Suchergebnisse

Jian Huang,1,* Yun Yang,1,* Yong Xia,2,* Fu-Chen Liu,1,* Lei Liu,1 Peng Zhu,1 Sheng-Xian Yuan,1 Fang-Ming Gu,1 Si-Yuan Fu,1 Wei-Ping Zhou,1 Hui Liu,1 Bei-Ge Jiang,1 Ze-Ya Pan1 1The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University (Second Military Medical University), Shanghai, 201805, People's Republic of China; 2Department of Medical Oncology, Shanghai Mengchao Cancer Hospital, Shanghai, 201805, People's Republic of China*These authors contributed equally to this workCorrespondence: Ze-Ya Pan; Bei-Ge Jiang No. 700, MoYu North Road, Jiading, Shanghai, People's Republic of ChinaTel +86-13391236437; +86-13764561303Email hjluffy@126.com; jiang_beige@aliyun.comPurpose: To predict patient survival in early-stage hepatocellular carcinoma (HCC) following hepatic resection. We evaluated the prognostic potential of the aspartate aminotransferase to platelet ratio index (APRI) in order to use it to model a nomogram.Patients and Methods: We randomized 901 early-stage HCC patients treated with hepatic resection at our center into training and validation cohorts that were followed from January 2009 to December 2012. X-tile software was used to establish the APRI cut-off threshold in the training cohort. The validation cohort was subsequently assessed to determine threshold value accuracy. Data generated from the multivariate analysis in the training cohort were used to design a prognostic nomogram. Decision curve analyses (DCA), concordance index values (C-index) and calibration curves were used to determine the performance of the nomogram.Results: X-tile software revealed that the optimal APRI cut-off threshold in the training cohort that distinguished between patients with different prognoses was 0.9. We, therefore, validated its prognostic value. Multivariate analyses showed that poor overall survival was associated with APRI above 0.9, blood loss of more than 400 mL, liver cirrhosis, multiple tumors, tumor size greater than 5 cm, microvascular invasion and satellite lesions. When the independent risk factors were integrated into the prognostic nomogram, it performed well with accurate predictions. Indeed, the performance was better than comparative prognosticators (P< 0.05 for all) with 0.752 as the C-index (95% CI: 0.706– 0.798). These results were verified by the validation cohort.Conclusion: APRI was a noninvasive and accurate predictive indicator for patients with early-stage HCC. Following hepatic resection to treat early-stage HCC, individualized patient survival predictions can be aided by the nomogram based on APRI.Keywords: hepatocellular carcinoma, hepatic resection, survival, nomogram, aspartate aminotransferase to platelet ratio index, APRI

Metasurfaces, the ultrathin, 2D version of metamaterials, have recently attracted a surge of attention for their capability to manipulate electromagnetic waves. Recent advances in reconfigurable and programmable metasurfaces have greatly extended their scope and reach into practical applications. Such functional sheet materials can have enormous impact on imaging, communication, and sensing applications, serving as artificial skins that shape electromagnetic fields. Motivated by these opportunities, this progress report provides a review of the recent advances in tunable and reconfigurable metasurfaces, highlighting the current challenges and outlining directions for future research. To better trace the historical evolution of tunable metasurfaces, a classification into globally and locally tunable metasurfaces is first provided along with the different physical addressing mechanisms utilized. Subsequently, coding metasurfaces, a particular class of locally tunable metasurfaces in which each unit cell can acquire discrete response states, is surveyed, since it is naturally suited to programmatic control. Finally, a new research direction of software-defined metasurfaces is described, which attempts to push metasurfaces toward unprecedented levels of functionality by harnessing the opportunities offered by their software interface as well as their inter- and intranetwork connectivity and establish them in real-world applications. ; This work was supported by the European Union's Horizon 2020 research and innovation programme-Future Emerging Topics (FETOPEN) under grant agreement No 736876 (VISORSURF). Financial support by the National Priorities Research Program grant No. NPRP9-383-1-083 from the Qatar National Research Fund is also acknowledged. O.T. acknowledges the financial support of the Stavros Niarchos Foundation within the framework of the project ARCHERS ("Advancing Young Researchers' Human Capital in Cutting Edge Technologies in the Preservation of Cultural Heritage and the Tackling of Societal Challenges"). ; Peer Reviewed ; Postprint (published version)