. The valuable discussions with C. Qi are gratefully acknowledged. H. N. L. acknowledges the support from the Enhanced Eurotalents program (PCOFUND-GA-2013-600382) co-funded by CEA and the European Union. H. N. L. and A. O. acknowledge the support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Project No. 279384907-SFB 1245. Y. L. S. and A. O. acknowledge the support from the Alexander von Humboldt Foundation. L. X. C. and B. D. L would like to thank MOST for its support through the Physics Development Program Grant No. ĐTĐLCN.25/18. I.G. has been supported by HIC for FAIR and HRZZ under project No. 1257 and 7194. K. I. H., D. K. and S. Y. P. acknowledge the support from the NRF grant funded by the Korea government (No. 2017R1A2B2012382 and 2019M7A1A1033186). F. B. acknowledge the support from the RIKEN Special Postdoctoral Researcher Program. D.S. was supported by projects No. GINOP-2.3.3-15-2016-00034 and No. K128947. V. V. acknowledges support from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2017-84756-C4-2-P. V. W. acknowledges support from BMBF grants 05P15RDFN1, 05P19RDFN1 and DFG grant SFB 1245. P. K. acknowledges support from HGS-HIRe and BMBF grant 05P19RDFN1. This work was also supported by NKFIH (128072).

9 pags., 6 figs., 4 tabs. ; Low-lying excited states in the N=32 isotope Ar50 were investigated by in-beam γ-ray spectroscopy following proton- and neutron-knockout, multinucleon removal, and proton inelastic scattering at the RIKEN Radioactive Isotope Beam Factory. The energies of the two previously reported transitions have been confirmed, and five additional states are presented for the first time, including a candidate for a 3- state. The level scheme built using γγ coincidences was compared to shell-model calculations in the sd-pf model space and to ab initio predictions based on chiral two- and three-nucleon interactions. Theoretical proton- and neutron-knockout cross sections suggest that two of the new transitions correspond to 2+ states, while the previously proposed 41+ state could also correspond to a 2+ state. ; We thank the RIKEN Nishina Center accelerator staff and the BigRIPS team for the stable operation of the high-intensity Zn beam and for the preparation of the secondary beam setting. This work has been supported by the JSPS Grant-in-Aid for Scientific Research JP16K05352, JP18K03639, JP16H02179, and JP18H05404, the RIKEN Special Postdoctoral Researcher Program, Colciencias–Convocatoria 617 Becas Doctorados Nacionales, the Ministry of Science and Technology of Vietnam through the Physics Development Program Grant No. ĐTĐLCN.25/18, HIC for FAIR, the Croatian Science Foundation under Projects No. 1257 and No. 7194, the European Regional Development Fund GINOP-2.3.3-15- 2016-00034 and the National Research, Development and Innovation Fund K128947 projects, the NKFIH (128072), the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2017-84756-C4-2-P, the NRF Grants No. 2018R1A5A1025563 and No. 2019M7A1A1033186 funded by the Korean government, the MEXT as "Priority issue on post-K computer" (Elucidation of the fundamental laws and evolution of the universe), the Joint Institute for Computational Fundamental Science (JICFuS), the Ramón y Cajal program RYC-2017-22781 of the Spanish Ministry of Science, Innovation and Universities, the Natural Sciences and Engineering Research Council (NSERC) of Canada, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Project-ID 279384907–SFB 1245 and Grant No. BL 1513/1-1, the PRISMA Cluster of Excellence, and the BMBF under Contracts No. 05P15RDFN1, No. 05P18RDFN1, and No. 05P19RDFN1. TRIUMF receives funding via a contribution through the National Research Council Canada. Computations were performed with an allocation of computing resources on Cedar at WestGrid and Compute Canada, and on the Oak Cluster at TRIUMF managed by the University of British Columbia, Department of Advanced Research Computing (ARC). The development of MINOS was supported by the European Research Council (ERC) through Grant No. MINOS-258567.

7 pags., 4 figs., 1 tab. ; Exclusive cross sections and momentum distributions have been measured for quasifree one-neutron knockout reactions from a Ca54 beam striking on a liquid hydrogen target at ∼200 MeV/u. A significantly larger cross section to the p3/2 state compared to the f5/2 state observed in the excitation of Ca53 provides direct evidence for the nature of the N=34 shell closure. This finding corroborates the arising of a new shell closure in neutron-rich calcium isotopes. The distorted-wave impulse approximation reaction formalism with shell model calculations using the effective GXPF1Bs interaction and ab initio calculations concur our experimental findings. Obtained transverse and parallel momentum distributions demonstrate the sensitivity of quasifree one-neutron knockout in inverse kinematics on a thick liquid hydrogen target with the reaction vertex reconstructed to final state spin-parity assignments. ; We would like to express our gratitude to the RIKEN Nishina Center accelerator staff for providing the stable and high-intensity beam andtotheBigRIPSteam for operatingthe secondary beams. S. C. acknowledges the support of the IPA program at RIKEN Nishina Center. J. L. acknowledges the support from Research Grants Council (RGC) of Hong Kong with grant of Early Career Scheme (ECS-27303915). K. O., K. Y., and Y. C. acknowledge the support from Grants-in-Aid of the Japan Society for the Promotion of Science under Grants No. JP16K05352. Y. L. S. acknowledges the support of the Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2015-705023). V. V. acknowledges support from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2017- 84756-C4-2-P. L. X. C. and B. D. L. would like to thank MOST for its support through the Physics Development Program Grant No. ĐTĐLCN.25/18. D. R. and V. W. acknowledge the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Grant No. SFB1245. V. W. and P. K. acknowledge the German BMBF Grant No. 05P19RDFN1. P. K. was also supported by HGSHIRe. D. S. was supported by Projects No. GINOP-2.3.3- 15-2016-00034 and No. NKFIH-NN114454. I. G. has been supported by HIC for FAIR and Croatian Science Foundation under Projects No. 1257 and No. 7194. K. I. H., D. K., and S. Y. P. acknowledge the support from the NRF grant funded bythe Korea government (No. 2016K1A3A7A09005580 and No. 2018R1A5A1025563). This work was also supported by the United Kingdom Science and Technology Facilities Council (STFC) under Grants No. ST/P005314/1 and No. ST/L005816/1, and by NKFIH (128072), and by JSPS KAKENHI Grant No. 16H02179, and by MEXT KAKENHI Grant No. 18H05404. The development of MINOS were supported by the European Research Council through the ERC Grant No. MINOS-258567. Green's function calculations were performed using HPC resources from the DiRAC Data Intensive service at Leicester, UK (funded by the UK BEIS via STFC capital Grants No. ST/K000373/1 and No. ST/R002363/1 and STFC DiRAC Operations Grant No. ST/R001014/1) and from GENCI-TGCC, France (Project No. A0050507392).

7 pags., 3 figs., 1 tab. -- Open Access funded by Creative Commons Atribution Licence 4.0 ; The first γ-ray spectroscopy of Ar52, with the neutron number N=34, was measured using the K53(p,2p) one-proton removal reaction at ∼210 MeV/u at the RIBF facility. The 21+ excitation energy is found at 1656(18) keV, the highest among the Ar isotopes with N>20. This result is the first experimental signature of the persistence of the N=34 subshell closure beyond Ca54, i.e., below the magic proton number Z=20. Shell-model calculations with phenomenological and chiral-effective-field-theory interactions both reproduce the measured 21+ systematics of neutron-rich Ar isotopes, and support a N=34 subshell closure in Ar52. ; We thank the RIKEN Nishina Center accelerator staff for their work in the primary beam delivery and the Big RIP Steam for preparing the secondary beams. The development of MINOS has been supported by the European Research Council through the ERC Grant No. MINOS 258567. Acknowledges the support from the Enhanced Eurotalents program (PCOFUND-GA-2013-600382) co-funded by CEA and the European Union. H.N.L., A.O. and A.S. acknowledge the support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Project No. 279384907- SFB 1245. C.A.B. acknowledges support from the U.S. NSF Grant No. 1415656 and the U.S. DOE Grant No.DE-FG02-08ER41533.J.D.H.and R.S.acknowledge the support from NSERC and the National Research Council Canada. Y.L.S. acknowledges the support of Marie Skłodowska-Curie Individual Fellowship (H2020-MSCAIF-2015-705023) from the European Union. I.G. has been supported by HIC for FAIR andCroatianScienceFoundation. L.X.C. and B.D.L. have been supported by the Vietnam MOST through the Physics Development Program Grant No. ĐTĐLCN.25/18. K.I.H., D.K. and S.Y.P. have been supported by the NRF grant funded by the Korea government (No. 2017R1A2B2012382 and 2018R1A5A1025563). This work was supported in part by JSPS KAKENHI Grant No. 16H02179, MEXT KAKENHI Grants No. 24105005 and No. 18H05404. This work was also supported by the Office of Nuclear Physics,U.S.Department of Energy,under Grants No.de-sc 0018223 (NUCLEISciDAC-4collaboration) and the Field Work Proposal ERKBP72 at Oak Ridge National Laboratory (ORNL). Computer time was provided by the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program. Thisresearch used resources of the Oak Ridge Leadership Computing Facility located at ORNL, which is supported by the Office of Science of the Department of Energy under Contract No. DE-AC0500OR22725.

7 pags. 4 figs. ; Fifty-five inclusive single nucleon-removal cross sections from medium mass neutron-rich nuclei impinging on a hydrogen target at ∼250 MeV/nucleon are measured at the RIKEN Radioactive Isotope Beam Factory. Systematically higher cross sections are found for proton removal from nuclei with an even number of protons as compared to odd-proton number projectiles for a given neutron separation energy. Neutron removal cross sections display no even-odd splitting, contrary to nuclear cascade model predictions. Both effects are understood through simple considerations of neutron separation energies and bound state level densities originating in pairing correlations in the daughter nuclei. These conclusions are supported by comparison with semimicroscopic model predictions, highlighting the enhanced role of low-lying level densities in nucleon-removal cross sections from loosely bound nuclei. ; We express our gratitude to the RIKEN Nishina Center accelerator staff for providing the stable and high-intensity uranium beam . A. O. thanks the European Research Council for its support through ERC Grant No. MINOS-258567, the Japanese Society for the Promotion of Science for the long-term fellowship L-13520, the German DFG SFB Grant No. 1245, and the Alexander von Humboldt Foundation. C. S. acknowledges support by the IPA program at the RIKEN Nishina Center. C. A. B. acknowledges support by U.S. Department of Energy Grant No. DE-FG02- 08ER41533 and U.S. National Science Foundation Grant No. 1415656. J. L. R.-S. acknowledges support by the Regional Government of Galicia under the program of postdoctoral fellowships. K. M. acknowledges support from German BMBF Grant No. 05P15PKFNA. M. L. C., M. L., and V. W. acknowledge support from German BMBF Grants No. 05P12RDFN8, No. 05P15RDFN1, and No. 05P12RDFN8, as well as DFG Grant No. SFB 1245. L. X. C. and B. D. L. are supported by the Vietnam MOST through Physics Development Program Grant No. ĐTĐLCN.25/18 and acknowledge the Radioactive Isotope Physics Laboratory of the RIKEN Nishina Center for supporting their stay during the experiment. A. J. and V. V. acknowledge support from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2014-57196-C5-4-P. U.K. participants acknowledge support from the Science and Technology Facilities Council (STFC). Collaborators from I. M. P. were supported by the National Natural Science Foundation of China and the Chinese Academy of Sciences.

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Participants were 30,785 dementia-free individuals aged 55–103 years, from 18 longitudinal cohort studies, with an average follow-up ranging between 2 and 10 years. Pooled hazard ratios were obtained from multilevel parametric survival analyses predicting cognitive impairment (CI) from education and its interactions with baseline age, sex, APOE*4 and ethnicity. In separate models, education was treated as continuous (years) and categorical, with participants assigned to one of four education completion levels: Incomplete Elementary; Elementary; Middle; and High School. Results: Compared to Elementary, Middle (HR = 0.645, P = 0.004) and High School (HR = 0.472, P < 0.001) education were related to reduced CI risk. The decreased risk of CI associated with Middle education weakened with older baseline age (HR = 1.029, P = 0.056) and was stronger in women than men (HR = 1.309, P = 0.001). The association between High School and lowered CI risk, however, was not moderated by sex or baseline age, but was stronger in Asians than Whites (HR = 1.047, P = 0.044), and significant among Asian (HR = 0.34, P < 0.001) and Black (HR = 0.382, P = 0.016), but not White, APOE*4 carriers. Conclusion: High School completion may reduce risk of CI associated with advancing age and APOE*4. The observed ethnoregional differences in this effect are potentially due to variations in social, economic, and political outcomes associated with educational attainment, in combination with neurobiological and genetic differences, and warrant further study.