Suchergebnisse

For the past decade, docetaxel has remained the global standard of care for frontline treatment of metastatic castration-resistant prostate cancer (mCRPC). Until recently, there were limited options for patients with mCRPC following docetaxel failure or resistance, but now the approved treatment choices for these patients have expanded to include abiraterone acetate, cabazitaxel and enzalutamide. Additionally, the radioactive therapeutic agent radium-223 dichloride has been recently approved in patients with CRPC with bone metastases. Although each of these agents has been shown to convey significant survival benefit as a monotherapy, preclinical findings suggest that combining such innovative strategies with traditional treatments may achieve additive or synergistic effects, further augmenting patient benefit. This review will discuss the transformation of the post-docetaxel space in mCRPC, highlighting the spectrum of newly approved agents in this setting in the USA and the European Union, as well as summarizing treatments with non-chemotherapeutic mechanisms of action that have demonstrated promising results in recent phase 3 trials. Lastly, this review will address the potential of combinatorial regimens in mCRPC, including the pairing of novel immunotherapeutic approaches with chemotherapy, radiotherapy or androgen ablation.

Polymeric syntactic foams refer to a class of cellular material created using preformed hollow spheres bound together with a polymeric matrix. These cellular materials possess exceptional ability to respond against high impact dynamic loads. This paper is an attempt to fabricate polymeric syntactic foams of epoxy containing hollow glass microballoon at varying loading (40 % - 60 %) and explore their potential towards blast mitigation. The tensile, compressive and flexural strength were found to be inversely proportional to the microballoon loading in the quasi-static regime. The strain rate sensitivity of the foams was confirmed by performing high strain rate studies using split hopkinson pressure bar. The flow stress of these foams was found to increase with increasing strain rates. The syntactic foams were subjected to controlled transient blast loadings using a shock tube. The samples remained intact and no strain was observed on the strain gauge, even under a blast load of ~ 90 psi, which clearly highlight their potential as core materials for blast mitigating applications.

The Geospatial Delhi Limited (GSDL), a Govt. of NCT of Delhi Company formed in order to provide the geospatial information of National Capital Territory of Delhi (NCTD) to the Government of National Capital Territory of Delhi (GNCTD) and its organs such as DDA, MCD, DJB, State Election Department, DMRC etc., for the benefit of all citizens of Government of National Capital Territory of Delhi (GNCTD). This paper describes the development of Geospatial Map based Portal (GMP) for New Delhi Municipal Council (NDMC) of NCT of Delhi. The GMP has been developed as a map based spatial decision support system (SDSS) for planning and development of NDMC area to the NDMC department and It's heaving the inbuilt information searching tools (identifying of location, nearest utilities locations, distance measurement etc.) for the citizens of NCTD. The GMP is based on Client-Server architecture model. It has been developed using Arc GIS Server 10.0 with .NET (pronounced dot net) technology. The GMP is scalable to enterprise SDSS with enterprise Geo Database & Virtual Private Network (VPN) connectivity. Spatial data to GMP includes Circle, Division, Sub-division boundaries of department pertaining to New Delhi Municipal Council, Parcels of residential, commercial, and government buildings, basic amenities (Police Stations, Hospitals, Schools, Banks, ATMs and Fire Stations etc.), Over-ground and Underground utility network lines, Roads, Railway features. GMP could help achieve not only the desired transparency and easiness in planning process but also facilitates through efficient & effective tools for development and management of MCD area. It enables a faster response to the changing ground realities in the development planning, owing to its in-built scientific approach and open-ended design.

The Geospatial Delhi Limited (GSDL), a Govt. of NCT of Delhi Company formed in order to provide the geospatial information of National Capital Territory of Delhi (NCTD) to the Government of National Capital Territory of Delhi (GNCTD) and its organs such as DDA, MCD, DJB, State Election Department, DMRC etc., for the benefit of all citizens of Government of National Capital Territory of Delhi (GNCTD). This paper describes the development of Geospatial Map based Portal for Delimitation of MCD Wards (GMPDW) and election of 3 Municipal Corporations of NCT of Delhi. The portal has been developed as a map based spatial decision support system (SDSS) for delimitation of MCD Wards and draw of peripheral wards boundaries to planning and management of MCD Election process of State Election Commission, and as an MCD election related information searching tools (Polling Station, MCD Wards and Assembly constituency etc.,) for the citizens of NCTD. The GMPDW is based on Client-Server architecture model. It has been developed using Arc GIS Server 10.0 with .NET (pronounced dot net) technology. The GMPDW is scalable to enterprise SDSS with enterprise Geo Database & Virtual Private Network (VPN) connectivity. Spatial data to GMPDW includes Enumeration Block (EB) and Enumeration Blocks Group (EBG) boundaries of Citizens of Delhi, Assembly Constituency, Parliamentary Constituency, Election District, Landmark locations of Polling Stations & basic amenities (Police Stations, Hospitals, Schools and Fire Stations etc.). GMPDW could help achieve not only the desired transparency and easiness in planning process but also facilitates through efficient & effective tools for management of MCD election. It enables a faster response to the changing ground realities in the development planning, owing to its in-built scientific approach and open-ended design.

The Geospatial Delhi Limited (GSDL), a Govt. of NCT of Delhi Company formed in order to provide the geospatial information of National Capital Territory of Delhi (NCTD) to the Government of National Capital Territory of Delhi (GNCTD) and its organs such as DDA, MCD, DJB, State Election Department, DMRC etc., for the benefit of all citizens of Government of National Capital Territory of Delhi (GNCTD). This paper describes the development of Geospatial Map based Portal (GMP) for New Delhi Municipal Council (NDMC) of NCT of Delhi. The GMP has been developed as a map based spatial decision support system (SDSS) for planning and development of NDMC area to the NDMC department and It's heaving the inbuilt information searching tools (identifying of location, nearest utilities locations, distance measurement etc.) for the citizens of NCTD. The GMP is based on Client-Server architecture model. It has been developed using Arc GIS Server 10.0 with .NET (pronounced dot net) technology. The GMP is scalable to enterprise SDSS with enterprise Geo Database & Virtual Private Network (VPN) connectivity. Spatial data to GMP includes Circle, Division, Sub-division boundaries of department pertaining to New Delhi Municipal Council, Parcels of residential, commercial, and government buildings, basic amenities (Police Stations, Hospitals, Schools, Banks, ATMs and Fire Stations etc.), Over-ground and Underground utility network lines, Roads, Railway features. GMP could help achieve not only the desired transparency and easiness in planning process but also facilitates through efficient & effective tools for development and management of MCD area. It enables a faster response to the changing ground realities in the development planning, owing to its in-built scientific approach and open-ended design.

The Geospatial Delhi Limited (GSDL), a Govt. of NCT of Delhi Company formed in order to provide the geospatial information of National Capital Territory of Delhi (NCTD) to the Government of National Capital Territory of Delhi (GNCTD) and its organs such as DDA, MCD, DJB, State Election Department, DMRC etc., for the benefit of all citizens of Government of National Capital Territory of Delhi (GNCTD). This paper describes the development of Geospatial Map based Portal for Delimitation of MCD Wards (GMPDW) and election of 3 Municipal Corporations of NCT of Delhi. The portal has been developed as a map based spatial decision support system (SDSS) for delimitation of MCD Wards and draw of peripheral wards boundaries to planning and management of MCD Election process of State Election Commission, and as an MCD election related information searching tools (Polling Station, MCD Wards and Assembly constituency etc.,) for the citizens of NCTD. The GMPDW is based on Client-Server architecture model. It has been developed using Arc GIS Server 10.0 with .NET (pronounced dot net) technology. The GMPDW is scalable to enterprise SDSS with enterprise Geo Database & Virtual Private Network (VPN) connectivity. Spatial data to GMPDW includes Enumeration Block (EB) and Enumeration Blocks Group (EBG) boundaries of Citizens of Delhi, Assembly Constituency, Parliamentary Constituency, Election District, Landmark locations of Polling Stations & basic amenities (Police Stations, Hospitals, Schools and Fire Stations etc.). GMPDW could help achieve not only the desired transparency and easiness in planning process but also facilitates through efficient & effective tools for management of MCD election. It enables a faster response to the changing ground realities in the development planning, owing to its in-built scientific approach and open-ended design.

The protective structures required for performing critical operations are vulnerable to the blast and shock loads of advanced weapons. A blast valve is an important component of such structures for ventilation during normal conditions and for protection from blast/ shock during explosion. In this paper, various aspects of blast valve design and related studies are briefly reviewed. The concept and effects of blast wave, blast impact, numerical modelling and deformation of circular plate (one of the critical components of blast valve) have been discussed. The merits and demerits of sensing mechanisms viz. remote and direct sensing are discussed. The leakage of blast pressure during finite closing period of the valve (one of the critical problems) and the shock tube as a major experimental facility for testing of blast valves are briefly discussed.

The central purpose of this report is to examine the principal factors that have contributed to the saving and investment performance of India in the last 35 years and the role financial development has played. The first chapter surveys India's development strategies during that period and the second chapter offers a broad picture of growth and structural change in the Indian economy. Chapter 3 examines the saving behaviour in India and its determinants, to indicate the extent to which changes encompassed by the term "financial development" accounted for the impressive incrcease in domestic savings. (DÜI-Sbt)

In water‐cooled nuclear power reactors, significant quantities of hydrogen could be produced following a postulated loss‐of‐coolant accident (LOCA) along with nonavailability of emergency core cooling system (ECCS). Passive autocatalytic recombiners (PAR) are implemented in the containment of water‐cooled power reactors to mitigate the risk of hydrogen combustion. In the presence of hydrogen with available oxygen, a catalytic reaction occurs spontaneously at the catalyst surfaces below conventional ignition concentration limits and temperature and even in presence of steam. Heat of reaction produces natural convection flow through the enclosure and promotes mixing in the containment. For the assessment of the PAR performance in terms of maximum temperature of catalyst surface and outlet hydrogen concentration an in‐house 3D CFD model has been developed. The code has been used to study the mechanism of catalytic recombination and has been tested for two literature‐quoted experiments.