Suchergebnisse

Intro -- Contents -- Preface -- Chapter 1 -- Soybean in India: At a Glance -- Abstract -- Abbreviations -- 1. Introduction -- 2. Methodology for Selecting Model through Arima -- 2.1. ARIMA Model -- 2.2. The Box-Jenkins Modeling Procedure -- 3. Resullts and Discussion -- 4. History of Development for Soybean Industry -- 5. Reason for Low Productivity -- Conclusion -- Recommendations -- References -- Chapter 2 -- Value Addition in Soya Bean: Production of Soya Sauce -- Abstract -- 1. Introduction -- 2. Soy Sowing and Harvesting of Soybeans -- 3. Important Varieties of Soybeans -- 3.1. Quality Characteristics of Soybeans -- 4. Production of Soy Sauce -- 4.1. Raw Materials -- 4.2. Types of Microorganisms and Fermentation Stages of Soy Sauce -- 4.3. Composition of Fermentation Media for Production of Soy Sauce -- 4.3.1. Growth Media for A. oryzae -- 4.3.2. Growth Media for Lactobacillus Delbrueckii -- 4.3.3. Growth Media for S. rouxii (salt tolerant yeast) -- 4.4. Fermentation and Application of Soy Sauce -- 5. Value Addition in Soy Proteins -- 5.1. Nutritional Compositions of Soy Sauces -- 5.2. Benefits of Soy Sauce Consumption -- Conclusion and Future Work -- References -- Chapter 3 -- Biological Effects of Soy Protein and Isoflavones: A Review -- Abstract -- 1. Introduction -- 1.1. Soy Intake across Different Countries -- 1.2. Nutritional Value of Soybeans -- 1.3. Absorption of Soy Protein -- 1.4. Metabolism of Soy Protein -- 2. Effects of Soy Protein on Some Health Parameters -- 2.1. Effect of Soy Protein and Isoflavones on Lipids -- 2.2. Effect of Soy Food on Breast and Prostate Cancer -- 2.3. Effect of Soy Food on Bones and Menopausal Symptoms -- Conclusion and Current Status -- References -- Chapter 4 -- Modified and Unmodified Soy Protein: A Versatile Protein Supplement -- Abstract -- 1. Introduction -- 2. Habitat and History

Human DNA helicase B (HELB) is a poorly characterized helicase suggested to play both positive and negative regulatory roles in DNA replication and recombination. In this work, we used bulk and single-molecule approaches to characterize the biochemical activities of HELB protein with a particular focus on its interactions with Replication Protein A (RPA) and RPA–single-stranded DNA (ssDNA) filaments. HELB is a monomeric protein that binds tightly to ssDNA with a site size of ∼20 nucleotides. It couples ATP hydrolysis to translocation along ssDNA in the 5′ to 3′ direction accompanied by the formation of DNA loops. HELB also displays classical helicase activity, but this is very weak in the absence of an assisting force. HELB binds specifically to human RPA, which enhances its ATPase and ssDNA translocase activities but inhibits DNA unwinding. Direct observation of HELB on RPA nucleoprotein filaments shows that translocating HELB concomitantly clears RPA from ssDNA. This activity, which can allow other proteins access to ssDNA intermediates despite their shielding by RPA, may underpin the diverse roles of HELB in cellular DNA transactions. ; [Significance] Single-stranded DNA (ssDNA) is a key intermediate in many cellular DNA transactions, including DNA replication, repair, and recombination. Nascent ssDNA is rapidly bound by the Replication Protein A (RPA) complex, forming a nucleoprotein filament that both stabilizes ssDNA and mediates downstream processing events. Paradoxically, however, the very high affinity of RPA for ssDNA may block the recruitment of further factors. In this work, we show that RPA–ssDNA nucleoprotein filaments are specifically targeted by the human HELB helicase. Recruitment of HELB by RPA–ssDNA activates HELB translocation activity, leading to processive removal of upstream RPA complexes. This RPA clearance activity may underpin the diverse roles of HELB in replication and recombination. ; Work in the laboratory of M.S.D. was supported by an Elizabeth Blackwell Early Career Fellowship from the University of Bristol (to O.J.W.) and Wellcome Trust Investigator Grant 100401/Z/12/Z (to M.S.D.). Work in the laboratory of E.A. was supported by NIH Grants GM130746 (to E.A.) and GM133967 (to E.A.). F.M.-H. acknowledges support from the European Research Council under European Union Horizon 2020 Research and Innovation Program Grant Agreement 681299. Work in the laboratory of F.M.-H. was also supported by Spanish Ministry of Science and Innovation Grants BFU2017-83794-P (AEI/FEDER, UE; to F.M.-H.) and PID2020-112998GB-100 (AEI/10.13039/501100011033; to F.M.-H.) and Comunidad de Madrid Grants Tec4-Bio–S2018/NMT-4443 (to F.M.-H.) and NanoBioCancer–Y2018/BIO-4747 (to F.M.-H.).

"Amendments to IFRS No. 9 with respect to classification, measurement and impairment of financial instruments. In addition, current events have focused public attention on the key role of accounting in providing information useful to decision makers. The CPA exam, too, is redirecting its focus to emphasize the professional skills needed to critically evaluate accounting method alternatives. Intermediate Accounting provides a decision maker's perspective to emphasize the professional judgment and critical thinking skills required of accountants in today's business environment"--