Suchergebnisse

Introduction - Arnd Schneider & Christopher WrightAgit-kino: Iteration No.2 - Craig Campbell, University of Texas at Austin, USAEntrada Prohibida (Forbidden Entry) - Juan Orrantia, University of Witwatersrand, South Africa In Conversation with Christopher Wright - Anthony Luvera, Independent Australian Artsist, Writer and Educator based in London, UKTraversing Art Practices and Anthropology: Notes on Ambiguity and Epistemological Uncertainty - Thera Mjaaland, Independent Photographer and Social Anthropologist, NorwaySurgery Lessons - Christina Lammer, University of Applied Arts Vienna, AustriaA Word is Not Always Just a Word, Sometimes It is an Image - Kathryn Ramey, Emerson College, USAOut of Hand: Reflections on Elsewhereness - Robert Willim, Lund University, SwedenOn Collections and Collectivity - Brad Butler & Karen Mizr, Independent Artists and Filmmakers, UKIn Conversation with Christopher Wright - Raul Ortega Ayala, Independent Artist, MexicoIn-between - Jennifer Deger, The Australian National University, AustraliaAn Imaginary Line: Active Pass to IR9 - Kate Hennesey, Simon Fraser University, CanadaDancing in the Abyss - Living with Liminality - Ruth Jones, Artist and Curator based in Wales, UKIn Conversation with Helen Lundbye Petersen - Yvette Brackman, Independent Artist, DenmarkWith(In) Each Other: Sensorial Practices in Recent Audiovisual Work - Laurent Van Lancker, Freie Universitat Berlin, GermanyIn Praise of Slow Motion - Caterina Pasqualino, researcher, CNRS/LAIOS, FranceSky-larks: an Exploration of a Collaboration Between Art, Anthropology and Science - Rupert Cox, University of Manchester, UK & Andrew Carlyle, London College of Communication, University of the Arts London, UKBibliographyIndex

This book explores the complex relationship that the corporate world has with climate change and examines the different ways that corporations engage with the climate crisis. Topics include climate change as business risk, corporate climate politics, the role of justification and compromise, managerial identity, and emotional reactions to climate change.

This timely book offers the first critical examination of World Bank policy reforms and initiatives during the past decade.

The catastrophic consequences of climate change are now evident with extreme weather events impacting communities and ecosystems. Against calls within civil society for dramatic decarbonisation, the continued expansion of the fossil fuel industry is constructed by governments and business as 'common sense'. By analysing the political process surrounding the 2016 and 2017 coral bleaching of the Great Barrier Reef, we show how a fossil fuel hegemony has been upheld against the counter-hegemonic forces of environmental critique and the catastrophic bleaching events. By distinguishing between politics (i.e. strategies, practices and discourses) and the political (i.e. the antagonism constitutive of societies), we explain what different hegemonic practices achieve in the process of establishing and defending hegemony. In our case, this resulted in downplaying emissions mitigation and emphasising local climate change adaptation. Through the political process, business solutions and self-regulation were presented as the logical response to the climate crisis.

Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://pubmed.ncbi.nlm.nih.gov/30930126/ ; Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large cohort of subjects with increased risk for diabetes and identified two subjects with impaired glucose tolerance carrying common, heterozygous, missense mutations in the PDX1 coding region leading to single amino acid exchanges (P33T, C18R) in its transactivation domain. We generated iPSCs from patients with heterozygous PDX1(P33T/)(+), PDX1(C18R/+) mutations and engineered isogenic cell lines carrying homozygous PDX1(P33T/P33T), PDX1(C18R/C18R) mutations and a heterozygous PDX1 loss-of-function mutation (PDX1(+/-)). Results: Using an in vitro beta-cell differentiation protocol, we demonstrated that both, heterozygous PDXP33T/+, PDX1(C18R/+)and homozygous PDX1(P33T/P33T), PDX1(C18R/C18R) mutations impair beta-cell differentiation and function. Furthermore, PDX1(+/-) and PDX1(P33T/P33T )mutations reduced differentiation efficiency of pancreatic progenitors (PPs), due to downregulation of PDX1 -bound genes, including transcription factors MNX1 and PDX1 as well as insulin resistance gene CES1. Additionally, both PDX1(P33T/+ )and PDX1(P33T/P33T) mutations in PPs reduced the expression of PDX1-bound genes including the long-noncoding RNA, MEG3 and the imprinted gene NNAT, both involved in insulin synthesis and secretion. Conclusions: Our results reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and beta-cell function and contribute to the predisposition for diabetes. (C) 2019 The Authors. Published by Elsevier GmbH. ; We thank A. Malinowski and K. Y for comments and discussions and A. Theis, B. Vogel, A. Bastidas-Ponce, M. Bamberger and K. Diemer for their technical support. We also thank Stefan Krebs and the sequencing unit of the Laboratory of Functional Genome Analysis (LAFUGA) at the Gene Center of the LMU. This work was funded in part by the German Center for Diabetes Research (DZD e.V.), by the European Union's Seventh Framework Programme for Research, Technological Development and Demonstration under grant agreement No. 602587 (http://www.hum-en.eu/), and by funds of the Helmholtz Association for the future topic "Aging and Metabolic programming" (AMPro).

Climate change poses a significant threat to future social and economic activities. This article seeks to understand how corporations respond to climate uncertainties and threats through the performance of different 'risks', including market, reputational, regulatory and physical risks. In doing this, we demonstrate how these risks are performative and political. Based on interviews and document analysis, we show how climate change risks are naturalized within market conventions through processes of reiterating climate change as risk, codifying the risk in monetary value, entangling the risk in market conventions and cementing the frame through political activities. We also show how these risk frames have political effects in that they fail to fully account for, or represent, the complexities of climate change. Indeed, the social and natural consequences of climate change undermine the risk models that seek to explain and predict these events. The consequences of these 'misfires' highlight the political nature of risk frames in that their effects are unequally distributed among less powerful actors. Importantly, however, these misfires also have the potential to provide space for new interventions in responding to climate change.