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This is the final version. Available on open access from De Gruyter via the DOI in this record ; The integration of artificial intelligence (AI) systems in the daily life greatly increases the amount of data generated and processed. In addition to the large computational power required, the hardware needs to be compact and energy efficient. One promising approach to fulfill those requirements is phase-change material based photonic neuromorphic computing that enables in-memory computation and a high degree of parallelization. In the following, we present an optimized layout of a photonic tensor core (PTC) which is designed to perform real valued matrix vector multiplications and operates at telecommunication wavelengths. We deploy the well-studied phase-change material Ge2Sb2Te5 (GST) as an optical attenuator to perform single positive valued multiplications. In order to generalize the multiplication to arbitrary real factors, we develop a novel symmetric multiplication unit which directly includes a reference-computation branch. The variable GST attenuator enables a modulation depth of 5 dB over a wavelength range of 100 nm with a wavelength dependency below 0.8 dB. The passive photonic circuit itself ensures equal coupling to the main-computation and reference-computation branch over the complete wavelength range. For the first time, we integrate wavelength multiplexers (MUX) together with a photonic crossbar array on-chip, paving the way towards fully integrated systems. The MUX are crucial for the PTC since they enable multiple computational channels in a single photonic crossbar array. We minimize the crosstalk between the channels by designing Bragg scattering based MUX. By cascading, we achieve an extinction ratio larger than 61 dB while the insertion loss is below 1 dB. ; Deutsche Forschungsgemeinschaft (DFG) ; European Research Council (ERC) ; European Union Horizon 2020 ; Studienstiftung des deutschen Volkes

Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7% of men, and its prevalence increased with age (per-year odds ratio (OR) = 1.13, 95% confidence interval (CI) = 1.12-1.15; P < 2 × 10(-16)), reaching 18.7% among men over 80 years old. mLOY was associated with current smoking (OR = 2.35, 95% CI = 1.82-3.03; P = 5.55 × 10(-11)), but the association weakened with years after cessation. mLOY was not consistently associated with overall or specific cancer risk (for example, bladder, lung or prostate cancer) nor with cancer survival after diagnosis (multivariate-adjusted hazard ratio = 0.87, 95% CI = 0.73-1.04; P = 0.12). In a genome-wide association study, we observed the first example of a common susceptibility locus for genetic mosaicism, specifically mLOY, which maps to TCL1A at 14q32.13, marked by rs2887399 (OR = 1.55, 95% CI = 1.36-1.78; P = 1.37 × 10(-10)). ; This project has been funded in whole or in part with federal funds from the National Cancer Institute, US National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services nor does mention of trade names, commercial products or organizations imply endorsement by the US government.

© 2018 Elsevier Ltd Ecosystem services (the benefits to humans from ecosystems) are estimated globally at $125 trillion/year [1, 2]. Similar assessments at national and regional scales show how these services support our lives [3]. All valuations recognize the role of biodiversity, which continues to decrease around the world in maintaining these services [4, 5]. The giant panda epitomizes the flagship species [6]. Its unrivalled public appeal translates into support for conservation funding and policy, including a tax on foreign visitors to support its conservation [7]. The Chinese government has established a panda reserve system, which today numbers 67 reserves [8, 9]. The biodiversity of these reserves is among the highest in the temperate world [10], covering many of China's endemic species [11]. The panda is thus also an umbrella species [12]—protecting panda habitat also protects other species. Despite the benefits derived from pandas, some journalists have suggested that it would be best to let the panda go extinct. With the recent downlisting of the panda from Endangered to Vulnerable, it is clear that society's investment has started to pay off in terms of panda population recovery [13, 14]. Here, we estimate the value of ecosystem services of the panda and its reserves at between US$2.6 and US$6.9 billion/year in 2010. Protecting the panda as an umbrella species and the habitat that supports it yields roughly 10–27 times the cost of maintaining the current reserves, potentially further motivating expansion of the reserves and other investments in natural capital in China. Wei et al. estimate that the value of ecosystem services of the giant panda and its nature reserves was US$2.6–US$6.9 billion/year in 2010. Protecting the panda and its habitat yields roughly 10–27 times the cost of maintaining the current reserves, potentially motivating expansion of the reserves and other investments in natural capital in China.