Suchergebnisse

Introduction: Acquired hemophilia
A is a hemorrhagic disorder produced by autoantibodies
directed against circulating factor VIII. Bleeding often
appears in the skin, muscles, the retroperitoneal area, and
the gastrointestinal tract; however, it is not frequent
regarding occurrence in the oral cavity. Case report: We
report an unusual case of an elderly woman in the eighth
decade of life with AHA characterized by painful blood
blisters in the oral cavity. The diagnosis was established
with a high activated partial thromboplastin time (aPTT),
normal prothrombin time and elevated levels of factor VIII
inhibitor (FVIII: C). The patient was treated with the
activated recombinant factor VII and prednisone associated
with cyclophosphamide during six weeks. Drugs were stopped
when normalization of aPTT was identified. Discussion: The
diagnosis of HAA is complicated because there is no family
history of bleeding and its autoimmune etiopathogenesis.
Furthermore, the clinical presentation is due to
spontaneous and severe bleeding associated with a prolonged
time of thromboplastin. Conclusion: The initial
identification and the application of the treatment are
essential to reduce the mortality rate of those patients
affected.

Twelve non-replicate Acinetobacter baumannii isolates from five European hospitals, Kuwait, and the US military healthcare system collected between 1980 and 2005 revealed a new clone, CC32. These included representative isolates of outbreaks/cross-infections. Antimicrobial susceptibility and carbapenem-resistant genetic traits varied. The widespread occurrence, the association with an outbreak and the carbapenem resistance indicate that CC32 has epidemic potential.

O uso de drogas de abuso vem tomando proporções cada vez maiores na sociedade. A cada ano é notável o surgimento de novas substâncias com capacidade de provocar dependência física ou psicológica. O Instituto de Polícia Científica da Paraíba é um órgão pertencente à Polícia Civil do Estado que possui um setor responsável pela análise de drogas apreendidas. Neste contexto, o presente estudo teve como objetivo criar um perfil de drogas de abuso admitidas no IPC-JP entre os meses de janeiro a novembro de 2017. A coleta de dados se deu através da análise de 1851 laudos referentes às admissões de drogas de abuso, onde foram extraídas as informações necessárias à pesquisa. Foi possível traçar um panorama contendo informações a respeito da incidência de drogas, dos seus métodos de análises, do trabalho da polícia e da ação do Instituto, demonstrando através dos dados a situação atual e as perspectivas de avanço nas políticas de prevenção ao uso de drogas. Os resultados apontam a maconha como à droga mais apreendida, seguida pela cocaína. As apreensões de cocaína em forma de pedra representam quase que o dobro do número de apreensões da forma em pó. Em 87% das análises o esquema analítico seguia as recomendações do SWGDRUG. Os resultados apresentados se destinam a coadjuvar com programas e ações destinados a prevenção e combate a utilização e tráfico de drogas.

11 págs.; 6 figs.; 5 tabs. ; © 2015 AIP Publishing LLC. We report results from a joint theoretical and experimental investigation into electron scattering from the important organic species phenol (C6H5OH). Specifically, differential cross sections (DCSs) have been measured and calculated for the electron-impact excitation of the electronic states of C6H5OH. The measurements were carried out at energies in the range 15-40 eV, and for scattered-electron angles between 10 and 90. The energy resolution of those experiments was typically ∼80 meV. Corresponding Schwinger multichannel method with pseudo-potentials calculations, with and without Born-closure, were also performed for a sub-set of the excited electronic-states that were accessed in the measurements. Those calculations were conducted at the static exchange plus polarisation (SEP)-level using a minimum orbital basis for single configuration interaction (MOBSCI) approach. Agreement between the measured and calculated DCSs was typically fair, although to obtain quantitative accord, the theory would need to incorporate even more channels into the MOBSCI. ; This research was supported by the Australian and Brazilian Governmental Funding Agencies (ARC, CNPq and CAPES). D.B.J. thanks the ARC for a Discovery Early Career Researcher Award. R.F.C.N. acknowledges CNPq and Flinders University for financial assistance, while H.V.D. acknowledges CAPES and Flinders. M.J.B. thanks CNPq for his "Special Visiting Professor" award. E.M.O., R.F.C., M.T.N.V., and M.A.P.L. acknowledge financial support from FAPESP, while R.F.C., M.T.N.V., M.H.F.B., M.C.A.L., and M.A.P.L. acknowledge financial support from CNPq. K.L.N. thanks CNPq for an "Attracting Young Talent Grant" under the "Science Without Borders" program. G.G. acknowledges financial support from MINECO (FIS2012-31230) and COST (MP1002, CM1301). ; Peer Reviewed

Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Novel species of fungi described in this study include those from various countries as follows: Angola, Gnomoniopsis angolensis and Pseudopithomyces angolensis on unknown host plants. Australia, Dothiora corymbiae on Corymbia citriodora, Neoeucasphaeria eucalypti (incl. Neoeucasphaeria gen. nov.)on Eucalyptus sp., Fumagopsis stellae on Eucalyptus sp., Fusculina eucalyptorum (incl. Fusculinaceae fam. nov.) on Eucalyptus socialis, Harknessia corymbiicola on Corymbia maculata, Neocelosporium eucalypti (incl. Neocelosporium gen. nov., Neocelosporiaceae fam. nov. and Neocelosporiales ord. nov.) on Eucalyptus cyanophylla, Neophaeomoniella corymbiae on Corymbia citriodora, Neophaeomoniella eucalyptigena on Eucalyptus pilularis, Pseudoplagiostoma corymbiicola on Corymbia citriodora, Teratosphaeria gracilis on Eucalyptus gracilis, Zasmidium corymbiae on Corymbia citriodora. Brazil, Calonectria hemileiae on pustules of Hemileia vastatrix formed on leaves of Coffea arabica, Calvatia caatinguensis on soil, Cercospora solani-betacei on Solanum betaceum, Clathrus natalensis on soil, Diaporthe poincianellae on Poincianella pyramidalis, Geastrum piquiriunense on soil, Geosmithia carolliae on wing of Carollia perspicillata, Henningsia resupinata on wood, Penicillium guaibinense from soil, Periconia caespitosa from leaf litter, Pseudocercospora styracina on Styrax sp., Simplicillium filiforme as endophyte from Citrullus lanatus, Thozetella pindobacuensis on leaf litter, Xenosonderhenia coussapoae on Coussapoa floccosa. ; Canary Islands (Spain), Orbilia amarilla on Euphorbia canariensis. Cape Verde Islands, Xylodon jacobaeus on Eucalyptus camaldulensis. Chile, Colletotrichum arboricola on Fuchsia magellanica. Costa Rica, Lasiosphaeria miniovina ontreebranch. Ecuador, Ganoderma chocoense ontreetrunk. France, Neofitzroyomyces nerii (incl. Neofitzroyomyces gen. nov.) on Nerium oleander. Ghana, Castanediella tereticornis on Eucalyptus tereticornis, Falcocladium africanum on Eucalyptus brassiana, Rachicladosporium corymbiae on Corymbia citriodora. Hungary, Entoloma silvae-frondosae in Carpinus betulus-Pinus sylvestris mixedforest. Iran, Pseudopyricularia persiana on Cyperus sp. Italy, Inocybe roseascens onsoilinmixedforest. Laos, Ophiocordyceps houaynhangensis on Coleoptera larva. Malaysia, Monilochaetes melastomae on Melastoma sp. Mexico, Absidia terrestris fromsoil. Netherlands, Acaulium pannemaniae, Conioscypha boutwelliae, Fusicolla septimanifiniscientiae, Gibellulopsis simonii, Lasionectria hilhorstii, Lectera nordwiniana, Leptodiscella rintelii, Parasarocladium debruynii and Sarocladium dejongiae (incl. Sarocladiaceae fam. nov.) fromsoil. New Zealand, Gnomoniopsis rosae on Rosa sp. and Neodevriesia metrosideri on Metrosideros sp. Puerto Rico, Neodevriesia coccolobae on Coccoloba uvifera, Neodevriesia tabebuiae and Alfaria tabebuiae on Tabebuia chrysantha . Russia, Amanita paludosa on bogged soil in mixed deciduous forest, Entoloma tiliae in forest of Tilia × europaea, Kwoniella endophytica on Pyrus communis. ; South Africa, Coniella diospyri on Diospyros mespiliformis, Neomelanconiella combreti (incl. Neomelanconiellaceae fam. nov. and Neomelanconiella gen. nov.)on Combretum sp., Polyphialoseptoria natalensis on unidentified plant host, Pseudorobillarda bolusanthi on Bolusanthus speciosus, Thelonectria pelargonii on Pelargonium sp. Spain, Vermiculariopsiella lauracearum and Anungitopsis lauri on Laurus novocanariensis, Geosmithia xerotolerans from a darkened wall of a house, Pseudopenidiella gallaica on leaf litter. Thailand, Corynespora thailandica on wood, Lareunionomyces loeiensis on leaf litter, Neocochlearomyces chromolaenae (incl. Neocochlearomyces gen. nov.) on Chromolaena odorata, Neomyrmecridium septatum (incl. Neomyrmecridium gen. nov .), Pararamichloridium caricicola on Carex sp., Xenodactylaria thailandica (incl. Xenodactylariaceae fam. nov. and Xenodactylaria gen. nov.), Neomyrmecridium asiaticum and Cymostachys thailandica fromunidentifiedvine. USA, Carolinigaster bonitoi (incl. Carolinigaster gen. nov.)fromsoil, Penicillium fortuitum from house dust, Phaeotheca shathenatiana (incl. Phaeothecaceae fam. nov.) from twig and cone litter, Pythium wohlseniorum from stream water, Superstratomyces tardicrescens from human eye, Talaromyces iowaense from officeair. Vietnam, Fistulinella olivaceoalba onsoil. Morphological and culture characteristics along with DNA barcodes are provided Novel species of fungi described in this study include those from various countries as follows: Angola, Gnomoniopsis angolensis and Pseudopithomyces angolensis on unknown host plants. Australia, Dothiora corymbiae on Corymbia citriodora, Neoeucasphaeria eucalypti (incl. Neoeucasphaeria gen. nov.)on Eucalyptus sp., Fumagopsis stellae on Eucalyptus sp., Fusculina eucalyptorum (incl. Fusculinaceae fam. nov.) on Eucalyptus socialis, Harknessia corymbiicola on Corymbia maculata, Neocelosporium eucalypti (incl. Neocelosporium gen. nov., Neocelosporiaceae fam. nov. and Neocelosporiales ord. nov.) on Eucalyptus cyanophylla, Neophaeomoniella corymbiae on Corymbia citriodora, Neophaeomoniella eucalyptigena on Eucalyptus pilularis, Pseudoplagiostoma corymbiicola on Corymbia citriodora, Teratosphaeria gracilis on Eucalyptus gracilis, Zasmidium corymbiae on Corymbia citriodora. Brazil, Calonectria hemileiae on pustules of Hemileia vastatrix formed on leaves of Coffea arabica, Calvatia caatinguensis on soil, Cercospora solani-betacei on Solanum betaceum, Clathrus natalensis on soil, Diaporthe poincianellae on Poincianella pyramidalis, Geastrum piquiriunense on soil, Geosmithia carolliae on wing of Carollia perspicillata, Henningsia resupinata on wood, Penicillium guaibinense from soil, Periconia caespitosa from leaf litter, Pseudocercospora styracina on Styrax sp., Simplicillium filiforme as endophyte from Citrullus lanatus, Thozetella pindobacuensis on leaf litter, Xenosonderhenia coussapoae on Coussapoa floccosa. ; Canary Islands (Spain), Orbilia amarilla on Euphorbia canariensis. Cape Verde Islands, Xylodon jacobaeus on Eucalyptus camaldulensis. Chile, Colletotrichum arboricola on Fuchsia magellanica. Costa Rica, Lasiosphaeria miniovina ontreebranch. Ecuador, Ganoderma chocoense ontreetrunk. France, Neofitzroyomyces nerii (incl. Neofitzroyomyces gen. nov.) on Nerium oleander. Ghana, Castanediella tereticornis on Eucalyptus tereticornis, Falcocladium africanum on Eucalyptus brassiana, Rachicladosporium corymbiae on Corymbia citriodora. Hungary, Entoloma silvae-frondosae in Carpinus betulus-Pinus sylvestris mixedforest. Iran, Pseudopyricularia persiana on Cyperus sp. Italy, Inocybe roseascens onsoilinmixedforest. Laos, Ophiocordyceps houaynhangensis on Coleoptera larva. Malaysia, Monilochaetes melastomae on Melastoma sp. Mexico, Absidia terrestris fromsoil. Netherlands, Acaulium pannemaniae, Conioscypha boutwelliae, Fusicolla septimanifiniscientiae, Gibellulopsis simonii, Lasionectria hilhorstii, Lectera nordwiniana, Leptodiscella rintelii, Parasarocladium debruynii and Sarocladium dejongiae (incl. Sarocladiaceae fam. nov.) fromsoil. New Zealand, Gnomoniopsis rosae on Rosa sp. and Neodevriesia metrosideri on Metrosideros sp. Puerto Rico, Neodevriesia coccolobae on Coccoloba uvifera, Neodevriesia tabebuiae and Alfaria tabebuiae on Tabebuia chrysantha. ; Russia, Amanita paludosa on bogged soil in mixed deciduous forest, Entoloma tiliae in forest of Tilia × europaea, Kwoniella endophytica on Pyrus communis. South Africa, Coniella diospyri on Diospyros mespiliformis, Neomelanconiella combreti (incl. Neomelanconiellaceae fam. nov. and Neomelanconiella gen. nov.)on Combretum sp., Polyphialoseptoria natalensis on unidentified plant host, Pseudorobillarda bolusanthi on Bolusanthus speciosus, Thelonectria pelargonii on Pelargonium sp. Spain, Vermiculariopsiella lauracearum and Anungitopsis lauri on Laurus novocanariensis, Geosmithia xerotolerans from a darkened wall of a house, Pseudopenidiella gallaica on leaf litter. Thailand, Corynespora thailandica on wood, Lareunionomyces loeiensis on leaf litter, Neocochlearomyces chromolaenae (incl. Neocochlearomyces gen. nov.) on Chromolaena odorata, Neomyrmecridium septatum (incl. Neomyrmecridium gen. nov .), Pararamichloridium caricicola on Carex sp., Xenodactylaria thailandica (incl. Xenodactylariaceae fam. nov. and Xenodactylaria gen. nov.), Neomyrmecridium asiaticum and Cymostachys thailandica fromunidentifiedvine. USA, Carolinigaster bonitoi (incl. Carolinigaster gen. nov.)fromsoil, Penicillium fortuitum from house dust, Phaeotheca shathenatiana (incl. Phaeothecaceae fam. nov.) from twig and cone litter, Pythium wohlseniorum from stream water, Superstratomyces tardicrescens from human eye, Talaromyces iowaense from officeair. Vietnam, Fistulinella olivaceoalba onsoil. Morphological and culture characteristics along with DNA barcodes are provided. ; Tatiana M. Bulyonkova and colleagues are grateful to Dr Rodham Tulloss for his patient guidance and help, and to Dr Torbjørn Borgen Lindhardt for his invaluable advice. Thays G.L. Oliveira, Maria T.C. Felipe, Jadson D.P. Bezerra and Oliane M. C. Magalhães acknowledge financial support and/or scholarships from the CAPES (Finance Code 001), CNPq and FACEPE. Aline O.B. da Cunha, Alexandre R. Machado, Eder Barbier, Enrico Bernard and Cristina M. Souza-Motta acknowledge financial support and/or scholarships from the CAPES (Finance Code 001), CNPq, FACEPE, CECAV and ICMBio from Brazil. Rejane M.F. da Silva and colleagues express their gratitude to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for a scholarship to Rejane M.F. da Silva and to the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a research fellowships and/or financial support to Gladstone A. da Silva, Cristina M. Souza-Motta, José L. Bezerra and Rafael J.V. de Oliveira (Processes 458622/2014-1 and 312186/2016-9). Olinto L. Pereira, Vanessa P. Abreu, Jackeline P. Andrade and colleagues would like to thank the CNPq, CAPES and FAPEMIG for financial support. The study of Olga V. Morozova was carried out within the framework of a research project of the Komarov Botanical Institute RAS 'Herbarium funds of the BIN RAS' (АААА-А18-118022090078-2) with the support of the molecular work by the Russian Foundation for the Basic Research (project no. 15-29-02622). Anna M. Glushakova and Aleksey V. Kachalkin were supported by the Russian Foundation for Basic Research (RFBR), project no. 16-04-00624a. Janet Jennifer Luangsa-ard and colleagues were supported by 'The Promotion Project on Science, Technology and Innovation Collaboration with ASEAN Member Countries under the Office of International Cooperation, MOSTThailand'. They would also like to thank Ms Duangkaew Chongkachornphong, Ms Papawee Nupason (International Cooperation Section, BIOTEC) and Ms Bakeo Souvannalath (Director of Biotechnology Division, Biotechnology and Ecology Institute, BEI) for their kind cooperation. Javier Fernández-López and colleagues are grateful to Marian Glenn for checking the text, and were supported by DGICT projects CGL2012-35559 and CGL2015-67459-P. ; Javier Fernández-López was also supported by Predoctoral Grants (BES- 2013-066429) from the Ministerio de Economía y Competitividad (Spain). Maria E. Ordoñez and colleagues acknowledge Pontificia Universidad Católica del Ecuador for financial support for project M13415. Taimy Cantillo is thankful to PEC-PG/CAPES for the PhD grant (proc. 12636134/2014) (Finance Code 001) and to the International Association for Plant Taxonomy (IAPT) for the Research Grant. Luis F.P. Gusmão is grateful to CNPq for Grant support (Proc. 303062/2014-2). Hugo Madrid was partially funded by Comisión Nacional de Investigación Científica y Tecnológica (CONICYT), Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT), Chile, project no. 11140562. Tor Erik Brandrud, Bálint Dima, Machiel E. Noordeloos and Egil Bendiksen thank the financial support of the Norwegian Taxonomy Initiative, with funding from the Norwegian Biodiversity Information Centre (NBIC) ; The Austrian Entoloma material (by Irmgard Krisai-Greilhuber) was sequenced within ABOL, subproject HRSFM University of Vienna, supported by the Austrian Federal Ministry of Education, Science and Research. Adriene M. Soares and colleagues would like to thank the Instituto Chico Mendes de Conservação da Biodiversidade (ICMBio) and the Instituto Brasileiro de Meio Ambiente (IBAMA) for support during field trips and R.L.M. Alvarenga for the figures. They also acknowledge CAPES for the Ph.D. scholarship of Adriene M. Soares, and CNPq (307601/2015-3), CAPES (CAPES-SIU 008/13), and FACEPE (APQ-0375-2.03/15) for financial support. Angus J. Carnegie acknowledges support from the Forestry Corporation of NSW, and David Sargeant for assistance with site photos. Adel Pordel and colleagues thank the University of Tehran for financial support. Luis Quijada acknowledges support from 'Fundación Ramón Areces'. Robert W. Barreto and colleagues thank the World Coffee Research/Texas Agrilife for financial support, as well as the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Sara Salcedo-Sarmiento was supported by the 'Programa de Estudante-Convênio de Pós-Graduação' (PEC-PG) from CAPES. The research of Cobus M. Visagie and Keith A. Seifert was supported by grants from the Alfred P. Sloan Foundation Program on the Microbiology of the Built Environment. Blaise A. Darvaux acknowledges Keith A. Seifert for help with identification, Nicholas Mauriello for validating the Latin name, Mauricia Lawrence and Meagan Tillotson for help with material preparation. We are grateful to Gavin Phillips, Seed Bank Officer, Australian Botanic Garden, Mt Annan for field assistance and identification of plant species collected in New South Wales, Australia. Collection of specimens from Mungo National Park was supported by the ABRS Bush Blitz program, a partnership between the Australian Government, BHP and Earthwatch Australia. The National Geographic Okavango Wilderness Project is acknowledged for assistance and funding to J. Roux for material collected in Angola. ; Peer reviewed

Austrian Federal Ministry of Education, Science and Research ; Austrian Science Fund ; Belgian Fonds de la Recherche Scientifique ; Fonds voor Wetenschappelijk Onderzoek ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; FAPERGS ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Bulgarian Ministry of Education and Science ; CERN ; Chinese Academy of Sciences ; Ministry of Science and Technology ; National Natural Science Foundation of China ; Colombian Funding Agency (COLCIENCIAS) ; Croatian Ministry of Science, Education and Sport ; Croatian Science Foundation ; Research Promotion Foundation, Cyprus ; Secretariat for Higher Education, Science, Technology and Innovation, Ecuador ; Ministry of Education and Research, Estonia ; Estonian Research Council, Estonia ; European Regional Development Fund, Estonia ; Academy of Finland ; Finnish Ministry of Education and Culture ; Helsinki Institute of Physics ; Institut National de Physique Nucleaire et de Physique des Particules / CNRS, France ; Commissariat a l'Energie Atomique et aux Energies Alternatives / CEA, France ; Bundesministerium fur Bildung und Forschung, Germany ; Deutsche Forschungsgemeinschaft, Germany ; Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany ; General Secretariat for Research and Technology, Greece ; National Research, Development and Innovation Fund, Hungary ; Department of Atomic Energy, India ; Department of Science and Technology, India ; Institute for Studies in Theoretical Physics and Mathematics, Iran ; Science Foundation, Ireland ; Istituto Nazionale di Fisica Nucleare, Italy ; Ministry of Science, ICT and Future Planning, Republic of Korea ; National Research Foundation (NRF), Republic of Korea ; Ministry of Education and Science of the Republic of Latvia ; Lithuanian Academy of Sciences ; Ministry of Education ; University of Malaya (Malaysia) ; Ministry of Science of Montenegro ; BUAP ; CINVESTAV ; CONACYT ; LNS ; SEP ; UASLP-FAI ; Ministry of Business, Innovation and Employment, New Zealand ; Pakistan Atomic Energy Commission ; Ministry of Science and Higher Education, Poland ; National Science Center, Poland ; Fundacao para a Ciencia e a Tecnologia, Portugal ; JINR, Dubna ; Ministry of Education and Science of the Russian Federation ; Federal Agency of Atomic Energy of the Russian Federation ; Russian Academy of Sciences ; Russian Foundation for Basic Research ; National Research Center Kurchatov Institute ; Ministry of Education, Science and Technological Development of Serbia ; Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Programa Consolider-Ingenio 2010, Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016, Plan de Ciencia, Tecnologia e Innovacion 2013-2017 del Principado de Asturias, S ; Fondo Europeo de Desarrollo Regional, Spain ; Ministry of Science, Technology and Research, Sri Lanka ; ETH Board ; PSI ; SNF ; UniZH ; Canton Zurich ; SER ; Ministry of Science and Technology, Taipei ; Thailand Center of Excellence in Physics ; Institute for the Promotion of Teaching Science and Technology of Thailand ; Special Task Force for Activating Research ; National Science and Technology Development Agency of Thailand ; Scientific and Technical Research Council of Turkey ; Turkish Atomic Energy Authority ; National Academy of Sciences of Ukraine, Ukraine ; State Fund for Fundamental Researches, Ukraine ; Science and Technology Facilities Council, U.K. ; US Department of Energy ; US National Science Foundation ; Marie-Curie program (European Union) ; European Research Council (European Union) ; Horizon 2020 (European Union) ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) ; F.R.S.-FNRS (Belgium) ; FWO (Belgium) ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Hungarian Academy of Sciences (Hungary) ; New National Excellence Program UNKP (Hungary) ; NKFIA (Hungary) ; Council of Scientific and Industrial Research, India ; HOMING PLUS program of the Foundation for Polish Science ; European Union, Regional Development Fund ; Mobility Plus program of the Ministry of Science and Higher Education ; National Science Center (Poland) ; National Priorities Research Program by Qatar National Research Fund ; Programa de Excelencia Maria de Maeztu ; Programa Severo Ochoa del Principado de Asturias ; Thalis program ; Aristeia program ; EU-ESF ; Greek NSRF ; Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) ; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) ; Welch Foundation ; Weston Havens Foundation (U.S.A.) ; Estonian Research Council, Estonia: IUT23-4 ; Estonian Research Council, Estonia: IUT23-6 ; Horizon 2020 (European Union): 675440 ; FWO (Belgium): 30820817 ; NKFIA (Hungary): 123842 ; NKFIA (Hungary): 123959 ; NKFIA (Hungary): 124845 ; NKFIA (Hungary): 124850 ; NKFIA (Hungary): 125105 ; National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 ; National Science Center (Poland): Opus 2014/13/B/ST2/02543 ; National Science Center (Poland): 2014/15/B/ST2/03998 ; National Science Center (Poland): 2015/19/B/ST2/02861 ; National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 ; Welch Foundation: C-1845 ; An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).

BMWFW (Austria) ; FWF (Austria) ; FNRS (Belgium) ; FWO (Belgium) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; MES (Bulgaria) ; CERN ; CAS (China) ; MoST (China) ; NSFC (China) ; COLCIENCIAS (Colombia) ; MSES (Croatia) ; CSF (Croatia) ; RPF (Cyprus) ; SENESCYT (Ecuador) ; MoER (Estonia) ; ERC IUT (Estonia) ; ERDF (Estonia) ; Academy of Finland (Finland) ; MEC (Finland) ; HIP (Finland) ; CEA (France) ; CNRS/IN2P3 (France) ; BMBF (Germany) ; DFG (Germany) ; HGF (Germany) ; GSRT (Greece) ; NKFIA (Hungary) ; DAE (India) ; DST (India) ; IPM (Iran) ; SFI (Ireland) ; INFN (Italy) ; MSIP (Republic of Korea) ; NRF (Republic of Korea) ; LAS (Lithuania) ; MOE (Malaysia) ; UM (Malaysia) ; BUAP (Mexico) ; CINVESTAV (Mexico) ; CONACYT (Mexico) ; LNS (Mexico) ; SEP (Mexico) ; UASLP-FAI (Mexico) ; MBIE (New Zealand) ; PAEC (Pakistan) ; MSHE (Poland) ; NSC (Poland) ; FCT (Portugal) ; JINR (Dubna) ; MON (Russia) ; RosAtom (Russia) ; RAS (Russia) ; RFBR (Russia) ; MESTD (Serbia) ; SEIDI (Spain) ; CPAN (Spain) ; PCTI (Spain) ; FEDER (Spain) ; Swiss Funding Agencies (Switzerland) ; MST (Taipei) ; ThEPCenter (Thailand) ; IPST (Thailand) ; STAR (Thailand) ; NSTDA (Thailand) ; TUBITAK (Turkey) ; TAEK (Turkey) ; NASU (Ukraine) ; SFFR (Ukraine) ; STFC (United Kingdom) ; DOE (U.S.A.) ; NSF (U.S.A.) ; Marie-Curie programme (European Union) ; European Research Council (European Union) ; Horizon 2020 Grant (European Union) ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) ; F.R.S.-FNRS (Belgium) under the Excellence of Science - EOS - be.h project ; FWO (Belgium) under the Excellence of Science - EOS - be.h project ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Lendulet (Momentum) Programme of the Hungarian Academy of Sciences ; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences ; New National Excellence Program UNKP ; NKFIA research grants (Hungary) ; Council of Science and Industrial Research, India ; HOMING PLUS programme of the Foundation for Polish Science ; European Union, Regional Development Fund ; Mobility Plus programme of the Ministry of Science and Higher Education ; National Science Center (Poland) ; National Priorities Research Program by Qatar National Research Fund ; Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu ; Programa Severo Ochoa del Principado de Asturias ; Thalis programme - EU-ESF ; Aristeia programme - EU-ESF ; Greek NSRF ; Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) ; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) ; Welch Foundation ; Weston Havens Foundation (U.S.A.) ; European Research Council (European Union): 675440 ; Horizon 2020 Grant (European Union): 675440 ; F.R.S.-FNRS (Belgium) under the Excellence of Science - EOS - be.h project: 30820817 ; FWO (Belgium) under the Excellence of Science - EOS - be.h project: 30820817 ; NKFIA research grants (Hungary): 123842 ; NKFIA research grants (Hungary): 123959 ; NKFIA research grants (Hungary): 124845 ; NKFIA research grants (Hungary): 124850 ; NKFIA research grants (Hungary): 125105 ; National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 ; National Science Center (Poland): Opus 2014/13/B/ST2/02543 ; National Science Center (Poland): 2014/15/B/ST2/03998 ; National Science Center (Poland): 2015/19/B/ST2/02861 ; National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 ; Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu: MDM-2015-0509 ; Welch Foundation: C-1845 ; A search for the pair production of heavy fermionic partners of the top quark with charge 5/3 (X-5/3) is performed in proton-proton collisions at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The data sample analyzed corresponds to an integrated luminosity of 35.9 fb(-1). The X-5/3 quark is assumed always to decay into a top quark and a W boson. Both the right-handed and left-handed X-5/3 couplings to the W boson are considered. Final states with either a pair of same-sign leptons or a single lepton are studied. No significant excess of events is observed above the expected standard model background. Lower limits at 95% confidence level on the X-5/3 quark mass are set at 1.33 and 1.30 TeV respectively for the case of right-handed and left-handed couplings to W bosons in a combination of the same-sign dilepton and single-lepton final states.

Austrian Federal Ministry of Science, Research and Economy ; Austrian Science Fund ; Belgian Fonds de la Recherche Scientifique ; Fonds voor Wetenschappelijk Onderzoek ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Brazilian Funding Agency (FAPERGS) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Bulgarian Ministry of Education and Science ; CERN ; Chinese Academy of Sciences, Ministry of Science and Technology ; National Natural Science Foundation of China ; Colombian Funding Agency (COLCIENCIAS ; Croatian Ministry of Science, Education and Sport ; Croatian Science Foundation ; Research Promotion Foundation, Cyprus ; Secretariat for Higher Education, Science, Technology and Innovation, Ecuador ; Ministry of Education and Research, Estonia ; Estonian Research Council, Estonia ; European Regional Development Fund, Estonia ; Academy of Finland ; Finnish Ministry of Education and Culture ; Helsinki Institute of Physics ; Institut National de Physique Nucleaire et de Physique des Particules/CNRS, France ; Commissariat a l'Energie Atomique et aux Energies Alternatives/CEA, France ; Bundesministerium fur Bildung und Forschung, Germany ; Deutsche Forschungsgemeinschaft, Germany ; Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany ; General Secretariat for Research and Technology, Greece ; National Research, Development and Innovation Fund, Hungary ; Department of Atomic Energy, India ; Department of Science and Technology, India ; Institute for Studies in Theoretical Physics and Mathematics, Iran ; Science Foundation, Ireland ; Istituto Nazionale di Fisica Nucleare, Italy ; Ministry of Science, ICT and Future Planning, Republic of Korea ; National Research Foundation (NRF), Republic of Korea ; Lithuanian Academy of Sciences ; Ministry of Education (Malaysia) ; University of Malaya (Malaysia) ; Ministry of Science of Montenegro ; Mexican Funding Agency (BUAP) ; Mexican Funding Agency (CINVESTAV) ; Mexican Funding Agency (CONACYT) ; Mexican Funding Agency (LNS) ; Mexican Funding Agency (SEP) ; Mexican Funding Agency (UASLP-FAI) ; Ministry of Business, Innovation and Employment, New Zealand ; Pakistan Atomic Energy Commission ; Ministry of Science and Higher Education, Poland ; National Science Center, Poland ; Fundacao para a Ciencia e a Tecnologia, Portugal ; JINR, Dubna ; Ministry of Education and Science of the Russian Federation ; Federal Agency of Atomic Energy of the Russian Federation ; Russian Academy of Sciences ; Russian Foundation for Basic Research ; National Research Center Kurchatov Institute ; Ministry of Education, Science and Technological Development of Serbia ; Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Programa Consolider-Ingenio 2010, Spain ; Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016, Spain ; Plan de Ciencia, Tecnologia e Innovacion 2013-2017 del Principado de Asturias, Spain ; Fondo Europeo de Desarrollo Regional, Spain ; Ministry of Science, Technology and Research, Sri Lanka ; Swiss Funding Agency (ETH Board) ; Swiss Funding Agency (ETH Zurich) ; Swiss Funding Agency (PSI) ; Swiss Funding Agency (SNF) ; Swiss Funding Agency (UniZH) ; Swiss Funding Agency (Canton Zurich) ; Swiss Funding Agency (SER) ; Ministry of Science and Technology, Taipei ; Thailand Center of Excellence in Physics ; Institute for the Promotion of Teaching Science and Technology of Thailand ; Special Task Force for Activating Research ; National Science and Technology Development Agency of Thailand ; Scientific and Technical Research Council of Turkey ; Turkish Atomic Energy Authority ; National Academy of Sciences of Ukraine, Ukraine ; State Fund for Fundamental Researches, Ukraine ; Science and Technology Facilities Council, U.K. ; U.S. Department of Energy ; U.S. National Science Foundation ; Marie-Curie program (European Union) ; European Research Council and Horizon 2020 Grant (European Union) ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; F.R.S.-FNRS (Belgium) under the Excellence of Science - EOS - be.h project ; FWO (Belgium) under the Excellence of Science - EOS - be.h project ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Lendulet (Momentum) Program (Hungary) ; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (Hungary) ; New National Excellence Program UNKP (Hungary) ; NKFIA (Hungary) ; Council of Scientific and Industrial Research, India ; HOMING PLUS program of the Foundation for Polish Science ; European Union, Regional Development Fund (Poland) ; Mobility Plus program of the Ministry of Science and Higher Education (Poland) ; National Science Center (Poland) ; National Priorities Research Program by Qatar National Research Fund ; Programa de Excelencia Maria de Maeztu ; Programa Severo Ochoa del Principado de Asturias ; Thalis program - EU-ESF ; Aristeia program - EU-ESF ; Greek NSRF ; Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) ; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) ; Welch Foundation ; Weston Havens Foundation (U.S.A.) ; Estonian Research Council, Estonia: IUT23-4 ; Estonian Research Council, Estonia: IUT23-6 ; European Research Council and Horizon 2020 Grant (European Union): 675440 ; F.R.S.-FNRS (Belgium) under the Excellence of Science - EOS - be.h project: 30820817 ; FWO (Belgium) under the Excellence of Science - EOS - be.h project: 30820817 ; NKFIA (Hungary): 123842 ; NKFIA (Hungary): 123959 ; NKFIA (Hungary): 124845 ; NKFIA (Hungary): 124850 ; NKFIA (Hungary): 125105 ; European Union, Regional Development Fund (Poland): Harmonia 2014/14/M/ST2/00428 ; European Union, Regional Development Fund (Poland): Opus 2014/13/B/ST2/02543 ; European Union, Regional Development Fund (Poland): 2014/15/B/ST2/03998 ; European Union, Regional Development Fund (Poland): 2015/19/B/ST2/02861 ; European Union, Regional Development Fund (Poland): Sonata-bis 2012/07/E/ST2/01406 ; Mobility Plus program of the Ministry of Science and Higher Education (Poland): Harmonia 2014/14/M/ST2/00428 ; Mobility Plus program of the Ministry of Science and Higher Education (Poland): Opus 2014/13/B/ST2/02543 ; Mobility Plus program of the Ministry of Science and Higher Education (Poland): 2014/15/B/ST2/03998 ; Mobility Plus program of the Ministry of Science and Higher Education (Poland): 2015/19/B/ST2/02861 ; Mobility Plus program of the Ministry of Science and Higher Education (Poland): Sonata-bis 2012/07/E/ST2/01406 ; National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 ; National Science Center (Poland): Opus 2014/13/B/ST2/02543 ; National Science Center (Poland): 2014/15/B/ST2/03998 ; National Science Center (Poland): 2015/19/B/ST2/02861 ; National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 ; Welch Foundation: C-1845 ; A search is performed for a heavy Majorana neutrino (N), produced in leptonic decay of a W boson propagator and decaying into a W boson and a lepton, with the CMS detector at the LHC. The signature used in this search consists of two same-sign leptons, in any flavor combination of electrons and muons, and at least one jet. The data were collected during 2016 in proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). The results are found to be consistent with the expected standard model background. Upper limits are set in the mass range between 20 and 1600 GeV in the context of a Type-I seesaw mechanism, on |V-eN|(2), |V-N|(2), and |VeNV *|(2)/(|V-eN|(2)+|V-N|(2)), where V-N is the matrix element describing the mixing of N with the standard model neutrino of flavor = e, . For N masses between 20 and 1600 GeV, the upper limits on |V-N|(2) range between 2.3 x 10(-5) and unity. These are the most restrictive direct limits for heavy Majorana neutrino masses above 430 GeV.