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In this book, street-level bureaucracy scholars from South Asia, sub-Saharan Africa, the Middle East, and Latin America analyse the conditions that shape frontline work and citizens´ everyday experience of the state. Institutional factors such as political clientelism, resource scarcity, social inequality, job insecurity, and systemic corruption affect the way street-level bureaucrats enforce rules and implement policies. Inadvertently, they end up implementing inequities in citizens' access to rights and services —despite efforts to repair organisational deficiencies and broker relations between vulnerable citizens and a distant state. This book illuminates these realities and challenges and provides unique insights into critical themes such as resource scarcities, bureaucratic corruption, control practices and the complexities of dealing with vulnerable population groups

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats (SWOT). Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g., data management and representativeness) and common threats (e.g., economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others' experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet shall follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats (SWOT). Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g., data management and representativeness) and common threats (e.g., economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others' experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet shall follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

Preserving diversity of indigenous pig (Sus scrofa) breeds is a key factor to (i) sustain the pork chain (both at local and global scales) including the production of high-quality branded products, (ii) enrich the animal biobanking and (iii) progress conservation policies. Single nucleotide polymorphism (SNP) chips offer the opportunity for whole-genome comparisons among individuals and breeds. Animals from twenty European local pigs breeds, reared in nine countries (Croatia: Black Slavonian, Turopolje; France: Basque, Gascon; Germany: Schwabisch-Hällisches Schwein; Italy: Apulo Calabrese, Casertana, Cinta Senese, Mora Romagnola, Nero Siciliano, Sarda; Lithuania: Indigenous Wattle, White Old Type; Portugal: Alentejana, Bísara; Serbia: Moravka, Swallow-Bellied Mangalitsa; Slovenia: Krškopolje pig; Spain: Iberian, Majorcan Black), and three commercial breeds (Duroc, Landrace and Large White) were sampled and genotyped with the GeneSeek Genomic Profiler (GGP) 70 K HD porcine genotyping chip. A dataset of 51 Wild Boars from nine countries was also added, summing up to 1186 pigs (~ 49 pigs/ breed). The aim was to: (i) investigate individual admixture ancestries and (ii) assess breed traceability via discriminant analysis on principal components (DAPC). Albeit the mosaic of shared ancestries found for Nero Siciliano, Sarda and Moravka, admixture analysis indicated independent evolvement for the rest of the breeds. High prediction accuracy of DAPC mark SNP data as a reliable solution for the traceability of breed-specific pig products. ; This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 634476 for the project with acronym TREASURE. The content of this article reflects only the authors' view and the European Union Agency is not responsible for any use that may be made of the information it contains. MŠ and MČP received core-financing by the Slovenian Research Agency (grant number P4-0133). ; info:eu-repo/semantics/publishedVersion

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats (SWOT). Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g., data management and representativeness) and common threats (e.g., economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others' experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet shall follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

13 Pág. ; Preserving diversity of indigenous pig (Sus scrofa) breeds is a key factor to (i) sustain the pork chain (both at local and global scales) including the production of high-quality branded products, (ii) enrich the animal biobanking and (iii) progress conservation policies. Single nucleotide polymorphism (SNP) chips offer the opportunity for whole-genome comparisons among individuals and breeds. Animals from twenty European local pigs breeds, reared in nine countries (Croatia: Black Slavonian, Turopolje; France: Basque, Gascon; Germany: Schwabisch-Hällisches Schwein; Italy: Apulo Calabrese, Casertana, Cinta Senese, Mora Romagnola, Nero Siciliano, Sarda; Lithuania: Indigenous Wattle, White Old Type; Portugal: Alentejana, Bísara; Serbia: Moravka, Swallow-Bellied Mangalitsa; Slovenia: Krškopolje pig; Spain: Iberian, Majorcan Black), and three commercial breeds (Duroc, Landrace and Large White) were sampled and genotyped with the GeneSeek Genomic Profiler (GGP) 70 K HD porcine genotyping chip. A dataset of 51 Wild Boars from nine countries was also added, summing up to 1186 pigs (~ 49 pigs/breed). The aim was to: (i) investigate individual admixture ancestries and (ii) assess breed traceability via discriminant analysis on principal components (DAPC). Albeit the mosaic of shared ancestries found for Nero Siciliano, Sarda and Moravka, admixture analysis indicated independent evolvement for the rest of the breeds. High prediction accuracy of DAPC mark SNP data as a reliable solution for the traceability of breed-specific pig products. ; This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 634476 for the project with acronym TREASURE. The content of this article reflects only the authors' view and the European Union Agency is not responsible for any use that may be made of the information it contains. MŠ and MČP received core-financing by the Slovenian Research Agency (grant number P4-0133). ; Peer reviewed

We report the detection of three RR Lyrae (RRL) stars (two RRc and one RRab) in the ultra-faint dwarf (UFD) galaxy Centaurus I (Cen I) and two Milky Way (MW) δ Scuti/SX Phoenicis stars based on multi-epoch giz DECam observations. The two RRc stars are located within two times the half-light radius (rh) of Cen I, while the RRab star (CenI-V3) is at ∼6 rh. The presence of three distant RRL stars clustered this tightly in space represents a 4.7σ excess relative to the smooth distribution of RRL in the Galactic halo. Using the newly detected RRL stars, we obtain a distance modulus to Cen I of μ0 = 20.354 ± 0.002 mag (σ = 0.03 mag), a heliocentric distance of De = 117.7 ± 0.1 kpc (σ = 1.6 kpc), with systematic errors of 0.07 mag and 4 kpc. The location of the Cen I RRL stars in the Bailey diagram is in agreement with other UFD galaxies (mainly Oosterhoff II). Finally, we study the relative rate of RRc+RRd (RRcd) stars (fcd) in UFD and classical dwarf galaxies. The full sample of MW dwarf galaxies gives a mean of fcd = 0.28. While several UFD galaxies, such as Cen I, present higher RRcd ratios, if we combine the RRL populations of all UFD galaxies, the RRcd ratio is similar to the one obtained for the classical dwarfs (fcd ∼ 0.3). Therefore, there is no evidence for a different fraction of RRcd stars in UFD and classical dwarf galaxies. ; Fermilab LDRD project L2019-011 NASA Fermi Guest Investigator Program Cycle 9 91201 United States Department of Energy (DOE) National Science Foundation (NSF) Spanish Government UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) UK Research & Innovation (UKRI) Higher Education Funding Council for England (HEFCE) National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign University of Chicago Ohio State University Mitchell Institute for Fundamental Physics and Astronomy at Texas AM University Financiadora de Inovacao e Pesquisa (Finep) Fundaco Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Spanish Government German Research Foundation (DFG) Dark Energy Survey United States Department of Energy (DOE) University of California at Santa Cruz University of Cambridge, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas-Madrid University of Chicago, University College London DES-Brazil Consortium University of Edinburgh ETH Zurich United States Department of Energy (DOE) University of Chicago University of Illinois at Urbana-Champaign Institut de Ciencies de l'Espai (IEEC/CSIC) Institut de Fisica d'Altes Energies, Lawrence Berkeley National Laboratory Ludwig-Maximilians Universitat Munchen associated Excellence Cluster Universe University of Michigan, NSF's NOIRLab University of Nottingham Ohio State University OzDES Membership Consortium University of Pennsylvania University of Portsmouth Stanford University United States Department of Energy (DOE) Stanford University University of Sussex Texas AM University United States Department of Energy (DOE) DE-AC02-07CH11359 ; Versión publicada - versión final del editor

Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope with these usually pro-inflammatory signals are poorly understood. Here, we show that innate immune memory promotes anti-inflammatory homeostasis, using as model strains of the commensal bacterium Lactiplantibacillus plantarum. Priming of monocytes/macrophages with bacteria, especially in its live form, enhances bacterial intracellular survival and decreases the release of pro-inflammatory signals to the environment, with lower production of TNF and higher levels of IL-10. Analysis of the transcriptomic landscape of these cells shows downregulation of pathways associated with the production of reactive oxygen species (ROS) and the release of cytokines, chemokines and antimicrobial peptides. Indeed, the induction of ROS prevents memory-induced bacterial survival. In addition, there is a dysregulation in gene expression of several metabolic pathways leading to decreased glycolytic and respiratory rates in memory cells. These data support commensal microbe-specific metabolic changes in innate immune memory cells that might contribute to homeostasis in the gut. ; Supported by grants from the Spanish Ministry of Science, Innovation and Universities (MCIU) co-financed with FEDER funds (RTI2018-096494-B-100 to JA; BFU2016-76872-R to EB; AGL2017-86757-R to LA; SAF2015-73549-JIN to HR; SAF2016–77433-R and PID2019-110240RB-I00 to RPR). AP is supported by a Postdoctoral Fellowship from the Basque Government. DB and TMM are recipients of MCIU FPI fellowships. APC is a recipient of a fellowship from the University of the Basque Country. LA and RPR are supported by the Ramon y Cajal program from the Spanish Ministry of Economy and Competitiveness. We thank the MCIU for the Severo Ochoa Excellence accreditation (SEV-2016-0644), the Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs) and the Innovation Technology Department of the Bizkaia Province. This work was further supported by grants from the Jesús de Gangoiti Barrera Foundation. ; Peer reviewed

The emergence of Zika virus (ZIKV) represents a threat with consequences on maternal and children's health. We aimed to assess the clinical and epidemiological characteristics of pregnant women returning from ZIKV affected areas, and the effects of maternal ZIKV infection on birth outcomes and children's health. This was a hospital-based prospective observational study conducted at the Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Barcelona, Spain, from January 2016 to February 2020. One hundred and ninety-five pregnant women who had travelled to ZIKV affected areas during pregnancy were recruited. Four women (2.1%) had a confirmed ZIKV infection, 40 women (20.5%) a probable infection, and 151 (77.4%) were negative for ZIKV. Among the ZIKV confirmed cases, a pregnant woman suffered a miscarriage, highly plausible to be associated with ZIKV infection. Brain cysts and microcalcifications were detected in 7% of fetuses or infants from women with confirmed or probable ZIKV infection. Neurodevelopmental delay in the language function was found in 33.3% out of the 21 children evaluated. These findings contribute to the understanding of ZIKV prevalence estimates, and the impact of maternal ZIKV infection on pregnancy outcomes and children's health. Results highlight the importance of long-term surveillance in pregnant travellers and their children. ; This work was supported by the Government of Spain [grant number PI16/0123, ISCIII-AES Proyectos de Investigación en Salud, 2016]; a predoctoral fellowship from "la Caixa" Foundation (ID 100010434) [fellowship LCF/BQ/ES17/11600006]; the Ministry of Science, Innovation and Universities, Government of Spain through a Ramon y Cajal Grant [RYC-2013-14,512]; RICET, a Tropical Disease Cooperative Research Network in Spain [RD12/0018/0010] cofounded by ISCIII and the Fondo Europeo de Desarrollo Regional (FEDER); the Departament d'Universitats I Recerca de la Generalitat de Catalunya, Spain, AGAUR [grant 2017SGR924]; and ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. ; Sí

T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse. Therefore, there is an unmet medical need for novel therapies in T-PLL. As the chemokine receptor CCR7 is a molecule expressed in a wide range of malignancies and relevant in many tumor processes, the present study addressed the biologic role of this receptor in T-PLL. Furthermore, we elucidated the mechanisms of action mediated by an anti-CCR7 monoclonal antibody (mAb) and evaluated whether its anti-tumor activity would warrant development towards clinical applications in T-PLL. Our results demonstrate that CCR7 is a prognostic biomarker for overall survival in T-PLL patients and a functional receptor involved in the migration, invasion, and survival of leukemic cells. Targeting CCR7 with a mAb inhibited ligand-mediated signaling pathways and induced tumor cell killing in primary samples. In addition, directing antibodies against CCR7 was highly effective in T-cell leukemia xenograft models. Together, these findings make CCR7 an attractive molecule for novel mAb-based therapeutic applications in T-PLL, a disease where recent drug screen efforts and studies addressing new compounds have focused on chemotherapy or small molecules. ; Funding for this work was by grant PI015/02085 and PI18/01163 from the Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo, Spain to CMC who was also cofinanced by FEDER funds. CCM and FT were supported by RTC-2015-3318-1 (Ministerio de Economía y Competitividad, Spain). MH was funded by the German Research Foundation (DFG; HE3553/ 4–2) as part of the collaborative research group on mature T-cell lymphomas, "CONTROL-T" (FOR1961). The José Carreras Leukemia Foundation (03F/2016), the Köln Fortune Program, and the Fritz Thyssen foundation (10.15.2.034MN) supported MH and AS. The Köln Fortune Program also supported LW. SM was supported by the Finnish Cancer Organizations, the Finnish Cancer Institute, Academy of Finland and the Sigrid Juselius Foundation. SM and MH are supported by the ERAPerMed program 'JAK- STAT-TARGET'. MLT was granted by SAF2016–75442-R (Agencia Estatal de Investigación/ European Regional Development Fund, European Union, Spain).

The monitoring of antimicrobial resistance (AMR) in bacterial pathogens of animals is not currently coordinated at European level. To fill this gap, experts of the European Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet). In this study, we (i) identified national monitoring systems for AMR in bacterial pathogens of animals (both companion and food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures and operations, and (iii) analyzed their respective strengths, weaknesses, opportunities and threats. Twelve countries reported having at least one national monitoring system in place, representing an opportunity to launch EARS-Vet, but highlighting important gaps in AMR data generation in Europe. In total, 15 national monitoring systems from 11 countries were described and analyzed. They displayed diverse structures and operations, but most of them shared common weaknesses (e.g. data management and representativeness) and common threats (e.g. economic vulnerability and data access), which could be addressed collectively under EARS-Vet. This work generated useful information to countries planning to build or improve their system, by learning from others' experience. It also enabled to advance on a pragmatic harmonization strategy: EARS-Vet would follow the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards, collect quantitative data and interpret AMR data using epidemiological cut-off values.

The Malalmuerzo cave (Moclín, Granada, Spain) has been known since the 1980s for its archaeological remains and rock art, dated to the Neolithic and the Solutrean periods respectively. However, following thirty years of neglect, our team carried out a brief archaeological intervention after looters destroyed parts of the sediment fill of the cave. The refreshing of disturbed surfaces and the examination of a small undisturbed profile produced many archaeological remains attributed to several Magdalenian levels. The levels partially covered the depiction of a red horse, which probably dates to the Solutrean period.

We present a map of the total intrinsic reddening across similar or equal to 34 deg(2) of the Small Magellanic Cloud (SMC) derived using optical (ugriz) and near-infrared (IR; YJK(s)) spectral energy distributions (SEDs) of background galaxies. The reddening map is created using a subsample of 29 274 galaxies with low levels of intrinsic reddening based on the LEPHARE chi(2) minimization SED-fitting routine. We find statistically significant enhanced levels of reddening associated with the main body of the SMC compared with regions in the outskirts [Delta E(B - V) similar or equal to 0.3 mag]. A comparison with literature reddening maps of the SMC shows that, after correcting for differences in the volume of the SMC sampled, there is good agreement between our results and maps created using young stars. In contrast, we find significant discrepancies between our results and maps created using old stars or based on longer wavelength far-IR dust emission that could stem from biased samples in the former and uncertainties in the far-IR emissivity and the optical properties of the dust grains in the latter. This study represents one of the first large-scale categorizations of extragalactic sources behind the SMC and as such we provide the LEPHARE outputs for our full sample of similar to 500 000 sources. ; European Research Council (ERC) 682115 ERC consolidator grant project STARKEY 615604 National Science Foundation (NSF) AST 1655677 Spanish Ministry for Science, Innovation and Universities AYA2016-81065-C2-2 European Commission AYA2016-81065-C2-2 State Agency for Research of the Spanish MCIU through the 'Centre of Excellence Severo Ochoa' award SEV-2017-0709 PGC2018-095049B-C21 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT PIA/BASAL AFB-170002 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1170364 Science and Engineering Research Board, India through a Ramanujan Fellowship UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) VISTA at the La Silla Paranal Observatory 179.B-2003 United States Department of Energy (DOE) National Science Foundation (NSF) Spanish Government UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) Higher Education Funding Council for England National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign Kavli Institute of Cosmological Physics at the University of Chicago Ohio State University Ciencia Tecnologia e Inovacao (FINEP) Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Ministerio da Ciencia, Tecnologia e Inovacao German Research Foundation (DFG) Mitchell Institute for Fundamental Physics and Astronomy at Texas AM University United States Department of Energy (DOE) University of Chicago University of California at Santa Cruz University of Cambridge Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas-Madrid University of Chicago University College London DES-Brazil Consortium University of Edinburgh ETH Zurich United States Department of Energy (DOE) University of Chicago University of Illinois atUrbanaChampaign Institut de Ciencies de l'Espai (IEEC/CSIC) Institut de Fisica d'Altes Energies United States Department of Energy (DOE) Ludwig-Maximilians Universitat Munchen associated Excellence Cluster Universe University of Michigan System National Science Foundation (NSF) NSF - Directorate for Mathematical & Physical Sciences (MPS) University of Nottingham Ohio State University University of Pennsylvania University of Portsmouth Stanford University United States Department of Energy (DOE) Stanford University University of Sussex Texas AM University

Resumen: Se considera determinante para detener la rápida propagación del COVID-19, lograr adherencia de la población a las políticas públicas preventivas indicativas de comportamiento. Las recomendaciones han sido diferentes en los distintos países y han arrojado resultados variados en términos de prevalencia del COVID-19 (Montreal Behavioural Medicine Centre, 2020). El Estudio International COVID- 19 Awareness and Responses Evaluation Study (ICARE) asociado a las políticas de salud pública busca conocer si es loable optimizar las estrategias aplanando la curva de infección por COVID-19. Entre los hallazgos se relevó una preocupación central en el 80 % de los participantes de que un miembro de la familia no conviviente o allegados se infectará de COVID-19. Las respuestas exhibían mayor desazón por los impactos potenciales del COVID-19 en otras personas cercanas que en sí mismos. Estos hallazgos podrían dar cuenta de conductas de solidaridad y prosociales muy relevantes a la hora de diseñar campañas de prevención y desarrollo estratégico de políticas públicas, fomentando y haciendo foco en el cuidado del otro. ; Abstract: In stopping the rapid spread of COVID-19, it is essential for the population to adhere to preventive state policies. The recommendations have been different in different nations and have yielded mixed results (Montreal Behavioral Medicine Center, 2020). The International COVID-19 study Awareness and Response Assessment Study (ICARE) -regarding public health policies- seeks to know the viability of optimising strategies which intend to flatten the COVID-19 infection curve. Among the findings, a central concern was revealed in 80% of the participants: Fear of close friends or family members outside the household being infected with COVID-19. Responses exhibited greater unease about the potential impacts of COVID-19 on others close to them than on themselves. These findings could account for prosocial and altruistic behaviours which are highly relevant to the design of prevention campaigns and state policies focusing on caring for others.