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A marked reduction in fertility and an increase in adverse reproductive outcomes during the last few decades have been associated with occupational and environmental chemical exposures. Exposure to different types of pesticides may increase the risks of chronic diseases, such as diabetes, cancer, and neurodegenerative disease, but also of reduced fertility and birth defects. Both occupational and environmental exposures to pesticides are important, as many are endocrine disruptors, which means that even very low-dose exposure levels may have measurable biological effects. The aim of this review was to summarize the knowledge collected between 2000 and 2020, to highlight new findings, and to further interpret the mechanisms that may associate pesticides with infertility, abnormal sexual maturation, and pregnancy complications associated with occupational, environmental and transplacental exposures. A summary of current pesticide production and usage legislation is also included in order to elucidate the potential impact on exposure profile differences between countries, which may inform prevention measures. Recommendations for the medical surveillance of occupationally exposed populations, which should be facilitated by the biomonitoring of reduced fertility, is also discussed.

Airport activities can contribute to the emission of ultrafine particles (UFPs) in the environment. The aim of our study is to assess the airborne levels of UFPs in a military airport and in the surrounding area. Four outdoor air samplings were carried out inside a military airport during flight activities, twelve nearby the military airport, five in an urban area, and one in a rural area. We used a portable Electrical Low Pressure Impactor to detect the particle number size distribution as well as the number concentration. Particles were chemically analyzed by field emission scanning electron microscopy. Inside the military airport, we observed an inverse correlation with distance from flight activities. The median UFP count ranged 3.7 × 103 -2.9 × 104 particles/cm3, and the highest UFP count was 4.0 × 106 particles/cm3 (during the taxi and take-off activities). Nearby the airport, UFP number concentrations were more elevated in the winter season and we did not observe a correlation with flight activities. Our results show a constant presence of UFPs regardless of the flight activities nearby the airport. Other anthropic sources may generate UFP concentrations significantly higher than those generated by airport activities

Abstract
The World Health Organization lists air pollution as one of the top five risks for developing chronic non-communicable disease, joining tobacco use, harmful use of alcohol, unhealthy diets and physical inactivity. This review focuses on how host defense mechanisms against adverse airborne exposures relate to the probable interacting and overlapping pathophysiological features of neurodegeneration and multiple chemical sensitivity. Significant long-term airborne exposures can contribute to oxidative stress, systemic inflammation, transient receptor subfamily vanilloid 1 (TRPV1) and subfamily ankyrin 1 (TRPA1) upregulation and sensitization, with impacts on olfactory and trigeminal nerve function, and eventual loss of brain mass. The potential for neurologic dysfunction, including decreased cognition, chronic pain and central sensitization related to airborne contaminants, can be magnified by genetic polymorphisms that result in less effective detoxification. Onset of neurodegenerative disorders is subtle, with early loss of brain mass and loss of sense of smell. Onset of MCS may be gradual following long-term low dose airborne exposures, or acute following a recognizable exposure. Upregulation of chemosensitive TRPV1 and TRPA1 polymodal receptors has been observed in patients with neurodegeneration, and chemically sensitive individuals with asthma, migraine and MCS. In people with chemical sensitivity, these receptors are also sensitized, which is defined as a reduction in the threshold and an increase in the magnitude of a response to noxious stimulation. There is likely damage to the olfactory system in neurodegeneration and trigeminal nerve hypersensitivity in MCS, with different effects on olfactory processing. The associations of low vitamin D levels and protein kinase activity seen in neurodegeneration have not been studied in MCS. Table 2 presents a summary of neurodegeneration and MCS, comparing 16 distinctive genetic, pathophysiological and clinical features associated with air pollution exposures. There is significant overlap, suggesting potential comorbidity. Canadian Health Measures Survey data indicates an overlap between neurodegeneration and MCS (p < 0.05) that suggests comorbidity, but the extent of increased susceptibility to the other condition is not established. Nevertheless, the pathways to the development of these conditions likely involve TRPV1 and TRPA1 receptors, and so it is hypothesized that manifestation of neurodegeneration and/or MCS and possibly why there is divergence may be influenced by polymorphisms of these receptors, among other factors.

Artikel 19(2) der neuen Biozidproduktverordnung (BiozidVO, 528/2012) führt aus dass die Bewertung […] die folgenden Faktoren berücksichtigen soll: "[…] (d) kumulative Wirkungen, (e) synergistische Wirkungen". Biozide Wirkstoffe sind häufig in vielen unterschiedlichen Produkten enthalten. Oft werden sie in unterschiedlichen Anwendungen eingesetzt. Dennoch werden in der Regel bei der Expositionsbeurteilung nur einzelne Verwendungen bewertet. Dies kann die tatsächlichen Konzentrationen der Wirkstoffe in der Umwelt unterschätzen. Wie können kumulative und synergistische Wirkungen bei der Biozidzulassung berücksichtigt werden? Derzeit gibt es nur wenige Hinweise zu dieser Aufgabenstellung in den "Technical Notes for Guidance on Product Evaluation" (TNsG on product evaluation, EU, 2002). Hinzu kommt, dass auch keine Anleitung verfügbar ist, wie bei der umweltbezogenen Risikobewertung von Biozidprodukten gleichzeitige Expositionen der Umwelt durch einen Wirkstoff zu berücksichtigen sind, die aus der Verwendung in verschiedenen Anwendungen und/oder in verschiedenen Produkten entstehen. Mit der Risikobewertung multipler simultaner Umweltexpositionen sind verschiedene rechtliche Fragen verbunden. Sie sind im Rahmen der vorliegenden rechtlichen Analyse angesprochen worden. Die Ergebnisse dieser Analyse sind anhand von Fallstudien im zweiten Teil des Berichts anschaulich diskutiert.

The aim of this study was to evaluate the effect of re-ensiling on the fermentability coefficient (FC), chemical composition and fermentation profile of untreated whole-crop sorghum silage after prolonged periods of environmental exposure. Treatments comprised eight times of exposure to the environment (0, 6, 12, 24, 48, 72, 96, and 120 h) and two procedures for conservation (conventional and re-ensiling) in a completely randomized design with two factors and three replicates. Experimental silos made of 12-L plastic buckets were used in trials. Silage nutritive value, fermentation profile, and dry mass (DM) losses were analyzed before and 90 days after re-ensiling. Regression analyses were performed, and ANOVA was used to compare means. The FC was higher than 45 even when the silage was exposed to air for 120 h before re-ensiling (59.2±2.54). Regression equations were fitted to the data with low accuracy (R2 < 0.47). Moreover, we observed that the main effect occurred between before and after re-ensiling, decreasing the contents of DM (42 to 37 %) and water-soluble carbohydrates (7.0 to 5.8 % DM), neutral detergent fiber (60.4 to 55.4 % DM), and acid detergent fiber (49.5 to 33.5 % DM), but increasing those of lactic acid (0.52 to 0.96 % DM) and ammoniacal nitrogen (1.58 to 2.51 % total N). The DM losses were linear with increasing times of air exposure; however, silage nutritive value and fermentation profile showed no disturbing changes for silage conservation and animal feeding.